公开(公告)号：US09562960B2

公开(公告)日：2017-02-07

申请号：US12935968

申请日：2009-04-03

Applicant: Arunark Kolipaka ,  Armando Manduca ,  Kiaran P. Mcgee ,  Richard L. Ehman ,  Kevin J. Glaser

Inventor： Arunark Kolipaka ,  Armando Manduca ,  Kiaran P. Mcgee ,  Richard L. Ehman ,  Kevin J. Glaser

IPC: A61B5/055 ,  G01R33/563 ,  A61B5/00

CPC classification number: G01R33/56358 ,  A61B5/0051 ,  A61B5/416

Abstract: A method for magnetic resonance elastography (“MRE”) is described, in which an MRE inversion that accounts for waves propagating in a finite, bounded media is employed. A vibratory motion is induced in a subject and MRE is performed to measure one or more components of the resulting displacement produced in the subject. This displacement data is subsequently filtered to provide a more accurate and computationally efficient method of inversion. Wave equations based on the geometry of the bounded media are then utilized to calculate the material properties of the subject. Such a method allows for the performance of MRE on tissues such as the heart, eye, bladder, and prostate with more accurate results.

Abstract translation: 描述了一种用于磁共振弹性成像（“MRE”）的方法，其中采用考虑在有限的有界介质中传播的波的MRE反演。 在受试者中诱发振动，并执行MRE以测量在受试者中产生的所得到的位移的一个或多个成分。 随后对该位移数据进行滤波以提供更精确和计算上有效的反演方法。 然后利用基于有界介质的几何形状的波动方程来计算受试者的材料性质。 这种方法允许在更精确的结果上在诸如心脏，眼睛，膀胱和前列腺的组织上表现MRE。

公开(公告)号：US08727998B2

公开(公告)日：2014-05-20

申请号：US12599721

申请日：2008-05-15

Applicant: Meng Yin ,  Jayant A. Talwalkar ,  Anthony J. Romano ,  Armando Manduca ,  Richard L. Ehman

Inventor： Meng Yin ,  Jayant A. Talwalkar ,  Anthony J. Romano ,  Armando Manduca ,  Richard L. Ehman

IPC: A61B5/02

CPC classification number: A61B5/055 ,  A61B5/416 ,  A61B8/08 ,  A61B8/485

Abstract: The shear stiffness of a subject's spleen is measured using elastography techniques such as ultrasound elastography or a magnetic resonance elastography (MRE) acquisition with an MRI system. A relationship between splenic shear stiffness and portal venous blood pressure is modeled and is used to calculate portal venous blood pressure non-invasively from the measured splenic shear stiffness.

Abstract translation: 使用弹性成像技术测量受试者脾脏的剪切刚度，例如使用MRI系统进行超声弹性成像或磁共振弹性成像（MRE）采集。 模拟了剪切刚度和门静脉血压之间的关系，并用于从测量的脾剪切刚度非侵入地计算门静脉血压。

公开(公告)号：US20140107467A1

公开(公告)日：2014-04-17

申请号：US14049632

申请日：2013-10-09

Applicant: Joel P. Felmlee ,  Richard L. Ehman ,  Matthew C. Murphy

Inventor： Joel P. Felmlee ,  Richard L. Ehman ,  Matthew C. Murphy

IPC: G01R33/48 ,  A61B5/055 ,  A61B5/00 ,  A61B8/08

CPC classification number: G01R33/4814 ,  A61B5/0035 ,  A61B5/055 ,  A61B5/725 ,  A61B5/7278 ,  A61B8/485 ,  G01R33/56358

Abstract: A system and method for generating a magnetic resonance elastography (MRE) report includes a) acquiring MRE data from a subject including positively motion encoded medical imaging data and negatively motion encoded medical imaging data and b) deriving uncorrected difference medical imaging data from the MRE data for a given slice. The method also includes c) filtering the uncorrected difference medical imaging data to create filtered medical imaging data corrected for errors associated with phase ramps occurring during gradient switching used to derive the positively motion encoded medical imaging data and negatively motion encoded medical imaging data, d) generating a corrected difference image for the given slice from the filtered medical imaging data and the uncorrected difference medical imaging data, e) repeating steps b) through d) for each slice reflected in the MRE data, and f) generating a report of elastic properties of the subject from the corrected difference image.

Abstract translation: 用于产生磁共振弹性成像（MRE）报告的系统和方法包括：a）从主体获取MRE数据，包括正运动编码的医学成像数据和负运动编码的医学成像数据，以及b）从MRE数据导出未校正的差分医学成像数据 对于给定的切片。 该方法还包括：c）对未校正的差分医学成像数据进行滤波，以产生针对与用于导出正运动编码的医学成像数据和负运动编码的医学成像数据的梯形切换期间发生的相位斜坡相关的误差校正的滤波的医学成像数据，d） 从经滤波的医学成像数据和未校正的差分医学成像数据生成针对给定切片的校正差分图像，e）对在MRE数据中反映的每个切片重复步骤b）至d），以及f）生成弹性特性报告 从修正后的差分图像中获取。

公开(公告)号：US20140073906A1

公开(公告)日：2014-03-13

申请号：US14082587

申请日：2013-11-18

Applicant: Richard L. Ehman ,  Phillip J. Rossman ,  Jun Chen

Inventor： Richard L. Ehman ,  Phillip J. Rossman ,  Jun Chen

IPC: G01R33/563 ,  A61B5/055 ,  G01R33/48 ,  A61B8/08 ,  A61B8/00

CPC classification number: G01R33/56358 ,  A61B5/0051 ,  A61B5/055 ,  A61B8/4236 ,  A61B8/485 ,  G01R33/28 ,  G01R33/4814

Abstract: An acoustic driver system for use in applying an oscillating stress to a subject undergoing a magnetic resonance elastography (MRE) examination includes a flexible passive driver located in the bore of the magnet and in contact with the subject. A remotely located active driver is acoustically coupled to the passive driver and produces acoustic energy in response to an applied current. The passive driver produces shear waves in response to the acoustic energy and are directed into the body of the subject undergoing the MRE examination.

Abstract translation: 用于向经历磁共振弹性成像（MRE）检查的对象施加振荡应力的声学驱动器系统包括位于磁体的孔中并与对象接触的柔性被动驱动器。 远程定位的有源驱动器与无源驱动器声学耦合，并响应于所施加的电流产生声能。 被动驱动器响应于声能产生剪切波，并被引导到经历MRE检查的对象的身体中。

公开(公告)号：US20120259201A1

公开(公告)日：2012-10-11

申请号：US13435657

申请日：2012-03-30

Applicant: Jun Chen ,  David A. Woodrum ,  Kevin J. Glaser ,  Richard L. Ehman ,  Phillip J. Rossman

Inventor： Jun Chen ,  David A. Woodrum ,  Kevin J. Glaser ,  Richard L. Ehman ,  Phillip J. Rossman

IPC: A61B5/055 ,  A61M25/08 ,  A61M25/095 ,  A61N5/067

CPC classification number: A61B5/055 ,  A61B5/0051 ,  A61B18/22 ,  A61B2018/00577 ,  G01R33/285 ,  G01R33/56358

Abstract: A system and method for performing a magnetic resonance elastography (MRE) procedure using an MRI system to monitor operation of a medical device performing a medical procedure. The driver system includes a housing, a port located in the housing and connected to a driving power, and an inertial driver moved within the housing by the driving power. A passage is formed in the housing and extends from a first opening in the housing, through the inertial driver, and to a second opening in the housing. The inertial driver receives a medical device extending through the passage and engages the medical device to impart oscillatory motion thereto as the inertial driver is moved by the driving power. The imparted oscillatory motion travels along the medical device as a waveguide to deliver the oscillatory motion to tissue receiving the medical procedure to perform the MRE procedure.

Abstract translation: 一种使用MRI系统执行磁共振弹性成像（MRE）程序以监测执行医疗程序的医疗装置的操作的系统和方法。 驱动器系统包括壳体，位于壳体中并连接到驱动力的端口，以及通过驱动力在壳体内移动的惯性驾驶员。 通道形成在壳体中并且从壳体中的第一开口穿过惯性驱动器延伸到壳体中的第二开口。 惯性驾驶员接收通过通道延伸的医疗装置，并且当惯性驾驶员被驱动力移动时，该医疗装置接合医疗装置以给予振荡运动。 所施加的振荡运动沿着医疗装置作为波导传播，以将振荡运动传递到接收医疗过程的组织以执行MRE过程。

公开(公告)号：US06879155B2

公开(公告)日：2005-04-12

申请号：US10119972

申请日：2002-04-10

Applicant: Richard L.. Ehman ,  Philip J. Rossman

Inventor： Richard L.. Ehman ,  Philip J. Rossman

IPC: G01R33/483 ,  G01R33/563 ,  G01V3/00

CPC classification number: G01R33/4833 ,  G01R33/56308 ,  G01R33/56316

Abstract: Magnetic resonance acoustography images are acquired in real time using a one-dimensional magnetic resonance elastography (MRE) pulse sequence in which a column of tissue is excited. A spin-echo MRE pulse sequence and a gradient-echo MRE pulse sequence are described which employ a broadband motion sensitizing gradient that enables an asynchronous transducer to be used to produce the oscillatory stress in the subject tissues.

Abstract translation: 使用其中激发一列组织的一维磁共振弹性成像（MRE）脉冲序列实时获取磁共振声像图像。 描述了自旋回波MRE脉冲序列和梯度回波MRE脉冲序列，其采用宽带运动敏化梯度，其使异步换能器能够用于在主题组织中产生振荡应力。

公开(公告)号：US5977770A

公开(公告)日：1999-11-02

申请号：US719605

申请日：1996-09-25

Applicant: Richard L. Ehman

Inventor： Richard L. Ehman

IPC: G01R33/30 ,  A61B5/055 ,  G01R33/28 ,  G01R33/563 ,  G01V3/00

CPC classification number: G01R33/56358 ,  A61B5/0051 ,  A61B5/055 ,  G01R33/28 ,  G01R33/563

Abstract: A scan using an NMR imaging system is carried out while applying an oscillating stress to the object being imaged. An alternating magnetic field gradient synchronized with the applied stress is employed in the NMR imaging pulse sequence to detect and measure synchronous spin motion throughout the field of view. The direction of the alternating gradient and/or the applied stress may be changed to measure and image the elastic properties of the object.

Abstract translation: 在对成像对象施加振荡应力的同时进行使用NMR成像系统的扫描。 在NMR成像脉冲序列中采用与施加的应力同步的交变磁场梯度，以检测和测量整个视场中的同步旋转运动。 可以改变交替梯度和/或施加的应力的方向以测量和成像物体的弹性特性。

公开(公告)号：US5899858A

公开(公告)日：1999-05-04

申请号：US58624

申请日：1998-04-09

Applicant: Raja Muthupillai ,  Richard L. Ehman

Inventor： Raja Muthupillai ,  Richard L. Ehman

IPC: G01R33/563 ,  A61B5/055

CPC classification number: G01R33/56358

Abstract: The alternating magnetic field gradient used to sensitize an NMR signal to spin motion is modulated in amplitude with a window function to tailor it to the particular NMR measurement. In an MR elastography measurement, the gradient is a sinusoidal waveform having a frequency the same as an applied oscillatory stress, and the window function desensitizes the measurement to spin motions at other frequencies.

Abstract translation: 用于使NMR信号对自旋运动敏感的交变磁场梯度以幅度调制，具有窗函数，以将其定制到特定的NMR测量。 在MR弹性成像测量中，梯度是具有与施加的振荡应力相同的频率的正弦波形，并且窗口函数使测量在其它频率处的自旋运动脱敏。

公开(公告)号：US09149204B2

公开(公告)日：2015-10-06

申请号：US13453681

申请日：2012-04-23

Applicant: Richard L. Ehman ,  Jun Chen ,  Phillip J. Rossman

Inventor： Richard L. Ehman ,  Jun Chen ,  Phillip J. Rossman

IPC: A61B5/055 ,  A61B5/00 ,  A61B8/08

CPC classification number: A61B5/055 ,  A61B5/0051 ,  A61B8/485

Abstract: A flexible passive acoustic driver for use in an acoustic driver system which applies an oscillating stress to a subject undergoing a magnetic resonance elastography (MRE) examination which includes receiving acoustic pressure waves from an active driver through a tube and imparts pressure waves to a subject of an imaging procedure. In one configuration, the passive driver includes a flexible bag that forms the walls of an acoustic cavity, and a structure filling material located inside the acoustic cavity provides support for the flexible bag. The flexible bag conforms to the shape of the subject and may be held in place by an elastic band. The passive driver can have an integrated or detachable non-active push-on compartment which is rigid or semi-flexible to improve the human-driver mechanical coupling and the driver energy efficiency of converting acoustic pressure to mechanical vibration applied to a subject.

Abstract translation: 一种在声学驱动器系统中使用的灵活的无源声学驱动器，其向经历磁共振弹性成像（MRE）检查的对象施加振荡应力，该检查包括通过管接收来自主动驱动器的声压波并将压力波施加到 成像过程。 在一种配置中，被动驱动器包括形成声腔的壁的柔性袋，并且位于声腔内的结构填充材料为柔性袋提供支撑。 柔性袋符合被检者的形状，可以通过弹性带保持在适当的位置。 被动驱动器可以具有集成或可拆卸的非活动推动隔室，其是刚性或半柔性的，以改善人 - 驱动器机械耦合以及将声压转换为施加到对象的机械振动的驾驶员能量效率。

公开(公告)号：US09134393B2

公开(公告)日：2015-09-15

申请号：US14049632

申请日：2013-10-09

Applicant: Joel P. Felmlee ,  Richard L. Ehman ,  Matthew C. Murphy

Inventor： Joel P. Felmlee ,  Richard L. Ehman ,  Matthew C. Murphy

IPC: A61B5/055 ,  G01R33/48 ,  A61B8/08 ,  A61B5/00 ,  G01R33/563

CPC classification number: G01R33/4814 ,  A61B5/0035 ,  A61B5/055 ,  A61B5/725 ,  A61B5/7278 ,  A61B8/485 ,  G01R33/56358

Abstract: A system and method for generating a magnetic resonance elastography (MRE) report includes a) acquiring MRE data from a subject including positively motion encoded medical imaging data and negatively motion encoded medical imaging data and b) deriving uncorrected difference medical imaging data from the MRE data for a given slice. The method also includes c) filtering the uncorrected difference medical imaging data to create filtered medical imaging data corrected for errors associated with phase ramps occurring during gradient switching used to derive the positively motion encoded medical imaging data and negatively motion encoded medical imaging data, d) generating a corrected difference image for the given slice from the filtered medical imaging data and the uncorrected difference medical imaging data, e) repeating steps b) through d) for each slice reflected in the MRE data, and f) generating a report of elastic properties of the subject from the corrected difference image.

Abstract translation: 用于产生磁共振弹性成像（MRE）报告的系统和方法包括：a）从主体获取MRE数据，包括正运动编码的医学成像数据和负运动编码的医学成像数据，以及b）从MRE数据导出未校正的差分医学成像数据 对于给定的切片。 该方法还包括：c）对未校正的差分医学成像数据进行滤波，以产生针对与用于导出正运动编码的医学成像数据和负运动编码的医学成像数据的梯形切换期间发生的相位斜坡相关的误差校正的滤波的医学成像数据，d） 从经滤波的医学成像数据和未校正的差分医学成像数据生成针对给定切片的校正差分图像，e）对在MRE数据中反映的每个切片重复步骤b）至d），以及f）生成弹性特性报告 从修正后的差分图像中获取。