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    Use of fumaric acid derivatives for treating cardiac insufficiency, and asthma
    4.
    发明授权
    Use of fumaric acid derivatives for treating cardiac insufficiency, and asthma 有权
    使用富马酸衍生物治疗心功能不全和哮喘

    公开(公告)号：US08980832B2

    公开(公告)日：2015-03-17

    申请号：US12884573

    申请日：2010-09-17

    Applicant: Rajendra Kumar Joshi ,  Hans-Peter Strebel ,  Christian Zaugg ,  Michael Tamm

    Inventor： Rajendra Kumar Joshi ,  Hans-Peter Strebel ,  Christian Zaugg ,  Michael Tamm

    IPC: A61P9/00 ,  A61K31/231 ,  A61K31/573

    CPC classification number: A61K31/225 ,  A61K31/197 ,  A61K31/231 ,  A61K31/573 ,  A61K2300/00

    Abstract: According to a first aspect the invention relates to the use of fumaric acid derivatives selected from the group consisting of dialkyl fumarates, monoalkyl hydrogen fumarates, fumaric acid monoalkyl ester salts, fumaric acid monoamides, monoamido fumaric acid salts, fumaric acid diamides, monoalkyl monoamido fumarates, carbocyclic and oxacarbocyclic oligomers of these compounds and mixtures thereof for preparing a drug for the treatment or prevention of cardiac insufficiency, in particular left ventricular insufficiency, myocardial infarction and angina pectoris.According to a second aspect the invention relates to the use of fumaric acid derivatives, selected from the group consisting of dialkyl fumarates, monoalkyl hydrogen fumarates, fumaric acid monoalkyl ester salts, fumaric acid monoamides, monoamido fumaric acid salts, fumaric acid diamides, monoalkyl monoamido fumarates, carbocyclic and oxacarbocyclic oligomers of these compounds and mixtures thereof for preparing a drug for the treatment of asthma and chronic obstructive pulmonary diseases, especially asthma caused by allergies, infections, analgesics, job conditions or physical effort, mixed forms of asthma, or asthma cardiale.

    Abstract translation: 根据第一方面，本发明涉及富马酸衍生物的用途，所述富马酸衍生物选自富马酸二烷基酯，富马酸单烷基酯，富马酸单烷基酯盐，富马酸单酰胺，单酰氨基富马酸盐，富马酸二酰胺，单烷基单酰氨基富马酸盐 这些化合物的碳环和氧杂环低聚物及其混合物，用于制备用于治疗或预防心功能不全，特别是左心室功能不全，心肌梗死和心绞痛的药物。 根据第二方面，本发明涉及富马酸衍生物的用途，所述富马酸衍生物选自富马酸二烷基酯，富马酸单烷基酯，富马酸单烷基酯盐，富马酸单酰胺，单酰基富马酸盐，富马酸二酰胺，单烷基单酰胺基 这些化合物的富马酸盐，碳环和氧杂环低聚物及其混合物，用于制备用于治疗哮喘和慢性阻塞性肺疾病的药物，特别是由过敏，感染，止痛剂，工作条件或体力，哮喘或哮喘混合形式引起的哮喘 心脏病

    Fumaric acid amides
    9.
    发明授权
    Fumaric acid amides 有权
    富马酸酰胺

    公开(公告)号：US07432240B2

    公开(公告)日：2008-10-07

    申请号：US11421083

    申请日：2006-05-31

    Applicant: Rajendra Kumar Joshi ,  Hans-Peter Strebel

    Inventor： Rajendra Kumar Joshi ,  Hans-Peter Strebel

    IPC: A61K38/00 ,  A61K38/02 ,  C07K2/00 ,  C07K1/107

    CPC classification number: A61K31/198 ,  A61K31/194 ,  A61K31/225

    Abstract: Fumaric acid amides of the general formula (I) wherein R1 represents OR3 or a D- or L-amino acid radical —NH—CHR4—COOH bonded via an amide bond, wherein R3 is hydrogen, a straight-chained or branched, optionally substituted C1-24 alkyl radical, a phenyl radical or C6-10 aralkyl radical and R4 is a side chain of a natural or synthetic amino acid and R2 represents a D- or L-amino acid radical —NH—CHR5—COOH bonded via an amide bond or a peptide radical comprising 2 to 100 amino acids bonded via an amide bond, wherein R5 is a side chain of a natural or synthetic amino acid, are used for preparing a drug (1) for the therapy of an autoimmune disease; (2) for use in transplantation medicine; (3) for the therapy of mitochondrial diseases; or (4) for the therapy of NF-kappaB mediated diseases.

    Abstract translation: 通式（I）的富马酸酰胺，其中R 1代表OR 3或D或L-氨基酸基-NH-CHR 4， 其中R 3是氢，直链或支链的任选取代的C 1-24烷基，苯基或 C 6-10芳烷基和R 4是天然或合成氨基酸的侧链，R 2表示D-或L 通过酰胺键或包含通过酰胺键键合的2至100个氨基酸的肽基键合的氨基酸基-NH-CHR 5 -COOH，其中R 5为 天然或合成氨基酸的侧链用于制备用于治疗自身免疫性疾病的药物（1）; （2）用于移植药物; （3）治疗线粒体疾病; 或（4）用于治疗NF-kappaB介导的疾病。

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