公开(公告)号：US5340579A

公开(公告)日：1994-08-23

申请号：US541119

申请日：1990-06-20

申请人： Riccardo Casero, deceased

发明人： Riccardo Casero, deceased

IPC分类号： A61K8/73 ,  A61K8/98 ,  A61Q7/00 ,  A61K35/00 ,  A61K37/00 ,  A61K37/02 ,  A61K37/10

CPC分类号： A61K8/735 ,  A61K8/982 ,  A61Q7/00 ,  Y10S514/844 ,  Y10S514/847 ,  Y10S514/858 ,  Y10S514/859 ,  Y10S514/86 ,  Y10S514/861 ,  Y10S514/862 ,  Y10S514/863 ,  Y10S514/864 ,  Y10S514/865

摘要： A method is provided for treating dermatological conditions by binding and blocking 5-a-dihydrotestosterone receptors comprising applying to the skin an effective amount of composition comprising:(a) from about 0.1% to about 2.0% by weight of mucopolysaccharides free of proteins and having a pH ranging from about 5 to 7.5 in aqueous solution, a rotary power between about to +15, and a sulfur content greater than 6%;(b) from about 1% to about 3% by weight of an aqueous extract of human umbilical cord free from sulfur and having a DH of from about 5 to about 7, a viscosity of 30.degree. C. of from 10 to 25 centistokes, a hyaluronic acid titre of from about 500 to about 700 mg/dl, and an ash content of less than about 0.5%;(c) from about 0.05 to about 0.08% by weight of tetrahydrofurfuryl nicotinate; and(d) pharmaceutically and cosmetically acceptable vehicles and excipients.This method is particularly useful in treating dermatological conditions such as acne, wrinkles, lipodiystrophies, dermosclorosis, androgenic alopecia, hypertrichosis, and the like.

摘要翻译： 提供了通过结合和阻断5-α-二氢睾酮受体来治疗皮肤病学病症的方法，包括向皮肤施用有效量的组合物，其包含：（a）约0.1％至约2.0％重量的不含蛋白质的粘多糖， 在水溶液中约5至7.5的pH，约+15之间的旋转动力和大于6％的硫含量; （b）约1％至约3％重量的不含硫的人脐带水提取物，其DH为约5至约7，粘度为30至10厘沲， 约500至约700mg / dl的透明质酸滴度和小于约0.5％的灰分含量; （c）约0.05至约0.08重量％的四氢糠基烟酸酯; 和（d）药学上和化妆品上可接受的载体和赋形剂。 该方法特别可用于治疗皮肤病，如痤疮，皱纹，脂肪营养不良，皮肤病，雄激素性脱发，肥大症等。