公开(公告)号：US20120100157A1

公开(公告)日：2012-04-26

申请号：US13270686

申请日：2011-10-11

申请人： George F. Vande Woude ,  Qian Xie

发明人： George F. Vande Woude ,  Qian Xie

IPC分类号： A61K39/395 ,  G01N21/64 ,  G01N21/76 ,  A61P35/00 ,  C12Q1/68 ,  C40B30/00 ,  C40B30/04 ,  G01N33/566 ,  G01N33/82

CPC分类号： G01N33/57484 ,  G01N33/57407 ,  G01N2333/71 ,  G01N2800/52

摘要： Methods for determining the responsiveness of a Met-related cancer in a subject to treatment with a Met inhibitor. Kits for performing the disclosed methods are also provided. The present invention also provides a method of treating glioblastomamultiforme (GBM) in a subject in need thereof, the method comprises administering a therapeutically effective dose of a Met inhibitor in combination with a therapeutically effective dose of a epithelial growth factor receptor (EGFR) inhibitor.

摘要翻译： 用于测定受试者中Met相关癌症对Met抑制剂治疗的反应性的方法。 还提供了用于执行所公开的方法的套件。 本发明还提供在有需要的受试者中治疗胶质母细胞瘤菌（GBM）的方法，该方法包括与治疗有效剂量的上皮生长因子受体（EGFR）抑制剂组合施用治疗有效剂量的Met抑制剂。

公开(公告)号：US20070297980A1

公开(公告)日：2007-12-27

申请号：US10594136

申请日：2005-03-28

申请人： Qian Xie ,  David Wenkert ,  Yuchai Shen ,  George Vande Woude ,  Ricky Hay

发明人： Qian Xie ,  David Wenkert ,  Yuchai Shen ,  George Vande Woude ,  Ricky Hay

IPC分类号： A61K31/395 ,  A61K31/397 ,  A61K51/04 ,  A61P35/00 ,  A61P35/04 ,  C07D225/06

CPC分类号： C07D225/06

摘要： Geldanamycin derivatives that block the uPA-plasmin network and inhibit growth and invasion by glioblastoma cells and other tumors at femtomolar concentrations are potentially highly active anti-cancer drugs. GA and various 17-amino-17-demethoxygelddanamycin derivatives are disclosed that block HGF/SF-mediated Met tyrosine kinase receptor-dependent uPA activation at fM levels. Other ansamycins (macbecins I and II), GA derivatives, and radicicol required concentrations several logs higher (≧nM) to achieve such inhibition. The inhibitory activity of tested compounds was discordant with the known ability of drugs of this class to bind to hsp90, indicating the existence of a novel target(s) for HGF/SF-mediated events in tumor development. Methods of using such compounds to inhibit cancer cell activities and to treat tumors are disclosed. Such treatment with low doses of these highly active compounds provide an option for treating various Met-expressing tumors, in particular invasive brain cancers, either alone or in combination with conventional surgery, chemotherapy, or radiotherapy.

摘要翻译： 阻断uPA-纤溶酶网络并抑制成胶质细胞瘤细胞和其他肿瘤在飞生物浓度下的生长和侵袭的格尔德霉素衍生物是潜在的高活性抗癌药物。 GA和各种17-氨基-17-脱甲氧基格丹丹霉素衍生物被公开，以fM水平阻断HGF / SF介导的Met酪氨酸激酶受体依赖性uPA活化。 其他ansamycins（macbecins I和II），GA衍生物和radicicol要求的浓度几个日志更高（> = nM）达到这种抑制。 测试化合物的抑制活性与本类药物已知的与hsp90结合的能力不一致，表明在肿瘤发展中存在HGF / SF介导的事件的新靶标。 公开了使用这些化合物抑制癌细胞活性和治疗肿瘤的方法。 用低剂量的这些高活性化合物的这种治疗提供了单独或与常规手术，化学疗法或放射疗法组合治疗各种Met表达肿瘤，特别是侵袭性脑癌的选择。

公开(公告)号：US20050031025A1

公开(公告)日：2005-02-10

申请号：US10635525

申请日：2003-08-07

申请人： Qian Xie ,  Huaiyu Zeng

发明人： Qian Xie ,  Huaiyu Zeng

IPC分类号： H04L1/00 ,  H04B1/38

CPC分类号： H04L1/0057 ,  H04L1/0046 ,  H04L1/0054

摘要： Methods and systems provide for operating a modem receiver such as an ADSL modem receiver. As incoming data signals are received, a decoding scheme is selected from a plurality of decoding schemes based on a predetermined downstream data rate. In one approach a soft receiver architecture of an ADSL modem is able to select between relatively complex decoding schemes and relatively simple decoding schemes based on signal-to-noise ratio (SNR).

摘要翻译： 方法和系统提供操作诸如ADSL调制解调器接收机的调制解调器接收机。 当接收到输入数据信号时，基于预定的下行数据速率从多个解码方案中选择解码方案。 在一种方法中，ADSL调制解调器的软接收器架构能够基于信噪比（SNR）在相对复杂的解码方案和相对简单的解码方案之间进行选择。

公开(公告)号：US07254165B2

公开(公告)日：2007-08-07

申请号：US10635525

申请日：2003-08-07

申请人： Qian Xie ,  Huaiyu Zeng

发明人： Qian Xie ,  Huaiyu Zeng

IPC分类号： H04B1/38 ,  H04L5/16

CPC分类号： H04L1/0057 ,  H04L1/0046 ,  H04L1/0054

摘要： Methods and systems provide for operating a modem receiver such as an ADSL modem receiver. As incoming data signals are received, a decoding scheme is selected from a plurality of decoding schemes based on a predetermined downstream data rate. In one approach a soft receiver architecture of an ADSL modem is able to select between relatively complex decoding schemes and relatively simple decoding schemes based on signal-to-noise ratio (SNR).

摘要翻译： 方法和系统提供操作诸如ADSL调制解调器接收机的调制解调器接收机。 当接收到输入数据信号时，基于预定的下行数据速率从多个解码方案中选择解码方案。 在一种方法中，ADSL调制解调器的软接收器架构能够基于信噪比（SNR）在相对复杂的解码方案和相对简单的解码方案之间进行选择。