公开(公告)号：US20180045681A1

公开(公告)日：2018-02-15

申请号：US15682070

申请日：2017-08-21

Applicant: Shyam S. Mohapatra ,  Subhra Mohapatra ,  Rasim Oytun Guldiken ,  Rajesh R. Nair

Inventor： Shyam S. Mohapatra ,  Subhra Mohapatra ,  Rasim Oytun Guldiken ,  Rajesh R. Nair

IPC: G01N29/02 ,  G01N29/036

Abstract: A novel SH-SAW biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2D) and three-dimensional (3D) cell cultures as well as stem cell regeneration as it pertains to cancer cell biology and anti-cancer drug development is presented. The biosensor includes two pairs of resonators including interdigital transducers reflecting fingers to quantify mass loading by the cells in suspension as well as within a tumoroid culture platform. The biosensor can be part of a perfused 3PNS-tumoroid system that is amenable to real-time non-invasive monitoring of the cell proliferation, viability, and multiplexed detection of key physiologic and clinical biomarkers.

公开(公告)号：US11016062B2

公开(公告)日：2021-05-25

申请号：US16722210

申请日：2019-12-20

Applicant: Shyam S. Mohapatra ,  Subhra Mohapatra ,  Rasim Oytun Guldiken ,  Rajesh R. Nair ,  Tao Wang

Inventor： Shyam S. Mohapatra ,  Subhra Mohapatra ,  Rasim Oytun Guldiken ,  Rajesh R. Nair ,  Tao Wang

IPC: G01N29/02 ,  G01N29/036 ,  G01N29/22 ,  G01N29/24 ,  G01N33/48

Abstract: A novel SH-SAW biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2D) and three-dimensional (3D) cell cultures as well as stem cell regeneration as it pertains to cancer cell biology and anti-cancer drug development is presented. The biosensor includes two pairs of resonators including interdigital transducers reflecting fingers to quantify mass loading by the cells in suspension as well as within a tumoroid culture platform. The biosensor can be part of a perfused 3PNS-tumoroid system that is amenable to real-time non-invasive monitoring of the cell proliferation, viability, and multiplexed detection of key physiologic and clinical biomarkers.

公开(公告)号：US10520472B2

公开(公告)日：2019-12-31

申请号：US15682070

申请日：2017-08-21

Applicant: Shyam S. Mohapatra ,  Subhra Mohapatra ,  Rasim Oytun Guldiken ,  Rajesh R. Nair ,  Tao Wang

Inventor： Shyam S. Mohapatra ,  Subhra Mohapatra ,  Rasim Oytun Guldiken ,  Rajesh R. Nair ,  Tao Wang

IPC: G01N29/02 ,  G01N29/036 ,  G01N33/48 ,  G01N29/24 ,  G01N29/22

Abstract: A novel SH-SAW biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2D) and three-dimensional (3D) cell cultures as well as stem cell regeneration as it pertains to cancer cell biology and anti-cancer drug development is presented. The biosensor includes two pairs of resonators including interdigital transducers reflecting fingers to quantify mass loading by the cells in suspension as well as within a tumoroid culture platform. The biosensor can be part of a perfused 3PNS-tumoroid system that is amenable to real-time non-invasive monitoring of the cell proliferation, viability, and multiplexed detection of key physiologic and clinical biomarkers.