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    MUC16 MONOCLONAL ANTIBODY AND USES THEREOF
    2.
    发明申请
    MUC16 MONOCLONAL ANTIBODY AND USES THEREOF 有权

    公开(公告)号：US20210101994A1

    公开(公告)日：2021-04-08

    申请号：US17048119

    申请日：2019-04-30

    申请人： QUEST PHARMATECH INC.

    发明人： Ragupathy Madiyalakan ,  Michael Hollingsworth ,  Prakash Radhakrishnan

    IPC分类号： C07K16/30

    摘要： The present document describes an antibody or an antigen-binding fragment that bind to O-glycan mucin-type glycoprotein MUC16 comprising three variable heavy domain complementarity determining regions (CDR)(CDR H1, H2 and H3), and three variable lighy domain CDR (CDR L1, L2 and L3). The present invention also relates to pharmaceutical compositions, nucleic acid vectors, cells comprising the nucleic acid vectors, and methods of inhibiting tumor growth of a tumor expressing O-glycan mucin-type glycoprotein MUC16.

    PERYLENEQUINONE DERIVATIVES AND USES THEREOF
    3.
    发明申请
    PERYLENEQUINONE DERIVATIVES AND USES THEREOF 有权
    季戊四醇衍生物及其用途

    公开(公告)号：US20130304089A1

    公开(公告)日：2013-11-14

    申请号：US13792456

    申请日：2013-03-11

    申请人： QUEST PHARMATECH INC.

    发明人： Sanjay K. Sharma ,  Thomas Woo ,  Selvaraj Naicker

    IPC分类号： A61K41/00

    CPC分类号： C07C229/74 ,  A61K8/415 ,  A61K8/492 ,  A61K41/0033 ,  A61K41/0057 ,  A61K49/00 ,  A61K2800/434 ,  A61Q9/04 ,  C07C225/32 ,  C07C2603/54 ,  C07D209/94 ,  C07D241/38 ,  C07D241/52

    摘要： The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or sononsensitizers in photodynamic or sonodynamic therapy. The invention also relates to various methods for using these compounds in photodynamic and/or sonodynamic therapy. The compounds also are useful as therapeutic agents for treating various hyperproliferative disorders.

    摘要翻译： 本发明涉及苝醌衍生物，其立体异构体和阻转异构体的化合物。 这些化合物在光动力学或儿子动力学治疗中可以特别用作光敏剂或超声敏剂。 本发明还涉及在光动力学和/或超声动力学治疗中使用这些化合物的各种方法。 所述化合物还可用作治疗各种过度增殖性疾病的治疗剂。