公开(公告)号：US20090221595A1

公开(公告)日：2009-09-03

申请号：US12313975

申请日：2008-11-25

Applicant: Nurit Perlman ,  Revital Ramaty ,  Eli Lancry ,  Marina Kalujny

Inventor： Nurit Perlman ,  Revital Ramaty ,  Eli Lancry ,  Marina Kalujny

IPC: A61K31/4985 ,  C07D471/04 ,  A61P3/10

CPC classification number: C07D487/04

Abstract: A Sitagliptin crystalline form characterized by PXRD pattern having any 5 peaks selected from the group consisting of 7.4, 11.5, 16.7, 17.7, 18.9, 24.1, 24.5, 27.0, 28.5 and 28.8±0.2 degrees 2-theta, wherein any combination of peaks selected includes the peak at 7.4±0.2 degrees two theta, processes for preparing said Sitagliptin crystalline form, and pharmaceutical compositions thereof, are provided.

Abstract translation: 西他列汀结晶形式，其特征在于具有选自7.4,11.5,16.7,17.7,18.9,24.1,24.5,27.0,28.5和28.8±0.2度2-θ的任何5个峰的PXRD图，其中所选择的峰的任意组合 包括峰值在7.4±0.2度2θ，制备所述西格列汀结晶形式的方法及其药物组合物。

公开(公告)号：US20070060645A1

公开(公告)日：2007-03-15

申请号：US11440246

申请日：2006-05-23

Applicant: Revital Lifshitz-Liron ,  Yuriy Raizi ,  Revital Ramaty

Inventor： Revital Lifshitz-Liron ,  Yuriy Raizi ,  Revital Ramaty

IPC: A61K31/325 ,  A61K31/137 ,  C07C271/30 ,  G01N33/50

CPC classification number: C07C209/84 ,  C07C209/90 ,  C07C271/12 ,  C07C211/30 ,  C07C211/63

Abstract: Isolated cinacalcet carbamate, processes for the preparation thereof, and processes for the use of cinacalcet carbamate as a reference marker and standard are provided. Also provided are cinacalcet salts substantially free of cinacalcet carbamate, and processes for the preparation thereof.

Abstract translation: 提供了分离的西那卡塞氨基甲酸酯，其制备方法，以及使用西那卡塞氨基甲酸酯作为参考标记和标准的方法。 还提供了基本上不含西那卡塞氨基甲酸酯的西那卡塞盐及其制备方法。

公开(公告)号：US20100249140A1

公开(公告)日：2010-09-30

申请号：US12749486

申请日：2010-03-29

Applicant: Gideon PILARSKI ,  Nurit PERLMAN ,  Ariel MITTELMAN ,  Nada KOSUTIC HULITA ,  Marina KALUJNY ,  Revital RAMATY

Inventor： Gideon PILARSKI ,  Nurit PERLMAN ,  Ariel MITTELMAN ,  Nada KOSUTIC HULITA ,  Marina KALUJNY ,  Revital RAMATY

IPC: A61K31/4985 ,  C07D487/04 ,  A61P3/10

CPC classification number: C07D487/04

Abstract: Solid state forms of Sitagliptin salts, processes for preparing the solid state forms, and pharmaceutical compositions thereof, are provided.

Abstract translation: 提供西他列汀盐的固体形式，制备固态形式的方法及其药物组合物。

公开(公告)号：US20070043243A1

公开(公告)日：2007-02-22

申请号：US11435430

申请日：2006-05-16

Applicant: Revital Lifshitz-Liron ,  Amihai Eisenstadt ,  Shlomit Wizel ,  Sharon Avhar-Maydan ,  Yuriy Raizi ,  Revital Ramaty

Inventor： Revital Lifshitz-Liron ,  Amihai Eisenstadt ,  Shlomit Wizel ,  Sharon Avhar-Maydan ,  Yuriy Raizi ,  Revital Ramaty

IPC: C07C211/27

CPC classification number: C07C209/08 ,  C07B2200/07 ,  C07C209/16 ,  C07C209/22 ,  C07C211/30

Abstract: Processes for preparing cinacalcet are provided.

Abstract translation: 提供了制备西那卡塞的方法。

公开(公告)号：US20120316175A1

公开(公告)日：2012-12-13

申请号：US13589893

申请日：2012-08-20

Applicant: Gideon PILARSKI ,  Nurit PERLMAN ,  Ariel MITTELMAN ,  Nada KOSUTIC HULITA ,  Marina KALUJNY ,  Revital RAMATY

Inventor： Gideon PILARSKI ,  Nurit PERLMAN ,  Ariel MITTELMAN ,  Nada KOSUTIC HULITA ,  Marina KALUJNY ,  Revital RAMATY

IPC: C07D487/04 ,  A61P3/10 ,  A61K31/4985

CPC classification number: C07D487/04

Abstract: Solid state forms of Sitagliptin salts, processes for preparing the solid state forms, and pharmaceutical compositions thereof, are provided.

Abstract translation: 提供西他列汀盐的固体形式，制备固态形式的方法及其药物组合物。

公开(公告)号：US20100041885A1

公开(公告)日：2010-02-18

申请号：US12410738

申请日：2009-03-25

Applicant: Nurit Perlman ,  Revital Ramaty ,  Mili Abramov ,  Nina Finkelstein ,  Eli Lancry ,  Shay Asis ,  Ariel Mittelman

Inventor： Nurit Perlman ,  Revital Ramaty ,  Mili Abramov ,  Nina Finkelstein ,  Eli Lancry ,  Shay Asis ,  Ariel Mittelman

IPC: C07D471/08

CPC classification number: C07D487/04

Abstract: A Sitagliptin phosphate characterized by data selected from the group consisting of: a powder XRD pattern with peaks at 4.7, 13.5, 17.7, 18.3, and 23.7±0.2 degrees two theta; a powder XRD pattern with peaks at about 4.7, 13.5, and 15.5±0.2 degrees two theta and at least another two peaks selected from the following list: 14.0, 14.4, 18.3, 19.2, 19.5 and 23.7±0.2 degrees two theta; and a powder XRD pattern with peaks at about 13.5, 19.2, and 19.5±0.2 degrees two theta and at least another two peaks selected from the following list: 4.7, 14.0, 15.1, 15.5, 18.3, and 18.7±0.2 degrees two theta; a powder XRD pattern with peaks at about 13.5, 15.5, 19.2, 23.7, and 24.4±0.2 degrees two theta; and a powder XRD pattern with peaks at about 4.65, 13.46, 17.63, 18.30, and 23.66±0.10 degrees two theta, processes for preparing said Sitagliptin crystalline form, and pharmaceutical compositions thereof, are provided.

Abstract translation: 磷酸西他列汀，其特征在于选自以下的数据：粉末XRD图谱，其峰为4.7,13.5,17.7,18.3和23.7±0.2度2θ; 在约4.7,13.5和15.5±0.2度2θ处具有峰的粉末XRD图案和至少另外两个选自以下列表的峰：14.0,14.4,18.3,19.2,19.5和23.7±0.2度2θ; 和具有在约13.5,19.2和19.5±0.2度2θ处以及从下列列表中选择的至少另外两个峰的峰的粉末XRD图：4.7,14.0,15.1,15.5,18.3和18.7±0.2度2θ; 在约13.5,15.5,19.2,23.7和24.4±0.2度2θ处具有峰的粉末XRD图案; 并且提供了在约4.65,13.46,17.63,18.30和23.66±0.10度2θ处具有峰的粉末XRD图案，制备所述西格列汀结晶形式的方法及其药物组合物。

公开(公告)号：US07250533B2

公开(公告)日：2007-07-31

申请号：US11435430

申请日：2006-05-16

Applicant: Revital Lifshitz-Liron ,  Amihai Eisenstadt ,  Shlomit Wizel ,  Sharon Avhar-Maydan ,  Yuriy Raizi ,  Revital Ramaty

Inventor： Revital Lifshitz-Liron ,  Amihai Eisenstadt ,  Shlomit Wizel ,  Sharon Avhar-Maydan ,  Yuriy Raizi ,  Revital Ramaty

IPC: C07C211/00

CPC classification number: C07C209/08 ,  C07B2200/07 ,  C07C209/16 ,  C07C209/22 ,  C07C211/30

Abstract: Processes for preparing cinacalcet are provided.

公开(公告)号：US20060252932A1

公开(公告)日：2006-11-09

申请号：US11361509

申请日：2006-02-24

Applicant: Tamar Nidam ,  Viviana Braude ,  Miri Adler ,  Revital Ramaty

Inventor： Tamar Nidam ,  Viviana Braude ,  Miri Adler ,  Revital Ramaty

IPC: C07D413/14

CPC classification number: C07D263/20 ,  A61K31/5377 ,  C07D413/10 ,  C07D413/14

Abstract: The present invention provides an isolated linezolid (1) impurity, bis-linezolid (4), preparation thereof and its use as a reference standard.

Abstract translation: 本发明提供了一种分离的利奈唑胺（1）杂质，双利奈唑胺（4），其制备方法及其用途作为参考标准。

公开(公告)号：US08329696B2

公开(公告)日：2012-12-11

申请号：US12749486

申请日：2010-03-29

Applicant: Gideon Pilarski ,  Nurit Perlman ,  Ariel Mittelman ,  Nada Kosutic Hulita ,  Marina Kalujny ,  Revital Ramaty

Inventor： Gideon Pilarski ,  Nurit Perlman ,  Ariel Mittelman ,  Nada Kosutic Hulita ,  Marina Kalujny ,  Revital Ramaty

IPC: A61K31/495

CPC classification number: C07D487/04

Abstract: Solid state forms of Sitagliptin salts (e.g. Sitagliptin sulfate, Formula I), processes for preparing the solid state forms, and pharmaceutical compositions thereof, are provided. These compounds are of a class of dipeptidyl peptidase IV enzyme inhibitors which are useful, for example, for the manufacture of a medicament for the treatment of type 2 diabetes mellitus.

Abstract translation: 提供西他列汀盐（例如硫酸西替他嗪，式I）的固体形式，制备固体形式的方法及其药物组合物。 这些化合物是一类二肽基肽酶IV酶抑制剂，其可用于例如制备用于治疗2型糖尿病的药物。

公开(公告)号：US20080287447A1

公开(公告)日：2008-11-20

申请号：US12012422

申请日：2008-01-31

Applicant: Nina Finkelstein ,  Marioara Mendelovici ,  Revital Ramaty ,  Alex Mainfeld

Inventor： Nina Finkelstein ,  Marioara Mendelovici ,  Revital Ramaty ,  Alex Mainfeld

IPC: A61K31/4985 ,  C07D471/04 ,  A61P25/20

CPC classification number: C07D401/14

Abstract: Methods for the preparation of crystalline eszopiclone free base in water, in the absence of organic solvents, are provided. The methods are more environmentally acceptable than prior art methods, and produce eszopiclone free base essentially free of residual organic solvent.

Abstract translation: 提供了在不存在有机溶剂的情况下在水中制备结晶埃佐普隆游离碱的方法。 这些方法比现有技术的方法更环保可接受，并且产生基本上不含残余有机溶剂的不含佐佐匹克隆的碱。