公开(公告)号：US20160009727A1

公开(公告)日：2016-01-14

申请号：US14772327

申请日：2014-02-27

Applicant: John S. KOVACH ,  Francis JOHNSON ,  Ramakrishna SAMUDRALA

Inventor： John S. KOVACH ,  Francis JOHNSON ,  Ramakrishna SAMUDRALA

IPC: C07D491/153

CPC classification number: C07D491/153 ,  C07D217/22 ,  C07D221/18 ,  C07D317/68 ,  C07D491/056

Abstract: Sanguinarine analogs as PP2C inhibitors are disclosed for the treatment of various cancers, as well as methods of synthesizing such analogs.

Abstract translation: 公开了作为PP2C抑制剂的血根类似物用于治疗各种癌症，以及合成此类类似物的方法。

公开(公告)号：US20170240558A1

公开(公告)日：2017-08-24

申请号：US15589485

申请日：2017-05-08

Applicant: John S. KOVACH ,  Francis JOHNSON ,  Ramakrishna SAMUDRALA

Inventor： John S. KOVACH ,  Francis JOHNSON ,  Ramakrishna SAMUDRALA

IPC: C07D491/153

CPC classification number: C07D491/153 ,  C07D217/22 ,  C07D221/18 ,  C07D317/68 ,  C07D491/056

Abstract: Sanguinarine analogs as PP2C inhibitors are disclosed for the treatment of various cancers, as well as methods of synthesizing such analogs.

公开(公告)号：US20160264593A1

公开(公告)日：2016-09-15

申请号：US15036760

申请日：2014-11-14

Applicant: John S. Kovach ,  Francis Johnson ,  Ramakrishna Samudrala ,  Ramesh C. Gupta

Inventor： John S. Kovach ,  Francis Johnson ,  Ramakrishna Samudrala ,  Ramesh C. Gupta

IPC: C07D493/08 ,  C07F9/6561

CPC classification number: C07D493/08 ,  A61K31/4178 ,  A61K31/4433 ,  A61K31/496 ,  A61K45/06 ,  C07F9/6561 ,  A61K2300/00

Abstract: The present invention provides a method for in vivo delivery of endothal to a target cell in a subject, the method comprising administering to the subject a compound having the structure: Formula (I).