公开(公告)号：US08476255B2

公开(公告)日：2013-07-02

申请号：US12734026

申请日：2008-10-08

申请人： Sridharan Rajagopal ,  Virendra Kachhadia ,  Thanasekaran Ponpandian ,  Abdul Raheem Keeri ,  Umamaheswari Mani ,  Suresh Rathinasamy ,  Praveen Rajendran ,  Kamaraj Mani ,  Balaji Ramachandran ,  Punthalir Narayanaswamy ,  Sriram Rajagopal

发明人： Sridharan Rajagopal ,  Virendra Kachhadia ,  Thanasekaran Ponpandian ,  Abdul Raheem Keeri ,  Umamaheswari Mani ,  Suresh Rathinasamy ,  Praveen Rajendran ,  Kamaraj Mani ,  Balaji Ramachandran ,  Punthalir Narayanaswamy ,  Sriram Rajagopal

IPC分类号： A01N43/00 ,  A61K31/33 ,  A61K31/16 ,  A01N37/18 ,  C07D215/38

CPC分类号： C07C237/42 ,  C07C237/22 ,  C07C259/06 ,  C07C259/10 ,  C07C271/22 ,  C07C275/50 ,  C07C2601/02 ,  C07D213/56 ,  C07D215/14 ,  C07D317/60 ,  C07D333/24 ,  C07D333/44

摘要： Provided herein are novel, stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, metabolites, prodrugs, solvates, pharmaceutically acceptable salts and compositions thereof. These compounds can inhibit HDACs and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, etc.

摘要翻译： 本文提供了新颖的通式（I）的二苯乙烯类化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，代谢物，前药，溶剂合物，药学上可接受的盐和组合物。 这些化合物可以抑制HDAC，并且可用作涉及细胞生长的疾病如恶性肿瘤，自身免疫性疾病，皮肤病，感染，炎症等的治疗或改善剂。

公开(公告)号：US20100222379A1

公开(公告)日：2010-09-02

申请号：US12734026

申请日：2008-10-08

申请人： Sridharan Rajagopal ,  Virendra Kachhadia ,  Thanasekaran Ponpandian ,  Abdul Raheem Keeri ,  Umamaheswari Mani ,  Suresh Rathinasamy ,  Praveen Rajendran ,  Kamaraj Mani ,  Balaji Ramachandran ,  Punthalir Narayanaswamy ,  Sriram Rajagopal

发明人： Sridharan Rajagopal ,  Virendra Kachhadia ,  Thanasekaran Ponpandian ,  Abdul Raheem Keeri ,  Umamaheswari Mani ,  Suresh Rathinasamy ,  Praveen Rajendran ,  Kamaraj Mani ,  Balaji Ramachandran ,  Punthalir Narayanaswamy ,  Sriram Rajagopal

IPC分类号： A61K31/167 ,  C07C237/40 ,  C07D215/38 ,  A61K31/47 ,  A61P35/00

CPC分类号： C07C237/42 ,  C07C237/22 ,  C07C259/06 ,  C07C259/10 ,  C07C271/22 ,  C07C275/50 ,  C07C2601/02 ,  C07D213/56 ,  C07D215/14 ,  C07D317/60 ,  C07D333/24 ,  C07D333/44

摘要： Provided herein are novel, stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, metabolites, prodrugs, solvates, pharmaceutically acceptable salts and compositions thereof. These compounds can inhibit HDACs and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as WO 2009/047615 A2 malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, etc.

摘要翻译： 本文提供了新颖的通式（I）的二苯乙烯类化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，代谢物，前药，溶剂化物，药学上可接受的盐和组合物。 这些化合物可以抑制HDAC，并且可用作涉及细胞生长的疾病的治疗或改善剂，例如WO 2009/047615A2恶性肿瘤，自身免疫性疾病，皮肤病，感染，炎症等。

公开(公告)号：US08450525B2

公开(公告)日：2013-05-28

申请号：US12734030

申请日：2008-10-21

申请人： Sridharan Rajagopal ,  Virendra Kachhadia ,  Thanasekaran Ponpandian ,  Abdul Raheem Keeri ,  Karnambaram Anandhan ,  Sriram Rajagopal ,  Rajendran Praveen ,  Prabhu Daivasigamani

发明人： Sridharan Rajagopal ,  Virendra Kachhadia ,  Thanasekaran Ponpandian ,  Abdul Raheem Keeri ,  Karnambaram Anandhan ,  Sriram Rajagopal ,  Rajendran Praveen ,  Prabhu Daivasigamani

IPC分类号： C07C233/65 ,  A61K31/16

CPC分类号： C07C259/06 ,  C07C233/44 ,  C07C237/38 ,  C07C237/40 ,  C07C259/10 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/18 ,  C07D209/18 ,  C07D213/56 ,  C07D295/185 ,  C07D317/60 ,  C07D333/24

摘要： Novel compounds of the general formula (I), having histone deacetylase (HDAC) inhibiting enzymatic activity, their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I).

摘要翻译： 具有抑制酶活性的组蛋白脱乙酰酶（HDAC），其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，中间体，药学上可接受的盐，药物组合物，代谢物和前药的通式（I）的新型化合物。 本发明更具体地提供了通式（I）的新型化合物。 还包括在哺乳动物中治疗癌症，牛皮癣，增殖性病症和由HDAC介导的病症的方法，包括施用有效量的新的式（I）化合物。

公开(公告)号：US20100291003A1

公开(公告)日：2010-11-18

申请号：US12734030

申请日：2008-10-21

申请人： Sridharan Rajagopal ,  Virendra Kachhadia ,  Thanasekaran Ponpandian ,  Abdul Raheem Keeri ,  Karnambaram Anandhan ,  Sriram Rajagopal ,  Rajendran Praveen ,  Prabhu Daivasigamani

发明人： Sridharan Rajagopal ,  Virendra Kachhadia ,  Thanasekaran Ponpandian ,  Abdul Raheem Keeri ,  Karnambaram Anandhan ,  Sriram Rajagopal ,  Rajendran Praveen ,  Prabhu Daivasigamani

IPC分类号： A61K9/12 ,  C12N5/02 ,  A61K31/54 ,  A61K31/535 ,  A61K31/36 ,  A61K31/16 ,  C07D279/12 ,  C07D295/18 ,  C07D317/44 ,  C07C233/00 ,  A61P35/04

CPC分类号： C07C259/06 ,  C07C233/44 ,  C07C237/38 ,  C07C237/40 ,  C07C259/10 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/18 ,  C07D209/18 ,  C07D213/56 ,  C07D295/185 ,  C07D317/60 ,  C07D333/24

摘要： Novel compounds of the general formula (I), having histone deacetylase (HDAC) inhibiting enzymatic activity, their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I).

摘要翻译： 具有抑制酶活性的组蛋白脱乙酰酶（HDAC），其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，中间体，药学上可接受的盐，药物组合物，代谢物和前药的通式（I）的新型化合物。 本发明更具体地提供了通式（I）的新型化合物。 还包括在哺乳动物中治疗癌症，牛皮癣，增殖性病症和由HDAC介导的病症的方法，包括施用有效量的新的式（I）化合物。

公开(公告)号：US20110212943A1

公开(公告)日：2011-09-01

申请号：US13123983

申请日：2009-10-14

申请人： Gopalan Balasubramanian ,  Ponpandian Thanasekaran ,  Sridharan Rajagopal ,  Bharathimohan Kuppusamy ,  Virendra Kachhadia ,  Vignesh Radhakrishnan ,  Sivasudar Velaiah ,  Shridhar Narayanan ,  Mandar Bhonde ,  Praveen Rajendran ,  Sriram Rajagopal

发明人： Gopalan Balasubramanian ,  Ponpandian Thanasekaran ,  Sridharan Rajagopal ,  Bharathimohan Kuppusamy ,  Virendra Kachhadia ,  Vignesh Radhakrishnan ,  Sivasudar Velaiah ,  Shridhar Narayanan ,  Mandar Bhonde ,  Praveen Rajendran ,  Sriram Rajagopal

IPC分类号： A61K31/165 ,  C07C237/20 ,  C07D223/14 ,  C07C237/22 ,  C07D207/337 ,  C07D307/54 ,  C07C231/02 ,  C07C229/46 ,  A61K31/55 ,  A61K31/40 ,  A61K31/341 ,  C12N9/99 ,  A61P29/00 ,  A61P19/02 ,  A61P31/00 ,  A61P1/00 ,  A61P25/28 ,  A61P35/00 ,  A61P35/04

CPC分类号： C07C259/06 ,  C07C237/20 ,  C07C237/42 ,  C07C271/22 ,  C07C2603/74 ,  C07D207/337 ,  C07D471/18

摘要： Provided herein are novel bridged cyclic derivatives of the general formula (I), their analogs, tautomeric forms, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds can inhibit HDACs and are useful as therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, neurode-generative disorders etc.

摘要翻译： 本文提供了通式（I）的新型桥连环衍生物，其类似物，互变异构形式，立体异构体，多晶型物，溶剂化物，中间体，药学上可接受的盐，药物组合物，代谢物和前药。 这些化合物可以抑制HDAC，并且可用作涉及细胞生长的疾病如恶性肿瘤，自身免疫疾病，皮肤疾病，感染，炎症，神经发生障碍等的治疗或改善剂。

公开(公告)号：US20100298402A1

公开(公告)日：2010-11-25

申请号：US12734484

申请日：2008-11-04

申请人： Sridharan Rajagopal ,  Thangapazham Selvakumar ,  Kuppusamy Bharathimohan ,  Virendra Kachhadia ,  Sriram Rajagopal ,  Rajendran Praveen ,  Ramachandran Balaji

发明人： Sridharan Rajagopal ,  Thangapazham Selvakumar ,  Kuppusamy Bharathimohan ,  Virendra Kachhadia ,  Sriram Rajagopal ,  Rajendran Praveen ,  Ramachandran Balaji

IPC分类号： A61K31/381 ,  C07C229/34 ,  C07D333/22 ,  C07C237/20 ,  A61K31/24 ,  A61K31/165 ,  A61P35/00 ,  A61P29/00 ,  A61P17/06 ,  A61P19/08 ,  A61P31/00 ,  A61P1/18 ,  A61P19/10 ,  A61P35/02 ,  A61P1/16 ,  A61P7/06 ,  A61P3/10 ,  A61P13/12 ,  A61P1/00 ,  A61P25/00

CPC分类号： C07C217/32 ,  C07C217/48 ,  C07C235/34 ,  C07D333/24

摘要： Described are novel compounds of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These novel compounds can inhibit pSTAT3/IL-6 and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, etc.

摘要翻译： 描述了式（I）的新化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，中间体，药学上可接受的盐，药物组合物，代谢物和前药。 这些新型化合物可以抑制pSTAT3 / IL-6，并且可用作涉及细胞生长的疾病如恶性肿瘤，自身免疫性疾病，皮肤病，感染，炎症等的治疗或改善剂。

公开(公告)号：US07863446B2

公开(公告)日：2011-01-04

申请号：US12068668

申请日：2008-02-08

申请人： Akella Satya Surya Visweswara Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Sappanimuthu Thirunavukkarasu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narsimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Gaddam Om Reddy ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam ,  Maruthikumar Narayanam ,  Sathyanarayana Gadde ,  Uma Ramachandran

发明人： Akella Satya Surya Visweswara Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Sappanimuthu Thirunavukkarasu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narsimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Gaddam Om Reddy ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam ,  Maruthikumar Narayanam ,  Sathyanarayana Gadde ,  Uma Ramachandran

IPC分类号： C07D239/24 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  A61K31/505 ,  A61K31/506 ,  A61P11/06 ,  A61P17/04 ,  A61P19/02 ,  A61P1/00 ,  A61P25/00

CPC分类号： C07D213/30 ,  C07D239/30 ,  C07D239/32 ,  C07D239/34 ,  C07D239/42 ,  C07D239/52 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： Novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof are described. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell-damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors, and useful for treating PDE4 mediated diseases.

摘要翻译： 描述了通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药。 这些化合物可用于治疗免疫性疾病，炎症，疼痛障碍，类风湿性关节炎; 骨质疏松症 多发性骨髓瘤 葡萄膜炎 急性和慢性粒细胞白血病; 动脉粥样硬化 癌症; 恶病质 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏反应 接触性皮炎; 肌肉退化; 哮喘; COPD; 骨吸收疾病; 多发性硬化症 脓毒症 败血性休克 中毒性休克综合征和发烧。 更特别地，这些化合物可用作PDE4抑制剂，并且可用于治疗PDE4介导的疾病。

公开(公告)号：US20090136431A1

公开(公告)日：2009-05-28

申请号：US12084430

申请日：2006-11-06

申请人： Akella S.S.V. Srinivas ,  Urkalan K. Balan ,  Narayana S. Punthalir ,  Rama S. Velmurugan ,  Sriram Rajagopal ,  Gaddam O. Reddy ,  Virendra Kachhadia

发明人： Akella S.S.V. Srinivas ,  Urkalan K. Balan ,  Narayana S. Punthalir ,  Rama S. Velmurugan ,  Sriram Rajagopal ,  Gaddam O. Reddy ,  Virendra Kachhadia

IPC分类号： A61K9/12 ,  C07D417/04 ,  A61K31/427 ,  A61P35/00 ,  C12N5/06 ,  A61K31/4409 ,  C07D213/56

CPC分类号： C07C259/06 ,  C07C237/22 ,  C07C323/62 ,  C07D213/56 ,  C07D277/30 ,  C07D277/46 ,  C07D277/58 ,  C07D277/82 ,  C07D307/56 ,  C07D333/24 ,  C07D333/28 ,  C07D417/06

摘要： The present invention relates to novel stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel stilbene like compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I) as described above.

摘要翻译： 本发明涉及通式（I）的新颖的二苯乙烯类化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药。 本发明更具体地提供了通式（I）的新颖的二苯乙烯类化合物。 还包括在哺乳动物中治疗癌症，牛皮癣，增殖性病症和由HDAC介导的病症的方法，包括给予有效量的如上所述的新的式（I）化合物。

公开(公告)号：US20100329998A1

公开(公告)日：2010-12-30

申请号：US12863796

申请日：2009-01-30

申请人： Visweswara Akella Satya Surya Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Thirunavukkarasu Sappanimuthu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narasimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Om Gaddam ,  Nishikanth Reddy Gaddam ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam ,  Maruthikumar Narayanam ,  Sathyanarayana Gadde ,  Uma Ramachandran ,  Gopalan Balasubramanian ,  Narayanan Surendran ,  Shridhar Narayanan ,  Lolaknath Santosh Vishwakarma ,  Sanjeev Saxena

发明人： Visweswara Akella Satya Surya Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Thirunavukkarasu Sappanimuthu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narasimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Om Gaddam ,  Nishikanth Reddy Gaddam ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam ,  Maruthikumar Narayanam ,  Sathyanarayana Gadde ,  Uma Ramachandran ,  Gopalan Balasubramanian ,  Narayanan Surendran ,  Shridhar Narayanan ,  Lolaknath Santosh Vishwakarma ,  Sanjeev Saxena

IPC分类号： A61K9/12 ,  A61K31/505 ,  C07D239/02 ,  C07D401/14 ,  A61K31/506 ,  A61K31/497 ,  C07D417/04 ,  C07D403/04 ,  C07D413/12 ,  A61K31/5377 ,  A61K31/54 ,  A61P37/00 ,  A61P29/00 ,  A61P19/02 ,  A61P19/10 ,  A61P35/02 ,  A61P35/04 ,  A61P9/00 ,  A61P1/00 ,  A61P11/00

CPC分类号： C07D239/42 ,  A61K31/5377 ,  C07D265/28 ,  C07D401/04

摘要： Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases.

摘要翻译： 描述了通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药。 这些化合物可用于治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎; 骨质疏松症 多发性骨髓瘤 葡萄膜炎 急性和慢性粒细胞白血病; 动脉粥样硬化 癌症; 恶病质 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; ARDS; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏反应 接触性皮炎; 肌肉退化; 哮喘; COPD; 骨吸收疾病; 多发性硬化症 败血症 败血性休克 中毒性休克综合征和发烧。 更特别地，这些化合物可用作PDE4抑制剂，并且可用于治疗PDE4介导的疾病。

公开(公告)号：US20070167413A1

公开(公告)日：2007-07-19

申请号：US11633053

申请日：2006-12-04

申请人： Akella Satya Surya Visweswara Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Sappanimuthu Thirunavukkarasu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narsimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Gaddam Om Reddy ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam

发明人： Akella Satya Surya Visweswara Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Sappanimuthu Thirunavukkarasu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narsimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Gaddam Om Reddy ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam

IPC分类号： A61K31/655 ,  A61K31/506 ,  C07D403/04

CPC分类号： C07D239/42 ,  C07D213/30 ,  C07D239/32 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D417/12 ,  C07D417/14

摘要： The present invention relates to novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel hetereocycles of the general formula (I). Also included is a method of treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection in a mammal comprising administering an effective amount of a compound of formula (I) as described above.

摘要翻译： 本发明涉及通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂化物，药学上可接受的盐和组合物，其代谢物和前药。 本发明更具体地提供了通式（I）的新颖的杂环。 还包括治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎的方法; 骨质疏松症 多发性骨髓瘤 葡萄膜炎 急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化 癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏反应 接触性皮炎; 肌肉退化; 恶病质 哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症 脓毒症 败血性休克 中毒性休克综合征; 发热和由于哺乳动物感染引起的肌痛，包括给予有效量的如上所述的式（I）化合物。