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    BIDENTATE CHIRAL LIGANDS FOR USE IN CATALYTIC ASYMMETRIC ADDITION REACTIONS
    2.
    发明申请
    BIDENTATE CHIRAL LIGANDS FOR USE IN CATALYTIC ASYMMETRIC ADDITION REACTIONS 有权
    用于催化不对称添加反应的双歧杆菌配体

    公开(公告)号：US20110118482A1

    公开(公告)日：2011-05-19

    申请号：US12734696

    申请日：2008-11-14

    申请人： Benoît Pugin ,  Matthias Lotz ,  Heidi Landert ,  Adrian Wyss ,  Raphael Aardoom ,  Bjõrn Gschwend ,  Andreas Pfaltz ,  Felix Spindler

    发明人： Benoît Pugin ,  Matthias Lotz ,  Heidi Landert ,  Adrian Wyss ,  Raphael Aardoom ,  Bjõrn Gschwend ,  Andreas Pfaltz ,  Felix Spindler

    IPC分类号： C07F9/6553 ,  C07F15/00 ,  C07F17/02 ,  C07F9/28 ,  C07F9/655 ,  C07C67/00 ,  C07C227/16

    CPC分类号： C07F13/005 ,  B01J31/1875 ,  B01J31/2291 ,  B01J31/2495 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/0238 ,  B01J2531/822 ,  B01J2531/827 ,  C07B53/00 ,  C07B2200/07 ,  C07C67/303 ,  C07C67/31 ,  C07C231/12 ,  C07C231/18 ,  C07F9/46 ,  C07F9/5004 ,  C07F9/5018 ,  C07F9/5022 ,  C07F9/5027 ,  C07F9/65515 ,  C07F9/65517 ,  C07F9/65522 ,  C07F9/655354 ,  C07F17/02 ,  C07C69/34 ,  C07C69/732 ,  C07C69/675 ,  C07C233/47

    摘要： Compounds of the formula (I), in the form of mixtures comprising predominantly one diastereomer or in the form of pure diastereomers, Z1-Q-P*R0R1 (I) in which Z1 is a C-bonded, secondary phosphine group —P(R)2; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals, or Z1 is the —P*R0R1 group; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C1-C4-alkylene skeleton, and in which base skeletons a secondary phosphine group Z1 is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group, and in which base skeletons a P-chiral group —P*R0R1 is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group to a carbon atom such that the phosphorus atoms are linked via 1 to 7 atoms of a carbon chain optionally interrupted by heteroatoms from the group of O, S, N, Fe or Si; P* is a chiral phosphorus atom; R0 is methyl or hydroxyl, and R0 is methyl when Z1 is the —P*R0R1 group; and R1 is a C-bonded optically enriched or optically pure chiral, mono- or polycyclic, nonaromatic hydrocarbon or heterohydrocarbon radical which has 3 to 12 ring atoms and 1 to 4 rings and which has a stereogenic carbon atom at least in the a position to the P—C bond; Metal complexes of these ligands are homogeneous catalysts for asymmetric addition reactions, particularly hydrogenations.

    摘要翻译： 主要为一种非对映体或纯非对映体形式的混合物形式的式（I）化合物，其中Z 1为C键，仲膦基-P（R）的Z1-QP * R0R1（I） 2; 其中R各自独立地为烃基或杂烃基，或Z1为-P * R0R1基团; Q是二价，非手性，芳族碱基骨架，二价，非手性二茂铁碱骨架，任选取代的二价环烷烃或杂环烷骨架，或C1-C4-亚烷基骨架，其中，基骨架中的次膦基Z1直接键合 或在环状基团骨架的情况下直接与碳原子或C 1 -C 4 - 亚烷基直接键合，并且其中的基础骨架中，P手性基团-P * R0R1直接键合到碳上 或者在环状基骨架的情况下，直接连接到碳原子上，或者通过C1-C4-亚烷基与碳原子连接，使得磷原子通过1至7个任选被杂原子中断的碳链原子连接 由O，S，N，Fe或Si组成; P *是手性磷原子; R 0是甲基或羟基，当Z 1是-P * R 0 R 1基团时，R 0是甲基; 并且R 1是C-键合的光学富集或光学纯的手性，单或多环，非芳族烃或杂烃基，其具有3至12个环原子和1至4个环，并且其具有立体碳原子至少在 P-C键; 这些配体的金属络合物是用于不对称加成反应的均相催化剂，特别是氢化。