公开(公告)号：US06838581B2

公开(公告)日：2005-01-04

申请号：US10309010

申请日：2002-12-04

Applicant: Pradeep Kumar ,  Rajesh Kumar Pandey

Inventor： Pradeep Kumar ,  Rajesh Kumar Pandey

IPC: C07C215/30 ,  C07C213/02

CPC classification number: C07C215/30 ,  C07B2200/07 ,  Y02P20/582

Abstract: The present invention relates to an improved process for the synthesis of enantiomerically pure 3-phenyl-3-hydroxypropylamine of formula I; more particularly the present invention relates to the said process using styrene; the synthetic strategy features a Sharpless asymmetric dihydroxylation (SAD) route to the target compound, using styrene, a readily accessible starting material gives the optically pure dihydroxy compound (ee >97%; the selective monotosylation of primary alcohol, nucleophilic displacement by cyano and subsequent reduction to amino group furnishes the desired 3-phenyl-3-hydroxypropylamine in enatiomerically pure form, a key intermediate in the synthesis of variety of oxetine related anti-depressant drugs.

公开(公告)号：US09250238B2

公开(公告)日：2016-02-02

申请号：US13805770

申请日：2011-06-24

Applicant: Philip S. Low ,  Alexander Wei ,  Ronald G. Reifenberger ,  Youngsoon Kim ,  Avijit Kumar Adak ,  David Lyvers ,  Kulbhushan Durugkar ,  Derek Doorneweerd ,  Rajendra P. Bandari ,  Rajesh Kumar Pandey ,  Alexei Leonov ,  Walter A. Henne ,  Yeong E. Kim

Inventor： Philip S. Low ,  Alexander Wei ,  Ronald G. Reifenberger ,  Youngsoon Kim ,  Avijit Kumar Adak ,  David Lyvers ,  Kulbhushan Durugkar ,  Derek Doorneweerd ,  Rajendra P. Bandari ,  Rajesh Kumar Pandey ,  Alexei Leonov ,  Walter A. Henne ,  Yeong E. Kim

IPC: C40B40/02 ,  G01N33/569 ,  G01N33/543 ,  G01N33/53 ,  B03C5/00 ,  B03C5/02 ,  G01N35/00

CPC classification number: G01N33/569 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  C40B40/02 ,  G01N33/5302 ,  G01N33/5308 ,  G01N33/54353 ,  G01N33/56905 ,  G01N33/56911 ,  G01N33/56961 ,  G01N33/56983 ,  G01N2035/00158

Abstract: Pathogens are detected through the use of mutation-resistant ligands.

Abstract translation: 通过使用突变抗性配体检测病原体。