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公开(公告)号：US20100222379A1
公开(公告)日：2010-09-02
申请号：US12734026
申请日：2008-10-08
申请人： Sridharan Rajagopal , Virendra Kachhadia , Thanasekaran Ponpandian , Abdul Raheem Keeri , Umamaheswari Mani , Suresh Rathinasamy , Praveen Rajendran , Kamaraj Mani , Balaji Ramachandran , Punthalir Narayanaswamy , Sriram Rajagopal
发明人： Sridharan Rajagopal , Virendra Kachhadia , Thanasekaran Ponpandian , Abdul Raheem Keeri , Umamaheswari Mani , Suresh Rathinasamy , Praveen Rajendran , Kamaraj Mani , Balaji Ramachandran , Punthalir Narayanaswamy , Sriram Rajagopal
IPC分类号： A61K31/167 , C07C237/40 , C07D215/38 , A61K31/47 , A61P35/00
CPC分类号： C07C237/42 , C07C237/22 , C07C259/06 , C07C259/10 , C07C271/22 , C07C275/50 , C07C2601/02 , C07D213/56 , C07D215/14 , C07D317/60 , C07D333/24 , C07D333/44
摘要： Provided herein are novel, stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, metabolites, prodrugs, solvates, pharmaceutically acceptable salts and compositions thereof. These compounds can inhibit HDACs and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as WO 2009/047615 A2 malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, etc.
摘要翻译： 本文提供了新颖的通式（I）的二苯乙烯类化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，代谢物，前药，溶剂化物，药学上可接受的盐和组合物。 这些化合物可以抑制HDAC，并且可用作涉及细胞生长的疾病的治疗或改善剂，例如WO 2009/047615A2恶性肿瘤，自身免疫性疾病，皮肤病，感染，炎症等。
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公开(公告)号：US08476255B2
公开(公告)日：2013-07-02
申请号：US12734026
申请日：2008-10-08
申请人： Sridharan Rajagopal , Virendra Kachhadia , Thanasekaran Ponpandian , Abdul Raheem Keeri , Umamaheswari Mani , Suresh Rathinasamy , Praveen Rajendran , Kamaraj Mani , Balaji Ramachandran , Punthalir Narayanaswamy , Sriram Rajagopal
发明人： Sridharan Rajagopal , Virendra Kachhadia , Thanasekaran Ponpandian , Abdul Raheem Keeri , Umamaheswari Mani , Suresh Rathinasamy , Praveen Rajendran , Kamaraj Mani , Balaji Ramachandran , Punthalir Narayanaswamy , Sriram Rajagopal
IPC分类号： A01N43/00 , A61K31/33 , A61K31/16 , A01N37/18 , C07D215/38
CPC分类号： C07C237/42 , C07C237/22 , C07C259/06 , C07C259/10 , C07C271/22 , C07C275/50 , C07C2601/02 , C07D213/56 , C07D215/14 , C07D317/60 , C07D333/24 , C07D333/44
摘要： Provided herein are novel, stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, metabolites, prodrugs, solvates, pharmaceutically acceptable salts and compositions thereof. These compounds can inhibit HDACs and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, etc.
摘要翻译： 本文提供了新颖的通式（I）的二苯乙烯类化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，代谢物，前药，溶剂合物，药学上可接受的盐和组合物。 这些化合物可以抑制HDAC，并且可用作涉及细胞生长的疾病如恶性肿瘤，自身免疫性疾病，皮肤病，感染，炎症等的治疗或改善剂。
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公开(公告)号：US20050060088A1
公开(公告)日：2005-03-17
申请号：US10889156
申请日：2004-07-12
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/024 , A61B5/053 , A61B5/08 , A61B5/11 , G01C21/00 , G01C21/20 , G01C21/34 , G05B19/00 , G05B19/042 , G06F15/16 , G06F19/00 , G06Q50/00 , G08B1/08 , G08B25/00 , G08B25/01 , G08B25/08 , G08B27/00 , G08C17/00 , G08C17/02 , H04B7/00 , H04L12/28 , H04M1/247 , H04M1/725
CPC分类号： G08B13/19684 , A61B5/002 , A61B5/0022 , A61B5/0062 , A61B5/02055 , A61B5/024 , A61B5/0531 , A61B5/0816 , A61B5/1112 , A61B5/1113 , A61B5/411 , A61B5/7475 , A61B2503/08 , A61B2560/0242 , A61B2560/0468 , G01C21/005 , G01C21/20 , G05B19/042 , G06F15/16 , G06F19/3418 , G06Q10/10 , G06Q10/109 , G06Q50/00 , G06Q90/00 , G08B13/19658 , G08B13/19697 , G08B21/025 , G08B21/0263 , G08B21/0275 , G08B21/028 , G08B21/0283 , G08B21/04 , G08B25/008 , G08B25/009 , G08B25/016 , G08B27/006 , G08C17/00 , G08C17/02 , G08C2201/41 , G08C2201/42 , G08C2201/50 , G08C2201/51 , G08C2201/61 , G08C2201/93 , G16H40/63 , H04L12/2803 , H04L12/282 , H04L12/2836 , H04M1/7253 , H04M1/72533 , H04M1/72566 , H04M1/72569 , H04M1/72572 , H04M1/72588 , H04M2250/12
摘要： A pedestrian navigation and spatial relation device including a position finder, a spatial relationship sensor, an input mechanism, and an output mechanism. The position finder can be configured to determine a geographic position of the device based upon received wireless signals. The spatial relationship sensor can provide data used to detect a position of at least one obstacle relative to the device. The input mechanism can specify a destination location. The output mechanism can present device output to a user. The device output can include sensory indicators for at least one of guiding a pedestrian to the destination location and warning a pedestrian about the detected obstacles.
摘要翻译： 包括定位器，空间关系传感器，输入机构和输出机构的行人导航和空间关系装置。 位置查找器可以被配置为基于接收到的无线信号来确定设备的地理位置。 空间关系传感器可以提供用于检测相对于设备的至少一个障碍物的位置的数据。 输入机制可以指定目的地位置。 输出机制可以向用户显示设备输出。 设备输出可以包括用于将行人引导到目的地位置的至少一个的感觉指示符，并且警告行人关于检测到的障碍物。
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公开(公告)号：US20080005733A1
公开(公告)日：2008-01-03
申请号：US11478762
申请日：2006-06-29
IPC分类号： G06F9/44
CPC分类号： G06F8/65
摘要： A computer implemented method for updating one or a combination of the system software, operating systems, device configuration, application software and firmware of electronic devices via geographically located local communication points likely to be proximate to the electronic device being updated. The communication points are connected to local servers which communicate stored update packages to the electronic device which are pre-provided by the device manufacturers, or customize update packages to the device subsequent to a query response as to the state of software, firmware, and configuration of the device to be updated.
摘要翻译： 一种计算机实现的方法，用于通过可能接近被更新的电子设备的地理位置的本地通信点来更新系统软件，操作系统，设备配置，应用软件和电子设备的固件的一个或其组合。 通信点连接到本地服务器，其将存储的更新包与设备制造商预先提供的电子设备通信，或者在关于软件，固件和配置的状态的查询响应之后定制到设备的更新包 的设备进行更新。
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