公开(公告)号：US20150038671A1

公开(公告)日：2015-02-05

申请号：US14292745

申请日：2014-05-30

Applicant: Keykavous Parang ,  Rakesh Tiwari

Inventor： Keykavous Parang ,  Rakesh Tiwari

IPC: C07K7/56

CPC classification number: C07K7/56 ,  C07K7/06

Abstract: Synthesized macrocyclic ligand, CN2097 and analogs, optimized with systemic structure modifications to develop the compounds with lower molecular weights and less peptidic characters.

Abstract translation: 合成的大环配体CN2097和类似物，用系统结构修饰进行优化，以开发具有较低分子量和较少肽性质的化合物。

公开(公告)号：US20230000999A1

公开(公告)日：2023-01-05

申请号：US17788954

申请日：2020-12-24

Applicant: Keykavous PARANG ,  Hamidreza MONTAZERI ALIABADI ,  Dindyal MANDAL ,  Eman MOHAMMED ,  Saghar MOZAFFARI ,  Sandeep LOHAN ,  Rakesh TIWARI ,  Ryley HALL ,  AJK BIOPHARMACEUTICAL, LLC

Inventor： Keykavous PARANG ,  Hamidreza MONTAZERI ALIABADI ,  Dindyal MANDAL ,  Eman MOHAMMED ,  Saghar MOZAFFARI ,  Sandeep LOHAN ,  Rakesh TIWARI ,  Ryley HALL

IPC: A61K47/64 ,  C07K7/08 ,  C07K7/06 ,  C07K7/64 ,  A61K48/00 ,  A61K47/69 ,  C12N15/113 ,  C12N15/11 ,  A61P35/00 ,  A61K8/64 ,  A61Q19/00 ,  A61K8/60 ,  A61K47/60

Abstract: Peptide-based systems containing hydrophobic amino acids (e.g., tryptophan), charged amino acids (e.g., arginine), and/or sulfur-containing amino acids (e.g., cysteine), which can be used either alone or in combination with nanoparticles (e.g., gold or silver nanoparticles) for siRNA delivery into living cells are disclosed.