公开(公告)号：US08476255B2

公开(公告)日：2013-07-02

申请号：US12734026

申请日：2008-10-08

申请人： Sridharan Rajagopal ,  Virendra Kachhadia ,  Thanasekaran Ponpandian ,  Abdul Raheem Keeri ,  Umamaheswari Mani ,  Suresh Rathinasamy ,  Praveen Rajendran ,  Kamaraj Mani ,  Balaji Ramachandran ,  Punthalir Narayanaswamy ,  Sriram Rajagopal

发明人： Sridharan Rajagopal ,  Virendra Kachhadia ,  Thanasekaran Ponpandian ,  Abdul Raheem Keeri ,  Umamaheswari Mani ,  Suresh Rathinasamy ,  Praveen Rajendran ,  Kamaraj Mani ,  Balaji Ramachandran ,  Punthalir Narayanaswamy ,  Sriram Rajagopal

IPC分类号： A01N43/00 ,  A61K31/33 ,  A61K31/16 ,  A01N37/18 ,  C07D215/38

CPC分类号： C07C237/42 ,  C07C237/22 ,  C07C259/06 ,  C07C259/10 ,  C07C271/22 ,  C07C275/50 ,  C07C2601/02 ,  C07D213/56 ,  C07D215/14 ,  C07D317/60 ,  C07D333/24 ,  C07D333/44

摘要： Provided herein are novel, stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, metabolites, prodrugs, solvates, pharmaceutically acceptable salts and compositions thereof. These compounds can inhibit HDACs and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, etc.

摘要翻译： 本文提供了新颖的通式（I）的二苯乙烯类化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，代谢物，前药，溶剂合物，药学上可接受的盐和组合物。 这些化合物可以抑制HDAC，并且可用作涉及细胞生长的疾病如恶性肿瘤，自身免疫性疾病，皮肤病，感染，炎症等的治疗或改善剂。

公开(公告)号：US20100222379A1

公开(公告)日：2010-09-02

申请号：US12734026

申请日：2008-10-08

申请人： Sridharan Rajagopal ,  Virendra Kachhadia ,  Thanasekaran Ponpandian ,  Abdul Raheem Keeri ,  Umamaheswari Mani ,  Suresh Rathinasamy ,  Praveen Rajendran ,  Kamaraj Mani ,  Balaji Ramachandran ,  Punthalir Narayanaswamy ,  Sriram Rajagopal

发明人： Sridharan Rajagopal ,  Virendra Kachhadia ,  Thanasekaran Ponpandian ,  Abdul Raheem Keeri ,  Umamaheswari Mani ,  Suresh Rathinasamy ,  Praveen Rajendran ,  Kamaraj Mani ,  Balaji Ramachandran ,  Punthalir Narayanaswamy ,  Sriram Rajagopal

IPC分类号： A61K31/167 ,  C07C237/40 ,  C07D215/38 ,  A61K31/47 ,  A61P35/00

CPC分类号： C07C237/42 ,  C07C237/22 ,  C07C259/06 ,  C07C259/10 ,  C07C271/22 ,  C07C275/50 ,  C07C2601/02 ,  C07D213/56 ,  C07D215/14 ,  C07D317/60 ,  C07D333/24 ,  C07D333/44

摘要： Provided herein are novel, stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, metabolites, prodrugs, solvates, pharmaceutically acceptable salts and compositions thereof. These compounds can inhibit HDACs and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as WO 2009/047615 A2 malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, etc.

摘要翻译： 本文提供了新颖的通式（I）的二苯乙烯类化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，代谢物，前药，溶剂化物，药学上可接受的盐和组合物。 这些化合物可以抑制HDAC，并且可用作涉及细胞生长的疾病的治疗或改善剂，例如WO 2009/047615A2恶性肿瘤，自身免疫性疾病，皮肤病，感染，炎症等。