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公开(公告)号：US07393681B2
公开(公告)日：2008-07-01
申请号：US11130884
申请日：2005-05-17
IPC分类号： C12M1/42
CPC分类号： C12M35/02 , A61K48/00 , C12M23/28 , C12M45/07 , C12N15/86 , C12N2710/16632 , C12N2710/16643 , C12N2830/00 , C12N2830/008
摘要： A system and method are described for electroporating a sample that utilizes one or more sets of electrodes that are spaced apart in order to hold a surface tension constrained sample between the electrodes. The first electrode is connected to the lower body of the system while the second electrode is connected to the upper body. Both electrodes are connected to a pulse generator. Each electrode has a sample contact surface such that the first electrode and the second electrode may be positioned to hold a surface tension constrained sample between the two sample contact surfaces and the sample may receive a selected electric pulse.
摘要翻译： 描述了一种用于电穿孔样品的系统和方法，该样品利用间隔开的一组或多组电极，以便在电极之间保持表面张力约束的样品。 第一电极连接到系统的下体，而第二电极连接到上身。 两个电极连接到脉冲发生器。 每个电极具有样品接触表面，使得第一电极和第二电极可以被定位成在两个样品接触表面之间保持表面张力约束的样品，并且样品可以接收所选择的电脉冲。
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公开(公告)号：US06897069B1
公开(公告)日：2005-05-24
申请号：US10863102
申请日：2004-06-08
IPC分类号： A61K35/76 , A61K38/44 , A61K48/00 , C12N15/869 , C12N15/87
CPC分类号： C12M35/02 , A61K48/00 , C12M23/28 , C12M45/07 , C12N15/86 , C12N2710/16632 , C12N2710/16643 , C12N2830/00 , C12N2830/008
摘要： A system and method are described for electroporating a sample that utilizes one or more sets of electrodes that are spaced apart in order to hold a surface tension constrained sample between the electrodes. The first electrode is connected to the lower body of the system while the second electrode is connected to the upper body. Both electrodes are connected to a pulse generator. Each electrode has a sample contact surface such that the first electrode and the second electrode may be positioned to hold a surface tension constrained sample between the two sample contact surfaces and the sample may receive a selected electric pulse.
摘要翻译： 描述了一种用于电穿孔样品的系统和方法，该样品利用间隔开的一组或多组电极，以便在电极之间保持表面张力约束的样品。 第一电极连接到系统的下体，而第二电极连接到上身。 两个电极连接到脉冲发生器。 每个电极具有样品接触表面，使得第一电极和第二电极可以被定位成在两个样品接触表面之间保持表面张力约束的样品，并且样品可以接收所选择的电脉冲。
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3.发明申请公开(公告)号：US20180126382A1
公开(公告)日：2018-05-10
申请号：US15784604
申请日：2017-10-16
申请人： Richard A. Jarvis
发明人： Richard A. Jarvis
CPC分类号： B01L7/02 , B01L9/06 , B01L2200/141 , B01L2200/147 , B01L2300/12 , B01L2300/1805 , C09K5/14
摘要： Systems and methods for controlling the temperature of items such as a sample in a vessel or a specimen, in a thermal bath using thermally efficient pellets as the thermal media. The pellets are typically oblong metallic or oblong metallic-coated pellets with rounded edges, a hardened surface, a smooth polished finish, and characteristics that enable efficient thermal communication between the bath's thermal source, the pellets, and the items that are inserted into the mass of pellets. Further, the pellets are dry and moisture and gas impermeable, and they resist microbial growth and are readily decontaminated by several methods including applying an antimicrobial compound to the pellets. The thermal source is controlled to achieve the desired temperature of the items inserted into the pellets.
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公开(公告)号：US09794986B2
公开(公告)日：2017-10-17
申请号：US13410288
申请日：2012-03-01
申请人： Richard A Jarvis
发明人： Richard A Jarvis
CPC分类号： H05B1/0213 , A01N25/34 , C09K5/14 , A01N59/16 , A01N59/20
摘要： Systems and methods for controlling the temperature of items such as a sample in a vessel or a specimen, in a thermal bath using thermally efficient pellets as the thermal media. The pellets are typically oblong metallic or oblong metallic-coated pellets with rounded edges, a hardened surface, a smooth polished finish, and characteristics that enable efficient thermal communication between the bath's thermal source, the pellets, and the items that are inserted into the mass of pellets. Further, the pellets are dry and moisture and gas impermeable, and they resist microbial growth and are readily decontaminated by several methods including applying an antimicrobial compound to the pellets. The thermal source is controlled to achieve the desired temperature of the items inserted into the pellets.
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公开(公告)号：US20080274549A1
公开(公告)日：2008-11-06
申请号：US12123619
申请日：2008-05-20
IPC分类号： C12N15/87
CPC分类号： C12M35/02 , A61K48/00 , C12M23/28 , C12M45/07 , C12N15/86 , C12N2710/16632 , C12N2710/16643 , C12N2830/00 , C12N2830/008
摘要： A system and method are described for electroporating a sample that utilizes one or more sets of electrodes that are spaced apart in order to hold a surface tension constrained sample between the electrodes. The first electrode is connected to the lower body of the system while the second electrode is connected to the upper body. Both electrodes are connected to a pulse generator. Each electrode has a sample contact surface such that the first electrode and the second electrode may be positioned to hold a surface tension constrained sample between the two sample contact surfaces and the sample may receive a selected electric pulse.
摘要翻译： 描述了一种用于电穿孔样品的系统和方法，该样品利用间隔开的一组或多组电极，以便在电极之间保持表面张力约束的样品。 第一电极连接到系统的下体，而第二电极连接到上身。 两个电极连接到脉冲发生器。 每个电极具有样品接触表面，使得第一电极和第二电极可以被定位成在两个样品接触表面之间保持表面张力约束的样品，并且样品可以接收所选择的电脉冲。
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公开(公告)号：US06689217B2
公开(公告)日：2004-02-10
申请号：US10315567
申请日：2002-12-10
IPC分类号： B05C1902
CPC分类号： B05B13/0452 , B05C3/10
摘要： An apparatus for chemically treating a metal part which includes an immersion tank containing a liquid chemical treatment solution, a conveyor conveying parts over the immersion tank, immersing and removing the part and at least one spray nozzle assembly located above the immersion tank which is supported on a track extending to a side wall of the tank and permitting maintenance of the spray nozzle assembly without draining the tank.
摘要翻译： 一种用于化学处理金属部件的装置，其包括含有液体化学处理溶液的浸渍罐，在浸渍槽上方输送部分的输送器，浸渍和移除该部件以及位于浸没罐上方的至少一个喷嘴组件，所述喷嘴组件被支撑在 延伸到罐的侧壁的轨道，并且允许维护喷嘴组件而不排放罐。
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7.发明申请Thermal bath systems and thermally-conductive particulate thermal bath media and methods 审中-公开热浴系统和导热颗粒热浴介质和方法公开(公告)号：US20090233375A1
公开(公告)日：2009-09-17
申请号：US12381102
申请日：2009-03-06
申请人： Richard A. Jarvis
发明人： Richard A. Jarvis
摘要： Thermally-conductive laboratory bath media can be used to replace conventional wet media or dry solid blocks in existing thermal baths for heating or cooling samples with advantageous maintenance and microbial control benefits. The media is typically in the form of metallic or metallic-coated pellets that have rounded edges, hardened surface, a smooth polished finish, and are sized small for efficient thermal communication between pellets and samples. Laboratory bath improvements are disclosed with various advanced controls and adaptations for thermal control as well as infection control.
摘要翻译： 导热实验室浴介质可用于替代现有热浴中的常规湿介质或干固体块，用于加热或冷却样品，具有有利的维护和微生物控制优点。 介质通常是金属或金属涂层的颗粒的形式，其具有圆形边缘，硬化表面，光滑的抛光光洁度，并且尺寸较小，用于颗粒和样品之间的有效热连通。 公开了实验室浴的改进，其具有各种先进的控制和适应性，用于热控制以及感染控制。
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公开(公告)号：US08524680B2
公开(公告)日：2013-09-03
申请号：US12550625
申请日：2009-08-31
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1135 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/53 , C12N2320/50 , C12Y102/01012
摘要： The present invention provides improved methods of attenuating gene expression through the phenomenon of RNA interference. The invention provides methods of synthesis of double stranded RNAs (dsRNAs) of increased potency for use as small interfering RNA (siRNA). Surprisingly and unexpectedly, siRNAs made by the methods of the invention are significantly more potent than previously available siRNAs.
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公开(公告)号：US20100196998A1
公开(公告)日：2010-08-05
申请号：US12760526
申请日：2010-04-14
IPC分类号： C12M1/42
CPC分类号： C12M35/02 , A61K48/00 , C12M23/28 , C12M45/07 , C12N15/86 , C12N2710/16632 , C12N2710/16643 , C12N2830/00 , C12N2830/008
摘要： A system and method are described for electroporating a sample that utilizes one or more sets of electrodes that are spaced apart in order to hold a surface tension constrained sample between the electrodes. The first electrode is connected to the lower body of the system while the second electrode is connected to the upper body. Both electrodes are connected to a pulse generator. Each electrode has a sample contact surface such that the first electrode and the second electrode may be positioned to hold a surface tension constrained sample between the two sample contact surfaces and the sample may receive a selected electric pulse.
摘要翻译： 描述了一种用于电穿孔样品的系统和方法，该样品利用间隔开的一组或多组电极，以便在电极之间保持表面张力约束的样品。 第一电极连接到系统的下体，而第二电极连接到上身。 两个电极连接到脉冲发生器。 每个电极具有样品接触表面，使得第一电极和第二电极可以被定位成在两个样品接触表面之间保持表面张力约束的样品，并且样品可以接收所选择的电脉冲。
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公开(公告)号：US08017399B2
公开(公告)日：2011-09-13
申请号：US12123619
申请日：2008-05-20
IPC分类号： C12N15/87
CPC分类号： C12M35/02 , A61K48/00 , C12M23/28 , C12M45/07 , C12N15/86 , C12N2710/16632 , C12N2710/16643 , C12N2830/00 , C12N2830/008
摘要： A system and method are described for electroporating a sample that utilizes one or more sets of electrodes that are spaced apart in order to hold a surface tension constrained sample between the electrodes. The first electrode is connected to the lower body of the system while the second electrode is connected to the upper body. Both electrodes are connected to a pulse generator. Each electrode has a sample contact surface such that the first electrode and the second electrode may be positioned to hold a surface tension constrained sample between the two sample contact surfaces and the sample may receive a selected electric pulse.
摘要翻译： 描述了一种用于电穿孔样品的系统和方法，该样品利用间隔开的一组或多组电极，以便在电极之间保持表面张力约束的样品。 第一电极连接到系统的下体，而第二电极连接到上身。 两个电极连接到脉冲发生器。 每个电极具有样品接触表面，使得第一电极和第二电极可以被定位成在两个样品接触表面之间保持表面张力约束的样品，并且样品可以接收所选择的电脉冲。
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