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公开(公告)号：US09058665B2
公开(公告)日：2015-06-16
申请号：US12650036
申请日：2009-12-30
CPC分类号： G06T7/0012 , A61B6/032 , A61B6/505 , A61B6/508 , A61B6/5241 , G06K9/00 , G06T7/11 , G06T7/13 , G06T7/187 , G06T2207/10081 , G06T2207/20164 , G06T2207/30008
摘要： Systems and method for identifying bone marrow in medical images are provided. A method includes obtaining a three-dimensional (3D) computed tomography (CT) volume data set corresponding to an imaged volume and identifying voxels in the 3D CT volume data set having a Hounsfield Unit (HU) value below a bone threshold. The voxels are identified without using image continuity. The method further includes marking the identified voxels as non-bone voxels, determining definite tissue voxels based on the identified non-bone voxels and expanding a region defined by the definite tissue voxels. The method also includes segmenting the expanded region to identify bone voxels and bone marrow voxels and identifying bone marrow as voxels that are not the bone voxels.
摘要翻译： 提供了用于鉴定医学图像中骨髓的系统和方法。 一种方法包括获得对应于成像体积的三维（3D）计算机断层摄影（CT）体数据集，并且在具有低于骨阈值的Hounsfield单位（HU）值的3D CT体积数据集中识别体素。 识别体素而不使用图像连续性。 该方法还包括将所识别的体素标记为非骨体素，基于所识别的非骨体素来确定确定的组织体素并且扩展由所述确定的组织体素定义的区域。 该方法还包括分割扩大区域以鉴定骨骼体素和骨髓体素，并将骨髓识别为不是骨骼体素的体素。
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2.发明申请ENHANCED RESPONSE OF SOLID STATE PHOTOMULTIPLIER TO SCINTILLATOR LIGHT BY USE OF WAVELENGTH SHIFTERS 审中-公开通过使用波长变换器将固态光电子增强器应用于光栅灯公开(公告)号：US20140061482A1
公开(公告)日：2014-03-06
申请号：US13605082
申请日：2012-09-06
IPC分类号： G01T1/20
CPC分类号： G01T1/2018
摘要： A wavelength shifting material is optically coupled to one of a scintillator and a solid-state photomultiplier and transmits photons along and about a straight linear path. The wavelength shifting material enhances photon sensing performance of the solid state photomultiplier.
摘要翻译： 波长移动材料光学耦合到闪烁体和固态光电倍增管中的一个，并沿着直线路径并且绕直线路径传输光子。 波长转移材料增强了固态光电倍增管的光子感测性能。
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公开(公告)号：US08507869B2
公开(公告)日：2013-08-13
申请号：US13282586
申请日：2011-10-27
IPC分类号： G01T1/166
摘要： Nuclear imaging systems, non-transitory computer readable media and methods for adaptive imaging are presented. Particularly, the present method includes acquiring preliminary projection data by scanning each of one or more views of a subject for a determined preliminary scan interval. Further, a region of interest of the subject is identified. The preliminary projection data is then used to perform a constrained optimization of a rapidly computable image quality metric for determining an acquisition protocol that improves the image quality metric at the identified region of interest. Particularly, the determined acquisition protocol is used to acquire target projection data corresponding to at least the identified region of interest. Further, an image of at least the identified region of interest is reconstructed using the target projection data, the preliminary projection data, or a combination thereof.
摘要翻译： 介绍了核成像系统，非瞬态计算机可读介质和自适应成像方法。 特别地，本方法包括通过扫描被确定的初步扫描间隔的一个或多个视图中的每一个来获取初步投影数据。 此外，识别受试者的感兴趣区域。 然后使用初步投影数据来执行快速可计算的图像质量度量的约束优化，以确定改善所识别的感兴趣区域的图像质量度量的采集协议。 特别地，所确定的获取协议被用于获取对应于至少所识别的感兴趣区域的目标投影数据。 此外，使用目标投影数据，初步投影数据或其组合来重建至少所识别的感兴趣区域的图像。
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公开(公告)号：US20130193330A1
公开(公告)日：2013-08-01
申请号：US13360381
申请日：2012-01-27
CPC分类号： G01T1/1648
摘要： Present embodiments relate to the calibration of detectors having one or more arrays of pixelated detectors. According to an embodiment, a method includes detecting optical outputs generated by a plurality of scintillation crystals of a detector with an array of pixelated detectors, generating, with the array of pixelated detectors, respective signals indicative of the optical outputs, generating, from the respective signals, a unique energy spectrum correlated to each of the plurality of scintillation crystals, grouping subsets of the plurality of scintillation crystals into macrocrystals, determining a representative energy spectrum peak for each macrocrystal based on the respective energy spectra of the scintillation crystals in the macrocrystal, comparing a value of the representative energy spectrum peak for each macrocrystal with a target peak value, and adjusting an operating parameter of at least one pixelated detector in the array of pixelated detectors as a result of the comparison.
摘要翻译： 本实施例涉及具有一个或多个像素化检测器阵列的检测器的校准。 根据实施例，一种方法包括检测由具有像素化检测器阵列的检测器的多个闪烁晶体产生的光输出，利用像素化检测器阵列产生指示光输出的相应信号，从相应的 信号，与多个闪烁晶体中的每一个相关的独特的能量谱，将多个闪烁晶体的子集分组为大的晶体，基于宏晶中的闪烁晶体的各自的能谱确定每个宏晶的代表性能谱峰， 将每个宏晶的代表性能谱峰值与目标峰值进行比较，并且作为比较的结果，调整像素化检测器阵列中的至少一个像素化检测器的操作参数。
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公开(公告)号：US20130136328A1
公开(公告)日：2013-05-30
申请号：US13307753
申请日：2011-11-30
IPC分类号： G06K9/00
CPC分类号： G06T11/005 , G06T2211/436
摘要： Nuclear imaging systems, non-transitory computer readable media and methods for tomographic imaging are presented. Projection data is acquired by scanning one or more views of a subject for a designated scan interval less than a total scan interval. A first image of a target region of interest (ROI) is reconstructed using projection data acquired over a first fraction of the designated scan interval. A second target ROI image is reconstructed using at least a subset of projection data acquired over the first and/or a second fraction. A change in an image quality characteristic over the first and the second fractions is determined by determining one or more differences between the first and the second images. A value of an imaging parameter is estimated based on the change to acquire projection data for generating a target ROI image having at least a predetermined level of the image quality characteristic.
摘要翻译： 提出了核成像系统，非瞬时计算机可读介质和断层成像的方法。 通过扫描对象的指定扫描间隔小于总扫描间隔的一个或多个视图来获取投影数据。 使用在指定的扫描间隔的第一部分获取的投影数据来重建目标感兴趣区域（ROI）的第一图像。 使用在第一和/或第二分数上获取的投影数据的至少一个子集来重建第二目标ROI图像。 通过确定第一和第二图像之间的一个或多个差异来确定第一和第二分数之间的图像质量特性的变化。 基于该变化来估计成像参数的值，以获取用于生成具有图像质量特性的至少预定水平的目标ROI图像的投影数据。
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6.发明授权Method and system for reconstructing an image in a positron emission tomography (PET) system 有权用于在正电子发射断层摄影（PET）系统中重建图像的方法和系统公开(公告)号：US07405405B2
公开(公告)日：2008-07-29
申请号：US11131149
申请日：2005-05-17
申请人： Charles William Stearns , Ravindra Mohan Manjeshwar , Floribertus Philippus Martinus Heukensfeldt Jansen
发明人： Charles William Stearns , Ravindra Mohan Manjeshwar , Floribertus Philippus Martinus Heukensfeldt Jansen
IPC分类号： G01T1/164
CPC分类号： G01T1/2985
摘要： A method and system for reconstructing an image in a time-of-flight (TOF) positron emission tomography (PET) system is provided. The method includes using a reconstructed image to determine predicted timing information. Timing bias data is updated based on received timing information associated with acquired scan data from a PET system and the predicted timing information. The method further includes reconstructing the image, based on the updated timing bias data.
摘要翻译： 提供了一种用于在飞行时间（TOF）正电子发射断层摄影（PET）系统中重建图像的方法和系统。 该方法包括使用重构图像来确定预测的定时信息。 基于与来自PET系统的获取的扫描数据相关联的接收定时信息和预测的定时信息来更新定时偏差数据。 该方法还包括基于更新的定时偏差数据重建图像。
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公开(公告)号：US20080069414A1
公开(公告)日：2008-03-20
申请号：US11531882
申请日：2006-09-14
CPC分类号： G06K9/342 , G06K9/00 , G06K2009/366 , G06K2209/05
摘要： A method and system for segmenting structures such as lesions in an image is provided. The method comprises selecting one seed inside a lesion in an image either by a user or automatically. The method further includes deriving a directionally statistical model based on a background region or a foreground region of the lesion and determining candidate voxels along a radial direction. The candidate voxels represent the lesion. The method further includes segmenting the lesion using the candidate voxels.
摘要翻译： 提供了用于分割诸如图像中的病变的结构的方法和系统。 该方法包括由用户或自动地选择图像中的病变内的一个种子。 该方法还包括基于病变的背景区域或前景区域导出定向统计模型，并沿着径向方向确定候选体素。 候选体素代表病变。 该方法还包括使用候选体素分割病变。
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8.发明授权公开(公告)号：US07227149B2
公开(公告)日：2007-06-05
申请号：US11026236
申请日：2004-12-30
申请人： Charles William Stearns , David Leo McDaniel , John Jay Williams , Alexander Ganin , Ravindra Mohan Manjeshwar , Floribertus Philippus Martinus Heukensfeldt Jansen , Yiping Shao
发明人： Charles William Stearns , David Leo McDaniel , John Jay Williams , Alexander Ganin , Ravindra Mohan Manjeshwar , Floribertus Philippus Martinus Heukensfeldt Jansen , Yiping Shao
IPC分类号： G01T1/164
CPC分类号： G01T1/2985
摘要： Methods and systems for controlling a positron emission tomography (PET) system are provided. The method includes receiving timing information from a PET system during an imaging scan using the PET system. The method further includes processing the received timing information and timing bias information relating to the PET system to control the PET system.
摘要翻译： 提供了用于控制正电子发射断层摄影（PET）系统的方法和系统。 该方法包括在使用PET系统的成像扫描期间从PET系统接收定时信息。 该方法还包括处理接收到的定时信息和与PET系统有关的定时偏差信息以控制PET系统。
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公开(公告)号：US08903152B2
公开(公告)日：2014-12-02
申请号：US13539028
申请日：2012-06-29
申请人： Evren Asma , Ravindra Mohan Manjeshwar , Steven Gerard Ross , Sangtae Ahn , David Erik Chevalier
发明人： Evren Asma , Ravindra Mohan Manjeshwar , Steven Gerard Ross , Sangtae Ahn , David Erik Chevalier
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , G06T2211/424
摘要： Embodiments of methods, systems and non-transitory computer readable media for tomographic imaging are presented. 3D TOF projection data is processed to generate corresponding data in a designated format that allows for computationally cheaper image reconstruction than the 3D TOF projection data. Further, one or more preliminary images are reconstructed from the processed data using a particular image reconstruction technique for one or more iterations. To that end, one or more imaging parameters are iteratively varied every one or more iterations. The imaging parameters, for example, include the designated format, the image reconstruction technique and one or more image quality characteristics. One or more intermediate images are reconstructed from the one or more preliminary images using the iteratively varying imaging parameters. Further, 3D TOF images having the one or more designated image quality characteristics are generated using the one or more intermediate images and the iteratively varying imaging parameters.
摘要翻译： 提出了用于断层成像的方法，系统和非暂时计算机可读介质的实施例。 3D TOF投影数据被处理以产生指定格式的相应数据，这允许比3D TOF投影数据更便宜的图像重建。 此外，使用用于一次或多次迭代的特定图像重建技术，从经处理的数据重建一个或多个预备图像。 为此，每一次或多次迭代迭代地改变一个或多个成像参数。 成像参数例如包括指定格式，图像重建技术和一个或多个图像质量特性。 使用迭代变化的成像参数，从一个或多个初步图像重建一个或多个中间图像。 此外，使用一个或多个中间图像和迭代变化的成像参数来生成具有一个或多个指定图像质量特性的3D TOF图像。
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10.发明申请Method and System for Correction of Lung Density Variation in Positron Emission Tomography Using Magnetic Resonance Imaging 有权使用磁共振成像校正正电子发射断层扫描肺密度变化的方法和系统公开(公告)号：US20140079304A1
公开(公告)日：2014-03-20
申请号：US13618079
申请日：2012-09-14
申请人： Thomas Kwok-Fah Foo , Christopher Judson Hardy , Albert Henry Roger Lonn , Ravindra Mohan Manjeshwar , Dattesh Dayanand Shanbhag , Sheshadri Thiruvenkadam
发明人： Thomas Kwok-Fah Foo , Christopher Judson Hardy , Albert Henry Roger Lonn , Ravindra Mohan Manjeshwar , Dattesh Dayanand Shanbhag , Sheshadri Thiruvenkadam
IPC分类号： G06K9/00
CPC分类号： G06T11/008 , G06T7/11 , G06T7/12 , G06T2207/10088 , G06T2207/10104 , G06T2207/20221 , G06T2207/30061
摘要： Exemplary embodiments of the present disclosure are directed to correcting lung density variations in positron emission tomography (PET) images of a subject using a magnetic resonance (MR) image. A pulmonary vasculature and an outer extent of a lung cavity can be identified in a MR image corresponding to a thoracic region of the subject in response to an intensity associated with pixels in the MR image. The pixels within the outer extent of the lung cavity are classified as corresponding to the pulmonary vasculature or the lung tissue. Exemplary embodiments of the present disclosure can apply attenuation coefficients to a reconstruction of the PET image based on the classification of the pixels within the outer extent of the lung cavity.
摘要翻译： 本公开的示例性实施例涉及使用磁共振（MR）图像校正受试者的正电子发射断层摄影（PET）图像中的肺密度变化。 响应于与MR图像中的像素相关联的强度，可以在对应于受试者的胸部区域的MR图像中识别肺部脉管系统和肺腔的外部范围。 肺腔外部范围内的像素被分类为对应于肺血管或肺组织。 本公开的示例性实施例可以基于肺腔外部范围内的像素的分类，将衰减系数应用于PET图像的重建。
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