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1.发明授权Device for delivering a radioactive and/or drug dosage alone or in connection with a vascular stent 有权用于单独或与血管支架相关的放射性和/或药物剂量的装置公开(公告)号：US06821296B2
公开(公告)日：2004-11-23
申请号：US09874580
申请日：2001-06-05
申请人： Richard A. Brauckman , Jack C. White , Bruce Smith
发明人： Richard A. Brauckman , Jack C. White , Bruce Smith
IPC分类号： A61F206
CPC分类号： A61F2/92 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2250/0067
摘要： A stent for insertion into a vessel of a body and used in connection with a foil sheet, where the foil sheet comprises a radioactive material, is described. The stent and foul sheet are positioned so that the radioactive material in the foil sheet can deliver a desired dosage to an prescribed area, thereby reducing the distance for delivering the radioactive dose. The radioactive material may comprise carrier-free palladium 103. The foils screen may further comprise a shielding lay on the side for directing the dosage. A method for placing the stent and foil into a vessel of a body is also described.
摘要翻译： 描述了用于插入到身体的容器中并且与箔片结合使用的支架，其中箔片包括放射性材料。 定位支架和污垢片，使得箔片中的放射性物质能够将期望的剂量输送到规定的面积，从而减少了输送放射性剂量的距离。 放射性材料可以包含无载体钯103.箔屏幕还可以包括用于引导剂量的侧面上的屏蔽层。 还描述了将支架和箔放置在身体的容器中的方法。
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2.发明授权公开(公告)号：US06790170B2
公开(公告)日：2004-09-14
申请号：US10010250
申请日：2001-11-07
IPC分类号： A61M3612
CPC分类号： A61N5/1002 , A61N2005/1025 , Y10T29/49801
摘要： A dual lumen catheter system for the positioning of a radioactive material for therapeutic radiation treatment of the body is disclosed. The dual lumen catheter includes a guidewire lumen and a blind lumen provided for introduction of a radiation source wire. The dual lumen catheter provides the advantage that the radiation source wire does not contact body tissue thereby eliminating the need for sterilization of the wire for reuse. Also disclosed are a radiation source wire having a tapered distal end of the wire core such that radioactive material and other components of the source wire can be applied to the outer surface thereof without exceeding a predetermined maximum outside diameter. Also disclosed is a source train cask for use with the catheter system and radiation source wire of the invention. The source train cask permits convenient handling and feeding of the radiation source wire without exposure of the medical personnel to radiation.
摘要翻译： 公开了一种用于定位用于身体的治疗性放射治疗的放射性物质的双腔导管系统。 双腔导管包括导丝管腔和设置用于引入辐射源线的盲腔。 双腔导管提供了这样的优点：辐射源线不接触身体组织，从而消除对电线进行灭菌以便重新使用的需要。 还公开了一种辐射源线，其具有线芯的锥形远端，使得放射性材料和源极线的其它部件可以被施加到其外表面而不超过预定的最大外径。 还公开了与本发明的导管系统和辐射源线一起使用的源列车桶。 源火车桶可以方便地处理和馈送辐射源线，而不会使医务人员暴露于辐射。
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公开(公告)号：US06749553B2
公开(公告)日：2004-06-15
申请号：US09858816
申请日：2001-05-16
IPC分类号： A61N500
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1025
摘要： Radiation delivery devices useful in brachytherapy which employ radioactive palladium-103 as the radiation source material are disclosed. Certain embodiments of the disclosed radiation delivery devices have the advantages that they can be fabricated with the desired specific activity, that the self-shielding effects of the devices are minimized, that the radioactive source material is bonded to a substrate in a manner which substantially prevents it from becoming detached, and that a variety of customizable radiation delivery devices can be made using the concepts of the invention. Also disclosed are processes for bonding radiation source material to various substrates using electroless plating, chemical vapor deposition and polymer matrices. These processes have the advantage that they can be applied to bond the radiation source material to a wide variety of substrates including different substrate materials and differently shaped substrates, thereby providing the ability to tailor the radiation delivery devices to the specific requirements of a particular brachytherapy treatment.
摘要翻译： 公开了使用放射性钯-103作为辐射源材料的用于近距离放射治疗的辐射递送装置。 所公开的辐射递送装置的某些实施例具有这样的优点：它们可以以期望的比活度制造，使得装置的自屏蔽作用最小化，放射源材料以基本上防止的方式结合到基底 它变得分离，并且可以使用本发明的概念制造各种可定制的辐射递送装置。 还公开了使用化学镀，化学气相沉积和聚合物基质将辐射源材料粘合到各种基底的方法。 这些方法具有这样的优点：它们可以用于将辐射源材料粘合到包括不同基底材料和不同形状的基底的各种基底上，从而提供根据特定近距离放射疗法治疗的具体要求来定制辐射递送装置的能力 。
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公开(公告)号：US06994688B2
公开(公告)日：2006-02-07
申请号：US09858366
申请日：2001-05-16
IPC分类号： A61M29/00
CPC分类号： A61N5/1002 , A61N2005/1004
摘要： A catheter for the positioning of a radioactive material for therapeutic radiation treatment of the body is disclosed. The catheter includes a radioactive source positioned at the distal end thereof and is sufficiently flexible and strong to navigate in the body to the desired treatment location. The radioactive source may be provided to the catheter in a number of different ways. In one set of embodiments, the radioactive source is bonded to the inner or outer surface of the catheter body, a catheter attachment or a carrier positionable within the catheter body. In another set of embodiments, one of the catheter body, catheter attachment or carrier positionable within the catheter body includes a cavity within which the radioactive source is placed. In this set of embodiments, the radioactive source may be provided in a variety of different forms, depending upon the particular needs of the treatment method. The radioactive source may also be immobilized in a polymeric material such as an elastomer, gel, hydrogel, foam or other similar deformable material. Finally, the catheter body or carrier may include a removable portion which provides access to the cavity within which the radioactive source is housed.
摘要翻译： 公开了一种用于定位用于体内治疗性放射治疗的放射性物质的导管。 导管包括位于其远端处的放射源，并且具有足够的柔性和强度以在体内导航到期望的治疗位置。 可以以多种不同的方式将放射源提供给导管。 在一组实施例中，放射源结合到导管主体的内表面或外表面，导管附件或可定位在导管主体内的载体。 在另一组实施例中，可以在导管主体内定位的导管主体，导管附接件或载体之一包括其中放置放射源的空腔。 在这组实施例中，放射源可以以各种不同形式提供，这取决于治疗方法的特定需要。 放射源也可以固定在聚合材料如弹性体，凝胶，水凝胶，泡沫或其它类似的可变形材料中。 最后，导管主体或载体可以包括提供对容纳放射源的腔的通路的可移除部分。
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