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    Cyclopropenylidene-stabilized phosphenium cations
    3.
    发明授权
    Cyclopropenylidene-stabilized phosphenium cations 有权
    环丙烯亚基稳定磷鎓阳离子

    公开(公告)号：US08981126B2

    公开(公告)日：2015-03-17

    申请号：US14000997

    申请日：2012-02-23

    申请人： Manuel Alcarazo ,  Hans Bruns ,  Jekaterina Petuskova

    发明人： Manuel Alcarazo ,  Hans Bruns ,  Jekaterina Petuskova

    IPC分类号： C07D311/94 ,  C07F9/50 ,  B01J31/24 ,  C07F15/00 ,  C07F1/12

    CPC分类号： C07F9/5018 ,  B01J31/2404 ,  B01J2231/4211 ,  B01J2231/52 ,  B01J2531/18 ,  B01J2531/822 ,  B01J2531/847 ,  C07D311/94 ,  C07F1/12 ,  C07F9/02 ,  C07F9/50 ,  C07F9/5022 ,  C07F15/00 ,  C07F15/0073 ,  C07F15/0093

    摘要： Phosphenium compounds with the general formula I: in which R1, R2, R3 and R4 are identical or different and represent a linear or branched C1-C6-alkyl radical, which can optionally be substituted, or R1 and R2 and/or R3 and R4 are bonded to one another with the formation of a ring, R5 and R6 stand for a saturated or unsaturated and linear or branched alkyl group, alkenyl group or aryl group, which can have suitable substituents, even heteroatoms as substituents, or a heteroatom-comprising hydrocarbon group, which can have suitable substituents, and the R5 and R6 radicals can form a ring which can be 4- to 20-membered, saturated or unsaturated and alicyclic or heteroalicyclic and can exhibit suitable substituents, X− represents an anion, a process for the preparation thereof, and also the use of these compounds in metal complexes which can be used as catalysts in organic synthesis, are claimed.

    摘要翻译： 具有通式I的磷酸酯化合物，其中R 1，R 2，R 3和R 4相同或不同，表示可任选被取代的直链或支链C 1 -C 6烷基，或R 1和R 2和/或R 3和R 4 形成环，R5和R6表示饱和或不饱和的直链或支链烷基，烯基或芳基，其可以具有合适的取代基，甚至杂原子作为取代基，或含杂原子的 烃基，其可以具有合适的取代基，并且R 5和R 6基团可以形成可以是4-至20-元饱和或不饱和和脂环族或杂脂环的环并且可以表现出合适的取代基，X-表示阴离子， 为了制备它们，还要求使用这些化合物在可用作有机合成中的催化剂的金属络合物中。

    Bidentate secondary phosphine oxide chiral ligands for use in asymmetric addition reactions
    4.
    发明授权
    Bidentate secondary phosphine oxide chiral ligands for use in asymmetric addition reactions 失效
    用于不对称加成反应的二齿次膦氧化物手性配体

    公开(公告)号：US08415488B2

    公开(公告)日：2013-04-09

    申请号：US12734726

    申请日：2008-11-14

    申请人： Benoît Pugin ,  Heidi Landert ,  Björn Gschwend ,  Andreas Pfaltz ,  Felix Spindler

    发明人： Benoît Pugin ,  Heidi Landert ,  Björn Gschwend ,  Andreas Pfaltz ,  Felix Spindler

    IPC分类号： C07D333/62

    CPC分类号： C07F9/65517 ,  B01J31/2495 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/822 ,  B01J2531/827 ,  C07B53/00 ,  C07B2200/07 ,  C07C67/303 ,  C07C67/31 ,  C07C213/02 ,  C07C231/12 ,  C07C231/18 ,  C07F9/46 ,  C07F9/5018 ,  C07F9/5022 ,  C07F9/655354 ,  C07C69/34 ,  C07C69/732 ,  C07C69/675 ,  C07C217/08 ,  C07C233/47

    摘要： Compounds of the formula I, in the form of mixtures comprising predominantly one enantiomer or in the form of pure enantiomers, secondary phosphine-Q-P*(═O)HR1 (I) in which secondary phosphine is a C-bonded, secondary phosphine group —P(R)2; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C1-C4-alkylene skeleton, and in which base skeletons a secondary phosphine group is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group, and in which base skeletons a P-chiral group —P*(O)HR1 is bonded to a carbon atom such that the phosphorus atoms are linked via 1 to 7 atoms of a carbon chain optionally interrupted by heteroatoms from the group of O, S, N, Fe or Si; P* is a chiral phosphorus atom; and R1 is a hydrocarbon radical, a C-bonded heterohydrocarbon radical or a ferrocenyl radical, with the proviso that R1 is an achiral ferrocenyl radical when Q is an achiral ferrocenyl base skeleton. Metal complexes of these ligands in a molar ratio of ligand to metal of about 1.3:1 to 0.9:1 are homogeneous catalysts for asymmetric addition reactions, particularly hydrogenations.

    摘要翻译： 主要以一种对映体或纯对映异构体形式的混合物形式的式I化合物，其中次膦是C键，仲膦基的仲膦-PQ *（= O）HR1（I） P（R）2; 其中R各自独立地为烃基或杂烃基; Q是二价，非手性，芳族碱基骨架，二价，非手性二茂铁碱骨架，任选取代的二价环烷烃或杂环烷骨架，或C 1 -C 4亚烷基骨架，其中碱基骨架的仲膦基直接键合到 碳原子，或者在环状基骨架的情况下，直接与碳原子或C 1 -C 4 - 亚烷基直接键合，并且其中的基础骨架将P手性基团-P *（O）HR1键合到 碳原子，使得磷原子通过1至7个碳链连接，任选被来自O，S，N，Fe或Si基团的杂原子中断; P *是手性磷原子; 并且R 1是烃基，C键合的杂烃基或二茂铁基，条件是当Q是非手性二茂铁基时，R 1是非手性二茂铁基。 配体与金属的摩尔比约为1.3:1至0.9:1的这些配体的金属络合物是用于不对称加成反应，特别是氢化的均相催化剂。

    Method for generating secondary phosphines
    5.
    发明授权
    Method for generating secondary phosphines 有权
    产生次膦的方法

    公开(公告)号：US07256314B2

    公开(公告)日：2007-08-14

    申请号：US11034089

    申请日：2005-01-12

    申请人： Carl Alan Busacca ,  Jon C. Lorenz

    发明人： Carl Alan Busacca ,  Jon C. Lorenz

    IPC分类号： C07F9/02

    CPC分类号： C07F9/5004 ,  C07F9/5018 ,  C07F9/5022 ,  C07F9/509

    摘要： This invention provides a method for generating secondary phosphines from secondary phosphine oxides in the presence of a reducing agent, such as diisobutylaluminum hydride (DIBAL-H), triisobutyldialuminoxane, triisobutylaluminum, tetraisobutyldialuminoxane, or another reducing agent comprising: (i) an R1R2AlH moiety, wherein R1 and R2 are each an alkyl species or oxygen, and wherein at least one of R1 or R2 comprises at least 2 carbon atoms, or (ii) an R1R2R3Al moiety, wherein R1, R2, and R3 are not hydrogen, and wherein at least one of R1, R2, and R3 is an alkyl species comprising a β-hydrogen, not including triethylaluminum. Preferred reducing agents for the present invention include: diisobutylaluminum hydride, triisobutyldialiuminoxane, triisobutylaluminum, tetraisobutyldialuminoxane, and combinations thereof.

    摘要翻译： 本发明提供了一种在还原剂如二异丁基氢化铝（DIBAL-H），三异丁基二铝氧烷，三异丁基铝，四异丁基二铝氧烷或其它还原剂存在下从次膦氧化物产生仲膦的方法，其包括：（i）R 其中R 1和R 2各自为烷基或氧，并且其中至少 R 1或R 2中的一个包含至少2个碳原子，或（ii）R 1 R 2 R 2 其中R 1，R 2和R 3不是氢，并且其中R 1，R 2，R 3和R 3不是氢，并且其中R 1， R 1，R 2和R 3 3中的至少一个是包含不包括三乙基铝的β-氢的烷基物质。 用于本发明的优选的还原剂包括：二异丁基氢化铝，三异丁基二肟氧烷，三异丁基铝，四异丁基二铝氧烷及其组合。

    Phosphine compound, its intermediate, its complex with palladium and a manufacturing method of unsaturated compounds by using the palladium complex
    7.
    发明授权
    Phosphine compound, its intermediate, its complex with palladium and a manufacturing method of unsaturated compounds by using the palladium complex 有权
    膦化合物，其中间体，其与钯的络合物和通过使用钯络合物的不饱和化合物的制备方法

    公开(公告)号：US07129367B2

    公开(公告)日：2006-10-31

    申请号：US10542941

    申请日：2004-02-12

    申请人： Ken Suzuki ,  Yoji Hori

    发明人： Ken Suzuki ,  Yoji Hori

    IPC分类号： C07F15/00 ,  C07F9/02 ,  C07C69/76 ,  C07C45/00 ,  C07C253/00 ,  B01J31/00

    CPC分类号： C07F15/0066 ,  C07B37/04 ,  C07B43/04 ,  C07C17/269 ,  C07C41/30 ,  C07C213/08 ,  C07F9/5018 ,  C07C23/04 ,  C07C217/92 ,  C07C43/205

    摘要： Palladum-phosphine complexes obtained by reacting a 5 compound of formula (1) below with a palladium compound: F(I) (wherein R1 is a hydrogen atom, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R2 and R3 are each, the same or different, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R4 and R5 are each, the same or different, a hydrogen atom, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R6, R7, R8 and R9 are each, the same or different, an alkyl group, a cycloalkyl group, a phenyl group which may be substituted, an alkoxyl group, a dialkylamino group, a halogen atom, a phenyl group, a benzyl group, a naphthyl group or a halogenated alkyl group; R6 and R7, R8 and R9 may be combined to form, each, a fused ring, a trimethylene group, a tetramethylene group or a 20 methylenedioxy group; p, q, r and s are each an integer of 0 to 5; and p+q, and r+s are each in the range of 0 to 5.), which is a novel and efficient catalyst for manufacturing various useful compounds

    摘要翻译： 通过使下述式（1）的化合物与钯化合物F（I）（其中R 1是氢原子，烷基，环烷基或环烷基）反应获得的钯 - 可被取代的苯基; R 2和R 3各自可以相同或不同，可以被取代的烷基，环烷基或苯基; R 4和R 5各自可以相同或不同，可以被取代的氢原子，烷基，环烷基或苯基; R SUP R 6，R 7，R 8和R 9各自各自相同或不同，烷基，环烷基 基团，可被取代的苯基，烷氧基，二烷基氨基，卤原子，苯基，苄基，萘基或卤代烷基; R 6和R 可以将R 8，R 8和R 9组合形成稠环，三亚甲基，四亚甲基g 或二十亚甲二氧基; p，q，r和s各自为0〜5的整数; 和p + q和r + s各自在0至5的范围内），其是用于制备各种有用化合物的新型和有效的催化剂

    Phosphine compound, its intermediate, its complex with palladium and a manufacturing method of unsaturated compounds by using the palladium complex
    8.
    发明申请
    Phosphine compound, its intermediate, its complex with palladium and a manufacturing method of unsaturated compounds by using the palladium complex 有权
    膦化合物，其中间体，其与钯的络合物和通过使用钯络合物的不饱和化合物的制备方法

    公开(公告)号：US20060058542A1

    公开(公告)日：2006-03-16

    申请号：US10542941

    申请日：2004-02-12

    申请人： Ken Suzuki ,  Yoji Hori

    发明人： Ken Suzuki ,  Yoji Hori

    IPC分类号： C07F15/04 ,  C07C51/16 ,  C07F15/00

    CPC分类号： C07F15/0066 ,  C07B37/04 ,  C07B43/04 ,  C07C17/269 ,  C07C41/30 ,  C07C213/08 ,  C07F9/5018 ,  C07C23/04 ,  C07C217/92 ,  C07C43/205

    摘要： Palladum-phosphine complexes obtained by reacting a 5 compound of formula (1) below with a palladium compound: F(I) (wherein R1 is a hydrogen atom, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R2 and R3 are each, the same or different, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R4 and R5 are each, the same or different, a hydrogen atom, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R6, R7, R8 and R9 are each, the same or different, an alkyl group, a cycloalkyl group, a phenyl group which may be substituted, an alkoxyl group, a dialkylamino group, a halogen atom, a phenyl group, a benzyl group, a naphthyl group or a halogenated alkyl group; R6 and R7, R8 and R9 may be combined to form, each, a fused ring, a trimethylene group, a tetramethylene group or a 20 methylenedioxy group; p, q, r and s are each an integer of 0 to 5; and p+q, and r+s are each in the range of 0 to 5.), which is a novel and efficient catalyst for manufacturing various useful compounds.

    摘要翻译： 通过使下述式（1）的化合物与钯化合物F（I）（其中R 1是氢原子，烷基，环烷基或环烷基）反应获得的钯 - 可被取代的苯基; R 2和R 3各自可以相同或不同，可以被取代的烷基，环烷基或苯基; R 4和R 5各自可以相同或不同，可以被取代的氢原子，烷基，环烷基或苯基; R SUP R 6，R 7，R 8和R 9各自各自相同或不同，烷基，环烷基 基团，可被取代的苯基，烷氧基，二烷基氨基，卤原子，苯基，苄基，萘基或卤代烷基; R 6和R 可以将R 8，R 8和R 9组合形成稠环，三亚甲基，四亚甲基g 或二十亚甲二氧基; p，q，r和s各自为0〜5的整数; 和p + q和r + s各自在0至5的范围内），其是用于制备各种有用化合物的新型和有效的催化剂