公开(公告)号：US5108696A

公开(公告)日：1992-04-28

申请号：US615465

申请日：1990-11-19

申请人： Reinhard Heck

发明人： Reinhard Heck

IPC分类号： G21C9/04 ,  F23Q3/00 ,  G21C9/00 ,  G21C19/30 ,  G21C19/317

CPC分类号： G21C19/317 ,  F23Q3/00

摘要： A device for controlled combustion of an ignitable hydrogen/air mixture in a gas mixture of a nuclear power plant, especially in a containment thereof, includes a spark igniter for tripping an ignition process. At least one ignition source is connected to the spark igniter. The ignition source has a self-sufficient energy storage device. The ignition source has at least one first trip element connected between the spark igniter and the energy storage device for responding as a function of temperature to trip the ignition process, and at least one second trip element connected between the spark igniter and the energy storage device for responding as a function of pressure to trip the ignition process. The at least one first trip element is in thermally conductive contact and the at least one second trip element is in pressure-transmitting contact with the gas mixture to be monitored. The energy storage device discharges to the spark igniter if one of the trip elements responds. The spark igniter creates ignition sparks being repeated at intervals during an accident extending over a relatively long period of time.

摘要翻译： 用于核燃料发电厂的气体混合物中的可点燃的氢/空气混合物的受控燃烧的装置，特别是在其封闭物中，包括用于跳闸点火过程的火花点火器。 至少一个点火源连接到火花点火器。 点火源具有自给自足的储能装置。 点火源具有连接在火花点火器和能量存储装置之间的至少一个第一跳闸元件，用于响应于温度的函数以跳闸点火过程，以及连接在火花点火器和能量存储装置之间的至少一个第二跳闸元件 作为压力的函数来响应点火过程。 所述至少一个第一跳闸元件是导热接触的，并且所述至少一个第二跳闸元件与待监控的气体混合物进行压力传递接触。 如果其中一个跳闸元件响应，则能量存储装置将放电到火花点火器。 火花点火器在相当长的一段时间内的事故期间间歇地产生点火火花。

公开(公告)号：US4970077A

公开(公告)日：1990-11-13

申请号：US358792

申请日：1989-06-01

申请人： Bruno Dreckmann ,  Reinhard Heck ,  Johannes Pill

发明人： Bruno Dreckmann ,  Reinhard Heck ,  Johannes Pill

IPC分类号： A61K31/19 ,  A61K31/365 ,  A61K31/366 ,  A61P3/06 ,  A61P9/10 ,  C07C45/44 ,  C07C45/51 ,  C07C45/56 ,  C07C45/62 ,  C07C59/48 ,  C07C65/21 ,  C07C69/732 ,  C07C235/34 ,  C07D309/30

CPC分类号： C07D309/30 ,  C07C45/44 ,  C07C45/516 ,  C07C45/56 ,  C07C45/62 ,  C07C65/21 ,  C07C2101/14 ,  C07C2101/16 ,  C07C2101/18

摘要： The present invention provides compounds of the general formula: ##STR1## wherein E is an alkylene or alkenylene radical containing 2 carbon atoms, R.sup.1 is a cycloaliphatic hydrocarbon radical containing 5 to 12 carbon atoms, which is optionally substituted by up to 4 lower alkyl radicals, as well as halogen atoms, and can optionally be mono- or polyunsaturated, R.sup.2 and R.sup.3, which can be the same or different, are further cycloaliphatic hydrocarbon radicals containing 3 to 7 carbon atoms, hydrogen or halogen atoms, trifluoromethyl radicals or alkyl or alkoxy radicals containing up to 7 carbon atoms which can optionally also be substituted with methyl radicals, X is hydroxyl, Y is a residue of an alcohol or a residue of an amine or the group OZ, Z is hydrogen, an alkali metal or ammonium ion or X and Y taken together are --O--. Thus, these compounds are lactones or hydroxy acids of the formulae: ##STR2## wherein E, R.sup.1, R.sup.2 and R.sup.3 are as stated above, and Z is a hydrogen atom, and alkali metal ion or an ammonium ion; the esters and amides of the free carboxylic acids and the stereoisomeric forms thereof.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.

摘要翻译： 本发明提供以下通式的化合物：其中E为含有2个碳原子的亚烷基或亚烯基，R 1为含有5至12个碳原子的脂环族烃基，其任选被至多4个低级烷基取代 ，以及卤原子，并且可以任选地是单或多不饱和的，可以相同或不同的R 2和R 3是进一步含有3-7个碳原子的脂环族烃基，氢或卤原子，三氟甲基或烷基或 含有至多7个碳原子的烷氧基，其也可任选地被甲基取代，X是羟基，Y是醇的残基或胺的残基或OZ，Z是氢，碱金属或铵离子 或X和Y一起为-O-。 因此，这些化合物是下式的内酯或羟基酸：其中E，R1，R2和R3如上所述，Z是氢原子，碱金属离子或铵离子; 游离羧酸的酯和酰胺及其立体异构形式。 本发明还提供了制备这些化合物的方法和含有它们的药物组合物。

公开(公告)号：US5473646A

公开(公告)日：1995-12-05

申请号：US219784

申请日：1994-03-30

申请人： Reinhard Heck ,  Karl-Heinz Schwenk

发明人： Reinhard Heck ,  Karl-Heinz Schwenk

IPC分类号： B01J23/42 ,  B01D53/22 ,  B01J8/04 ,  B01J12/00 ,  B01J23/44 ,  B01J35/04 ,  C01B3/54 ,  C01B5/00 ,  G21C9/04 ,  G21C9/06 ,  G21C19/303 ,  G21C19/317 ,  G21F9/02

CPC分类号： C01B5/00 ,  B01J12/007 ,  G21C19/317 ,  G21C9/06 ,  Y02E30/40

摘要： A device for the recombination of hydrogen and oxygen includes catalyst bodies having surfaces and a catalytic coating on the surfaces over which a gas and vapor mixture containing hydrogen to be eliminated is to be conducted. A casing which surrounds and retains the catalyst bodies has at least one permanently open gas inlet aperture and one permanently open gas outlet aperture, and a gas flow path in the casing through which the apertures communicate. The catalyst bodies are disposed downstream of the gas inlet aperture in the gas flow path. The catalyst bodies are flat bodies formed of multi-layered sheet metal in a multi-channel configuration forming a plurality of mutually parallel gas flow channels. Some of the gas flow channels have channel cross sections being defined by at least an adjacent two of the flat bodies being spaced-apart, and the gas flow channels at ends of the configuration have channel cross sections being defined by at least one of the flat bodies. The flat bodies each have a metal support sheet, a porous adhesion-promoting surface structure of the support sheet with a thickness of less than 10 .mu.m, a porous intermediate layer, preferably of Al.sub.2 O.sub. 3, applied to the surface structure for increasing surface area, and a catalyst coating of platinum or palladium being applied to the intermediate layer and distributed finely enough to preserve porosity of the intermediate layer.

摘要翻译： 用于氢和氧的重组的装置包括在表面上具有表面的催化剂体和在其上要进行包含要消除的氢的气体和蒸气混合物的表面。 围绕并保持催化剂体的壳体具有至少一个永久开放的气体入口孔和一个永久开放的气体出口孔，以及孔中通气孔的气体流路。 催化剂体设置在气体流路中的气体入口孔的下游。 催化剂体是多层金属板形成的平坦体，多层结构形成多个相互平行的气流通道。 一些气体流动通道具有通道横截面，该通道横截面由至少相邻的两个平坦体间隔开限定，并且构造端部处的气体流动通道具有通道横截面，该通道横截面由至少一个平面 身体。 扁平体各自具有金属支撑片，厚度小于10μm的支撑片的多孔粘合促进表面结构，施加到用于增加表面积的表面结构的多孔中间层，优选为Al 2 O 3 ，并且将铂或钯的催化剂涂层施加到中间层并且分布得足够细，以保持中间层的孔隙率。

公开(公告)号：US5301217A

公开(公告)日：1994-04-05

申请号：US975528

申请日：1992-11-12

申请人： Reinhard Heck ,  Karl-Heinz Schwenk

发明人： Reinhard Heck ,  Karl-Heinz Schwenk

IPC分类号： B01J23/42 ,  B01D53/22 ,  B01J8/04 ,  B01J12/00 ,  B01J23/44 ,  B01J35/04 ,  C01B3/54 ,  C01B5/00 ,  G21C9/04 ,  G21C9/06 ,  G21C19/303 ,  G21C19/317 ,  G21F9/02

CPC分类号： C01B5/00 ,  B01J12/007 ,  G21C19/317 ,  G21C9/06 ,  Y02E30/40

摘要： A device for the recombination of hydrogen and oxygen includes catalyst bodies having surfaces and a catalytic coating on the surfaces over which a gas and vapor mixture containing hydrogen to be eliminated is to be conducted. A casing which surrounds and retains the catalyst bodies has at least one permanently open gas inlet aperture and one permanently open gas outlet aperture, and a gas flow path in the casing through which the apertures communicate. The catalyst bodies are disposed downstream of the gas inlet aperture in the gas flow path. The catalyst bodies are flat bodies formed of multi-layered sheet metal in a multi-channel configuration forming a plurality of mutually parallel gas flow channels. Some of the gas flow channels have channel cross sections being defined by at least an adjacent two of the flat bodies being spaced-apart, and the gas flow channels at ends of the configuration have channel cross sections being defined by at least one of the flat bodies. The flat bodies each have a metal support sheet, a porous adhesion-promoting surface structure of the support sheet with a thickness of less than 10 .mu.m, a porous intermediate layer, preferably of Al.sub. O.sub. 3, applied to the surface structure for increasing surface area, and a catalyst coating of platinum or palladium being applied to the intermediate layer and distributed finely enough to preserve porosity of the intermediate layer.

摘要翻译： 用于氢和氧的重组的装置包括在表面上具有表面的催化剂体和在其上要进行包含要消除的氢的气体和蒸气混合物的表面。 围绕并保持催化剂体的壳体具有至少一个永久开放的气体入口孔和一个永久开放的气体出口孔，以及孔中通气孔的气体流路。 催化剂体设置在气体流路中的气体入口孔的下游。 催化剂体是多层金属板形成的平坦体，多层结构形成多个相互平行的气流通道。 一些气体流动通道具有通道横截面，该通道横截面由至少相邻的两个平坦体间隔开限定，并且构造端部处的气体流动通道具有通道横截面，该通道横截面由至少一个平面 身体。 扁平体各自具有金属支撑片，厚度小于10（my）m的支撑片的多孔粘附促进表面结构，优选为AlO 3的多孔中间层，施加到表面结构以增加 表面积和铂或钯的催化剂涂层施加到中间层并且分布得足够细，以保持中间层的孔隙率。

公开(公告)号：US4911879A

公开(公告)日：1990-03-27

申请号：US232316

申请日：1988-08-15

申请人： Reinhard Heck ,  Willi Siegler ,  Klaus-Dieter Werner

发明人： Reinhard Heck ,  Willi Siegler ,  Klaus-Dieter Werner

IPC分类号： B01J35/04 ,  B01J12/00 ,  C01B5/00 ,  F23Q11/00 ,  G21C9/00 ,  G21C19/30 ,  G21C19/317 ,  G21F9/00 ,  G21F9/02

CPC分类号： F23Q11/00 ,  C01B5/00 ,  G21C19/317

摘要： An apparatus for the recombination of hydrogen and oxygen with the aid of a catalyst includes a vertically extending tube having end surfaces. A catalyst body is disposed in the tube. Stoppers close the end surfaces of the tube and open as a function of at least one parameter from the group consisting of pressure and temperature.

摘要翻译： 借助于催化剂重组氢和氧的装置包括具有端表面的垂直延伸的管。 催化剂体设置在管中。 止动器关闭管的端面并作为来自由压力和温度组成的组中的至少一个参数的函数打开。

公开(公告)号：US4891181A

公开(公告)日：1990-01-02

申请号：US191274

申请日：1988-05-06

申请人： Reinhard Heck

发明人： Reinhard Heck

IPC分类号： G21D3/08 ,  F23Q3/00 ,  G21C19/317

CPC分类号： G21C19/317 ,  F23Q3/00

摘要： An apparatus for the controlled combustion of ignitable hydrogen-air mixtures in the containment of water-cooled nuclear reactor plants includes at least one ignition source having a self-sufficient energy reservoir with a charge status being monitorable at regular time intervals. A tripping element of the ignition source responds as a function of temperature for tripping an ignition process and triggering a discharge of the energy reservoir in the ignition source during a predetermined period of time.

摘要翻译： 在水冷式核反应堆装置的容纳物中可燃燃烧氢气 - 空气混合物的装置包括至少一个具有自给能量储能器的点火源，其充电状态可以以规则的时间间隔监视。 点火源的跳闸元件响应于温度的函数，用于跳闸点火过程并且在预定时间段期间触发点火源中的能量储存器的排放。

公开(公告)号：US5795892A

公开(公告)日：1998-08-18

申请号：US793445

申请日：1997-02-28

申请人： Wolfgang Von Der Saal ,  Reinhard Heck ,  Ralf Kucznierz ,  Herbert Leinert ,  Karlheinz Stegmeier

发明人： Wolfgang Von Der Saal ,  Reinhard Heck ,  Ralf Kucznierz ,  Herbert Leinert ,  Karlheinz Stegmeier

IPC分类号： A61K31/50 ,  A61P7/02 ,  C07D237/20 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D237/22

CPC分类号： C07D401/12 ,  C07D237/20 ,  C07D405/12 ,  C07D409/12

摘要： The invention concerns new 4-aminopyridazines of the general formula I ##STR1## in which R.sup.1 denotes an R.sup.2 --SO.sub.2 --O-- or R.sup.2 --SO.sub.2 --NR.sup.3 -- group in which R.sup.2 denotes a cycloalkyl residue, an unsubstituted or substituted aryl or heteroaryl residue, R.sup.3 denotes a hydrogen atom, an alkyl or alkyloxyalkyl group which can be unsubstituted or substituted once or several times by hydroxy groups wherein the hydroxy groups can be substituted by alkyl, hydroxyalkyl, alkyloxyalkyl, hydroxyalkyloxyalkyl or alkylcarbonyl groups and wherein in each case two vicinal hydroxy groups can be linked together by alkylidene groups, as well as hydrates, solvates and physiologically tolerated salts thereof. The invention also concerns the optically active forms, racemates and mixtures of diastereomers of these compounds, processes for their production and pharmaceutical agents containing these compounds having a thrombin-inhibiting action.

摘要翻译： PCT No.PCT / EP95 / 03383 Sec。 371日期1997年2月28日 102（e）日期1997年2月28日PCT 1995年8月26日PCT PCT。 公开号WO96 / 06832 日期1996年3月7日本发明涉及通式Ⅰ（I）的新的4-氨基哒嗪，其中R1表示R2-SO2-O-或R2-SO2-NR3-基团，其中R2表示环烷基残基， 未取代或取代的芳基或杂芳基残基，R3表示氢原子，烷基或烷氧基烷基，其可以是未取代的或被羟基取代一次或几次，其中羟基可以被烷基，羟烷基，烷氧基烷基，羟基烷氧基烷基或烷基羰基 基团，并且其中在每种情况下，两个邻位羟基可以通过亚烷基连接在一起，以及其水合物，溶剂化物和生理上耐受的盐。 本发明还涉及这些化合物的光学活性形式，外消旋物和非对映异构体的混合物，其制备方法和含有这些具有凝血酶抑制作用的化合物的药剂。

公开(公告)号：US06452001B2

公开(公告)日：2002-09-17

申请号：US09854885

申请日：2001-05-14

申请人： Guido Galley ,  Annick Goergler ,  Thierry Godel ,  Reinhard Heck

发明人： Guido Galley ,  Annick Goergler ,  Thierry Godel ,  Reinhard Heck

IPC分类号： C07D24300

CPC分类号： C07D401/06 ,  C07D243/14 ,  C07D403/06 ,  C07D409/06 ,  C07D487/04

摘要： The invention relates to compounds of the formula wherein R1, R2 are independently from each other aryl or heteroaryl, wherein the heteroaryl group contains one or two heteroatoms, selected from N, O, or S, and wherein the aryl or heteroaryl groups are optionally substituted by 1 to 3 substituents, which are independently from each other halogen, CF3, lower alkoxy or lower alkyl; R3 is hydrogen, lower alkyl, —(CH2)nN(R)2, —(CH2)n-heteroaryl or is a —(CH2)n-non aromatic heterocycle, which heterocycles are optionally substituted by halogen, CF3, lower alkoxy or lower alkyl; R4 is ═O, ═N(CH2)nCH3 or ═N(CH2)nN(R)2; R3 and R4 may be together with the N and C atoms to which they are attached the group —CR5═N—N═; R5 is hydrogen, —(CH2)nN(R)2, —(CH2)n-heteroaryl or is a —(CH2)n-non aromatic heterocycle, which heterocycles are optionally substituted by halogen, CF3, lower alkoxy or lower alkyl; R is hydrogen or lower alkyl; n is 0, 1, 2 or 3; and pharmaceutically acceptable acid addition salts and enantiomeric forms thereof. The compounds are useful in the treatment of diseases, related to the NK-1 receptor.

摘要翻译： 本发明涉及式I的化合物，R 2彼此独立地为芳基或杂芳基，其中杂芳基含有一个或两个选自N，O或S的杂原子，其中芳基或杂芳基任选被1 3个取代基，它们彼此独立地为卤素，CF 3，低级烷氧基或低级烷基; R 3为氢，低级烷基， - （CH 2）n N（R）2， - （CH 2）n - 杂芳基或为 - （CH 2 ）杂环任选被卤素，CF 3，低级烷氧基或低级烷基取代; R 4是= O，= N（CH 2）n CH 3或= N（CH 2）n N（R）2; R 3和R 4可以 与它们所连接的N和C原子一起是-CR5 = NN =; R 5是氢， - （CH 2）n N（R）2， - （CH 2）n - 杂芳基或是 - （CH 2）n - 非芳族杂环，所述杂环任选被卤素，CF 3，低级烷氧基或低级烷基取代; R为氢或低级烷基; n为0,1,2或3;及其药学上可接受的酸加成盐及其对映体形式。 该化合物可用于治疗与NK-1受体有关的疾病。

公开(公告)号：US4631164A

公开(公告)日：1986-12-23

申请号：US708372

申请日：1985-03-06

申请人： Reinhard Heck

发明人： Reinhard Heck

IPC分类号： G21C9/00 ,  G21C13/00 ,  G21C13/02 ,  G21C19/317 ,  G21D3/08 ,  G21F9/00 ,  G21F9/02

CPC分类号： G21C19/317 ,  G21C13/022 ,  G21C9/00 ,  Y02E30/40

摘要： Nuclear power station, including a containment for enclosing activity-carrying components having a given height and upper and lower parts, pipelines being extended in vertical direction in the containment over at least half of the given height thereof from the upper part to the lower part of the containment for mixing a gas atmosphere in the containment, the pipelines having an open top and bottom and an outlet in the lower part of the containment, a transporting device for mixing the gas atmosphere in the containment in the form of a blower connected in the pipelines for transporting gas from the upper part to the lower part of the containment in the pipelines, and a recombination device connected downstream of the blower in the pipelines for shunting the outlets thereof in the lower part and for targeted oxidation of free hydrogen within the containment.

摘要翻译： 核电站，包括用于封闭具有给定高度的活动承载部件和上部和下部的容纳物，管道在容纳物中沿垂直方向在其至少一半给定高度上从上部到下部延伸 用于将气体气体混合在容纳物中的容纳物，具有开口顶部和底部的管道以及容纳物的下部中的出口，用于将气体气氛混合在容纳件中的鼓风机形式的输送装置， 用于将气体从管道中的容器的上部输送到下部的管道，以及连接在管道中的鼓风机下游的重组装置，用于将其下部的出口分流并用于目标氧化遏制物内的游离氢 。