公开(公告)号：US09562960B2

公开(公告)日：2017-02-07

申请号：US12935968

申请日：2009-04-03

申请人： Arunark Kolipaka ,  Armando Manduca ,  Kiaran P. Mcgee ,  Richard L. Ehman ,  Kevin J. Glaser

发明人： Arunark Kolipaka ,  Armando Manduca ,  Kiaran P. Mcgee ,  Richard L. Ehman ,  Kevin J. Glaser

IPC分类号： A61B5/055 ,  G01R33/563 ,  A61B5/00

CPC分类号： G01R33/56358 ,  A61B5/0051 ,  A61B5/416

摘要： A method for magnetic resonance elastography (“MRE”) is described, in which an MRE inversion that accounts for waves propagating in a finite, bounded media is employed. A vibratory motion is induced in a subject and MRE is performed to measure one or more components of the resulting displacement produced in the subject. This displacement data is subsequently filtered to provide a more accurate and computationally efficient method of inversion. Wave equations based on the geometry of the bounded media are then utilized to calculate the material properties of the subject. Such a method allows for the performance of MRE on tissues such as the heart, eye, bladder, and prostate with more accurate results.

摘要翻译： 描述了一种用于磁共振弹性成像（“MRE”）的方法，其中采用考虑在有限的有界介质中传播的波的MRE反演。 在受试者中诱发振动，并执行MRE以测量在受试者中产生的所得到的位移的一个或多个成分。 随后对该位移数据进行滤波以提供更精确和计算上有效的反演方法。 然后利用基于有界介质的几何形状的波动方程来计算受试者的材料性质。 这种方法允许在更精确的结果上在诸如心脏，眼睛，膀胱和前列腺的组织上表现MRE。

公开(公告)号：US09750426B2

公开(公告)日：2017-09-05

申请号：US13301300

申请日：2011-11-21

申请人： Kiaran P McGee ,  Richard L Ehman ,  Stephen M Ansell ,  Yogesh K Mariappan ,  Jun Chen

发明人： Kiaran P McGee ,  Richard L Ehman ,  Stephen M Ansell ,  Yogesh K Mariappan ,  Jun Chen

IPC分类号： A61B5/055 ,  A61B5/00

CPC分类号： A61B5/055 ,  A61B5/0051

摘要： A system and method for determining a response of a tumor following a chemotherapy process includes the use of a magnetic resonance elastography (MRE) driver and a magnetic resonance imaging (MRI) system. The method includes controlling the MRE driver and the MRI system to acquire raw MRE data from the tumor, inverting the raw MRE data to produce an elastogram of the tumor, and determining a response of the tumor to the chemotherapy process from the elastogram.

公开(公告)号：US06307369B1

公开(公告)日：2001-10-23

申请号：US09614893

申请日：2000-07-12

申请人： Joel P. Felmlee ,  Kiaran P. McGee ,  Richard L. Ehman ,  Armando Manduca

发明人： Joel P. Felmlee ,  Kiaran P. McGee ,  Richard L. Ehman ,  Armando Manduca

IPC分类号： G01V300

CPC分类号： G01R33/56509 ,  G01R33/4822 ,  G01R33/5673

摘要： A three-dimensional image data set is acquired with an MRI system and autocorrected to reduce artifacts caused by subject motion during image acquisition. Correction for motion along one or two axes is performed by selecting a 2D slice of data and autocorrecting it to produce phase corrections that are then made to the entire 3D image data set. This may be repeated by autocorrecting an additional 2D slice perpendicular to the first 2D slice to produce phase corrections for the 3D image data set for motion along the third axis.

摘要翻译： 利用MRI系统获取三维图像数据集并进行自动校正，以减少在图像采集期间由被摄体运动引起的伪像。 通过选择2D切片数据并对其进行自动校正来执行沿着一个或两个轴的运动的校正，以产生对整个3D图像数据集进行相位校正。 这可以通过自动校正垂直于第一2D切片的附加2D切片来重复，以产生用于沿着第三轴的运动的3D图像数据集的相位校正。

公开(公告)号：US08952693B2

公开(公告)日：2015-02-10

申请号：US13453653

申请日：2012-04-23

申请人： David S Lake ,  Kiaran P McGee ,  Armando Manduca ,  Yogesh K Mariappan ,  Richard L Ehman

发明人： David S Lake ,  Kiaran P McGee ,  Armando Manduca ,  Yogesh K Mariappan ,  Richard L Ehman

IPC分类号： G01R33/563

CPC分类号： G01R33/56358

摘要： A method for calculating a mechanical property of a material using a magnetic resonance imaging (“MRI”) system is provided. The method is particularly robust to image data having low signal-to-noise ratio (“SNR”). An MRI system is used to acquire magnetic resonance elastography (“MRE”) data from a subject containing the material. Exemplary materials include lung tissue. Images are reconstructed from the MRE data and used to produce a wave image from which a spatial frequency spectrum is produced. A principal frequency of the spatial frequency spectrum is produced and used to calculate a mechanical property of the material. For example, shear stiffness may be calculated.

摘要翻译： 提供了使用磁共振成像（“MRI”）系统计算材料的机械特性的方法。 该方法对具有低信噪比（“SNR”）的图像数据特别鲁棒​​。 MRI系统用于从包含材料的受试者获取磁共振弹性成像（“MRE”）数据。 示例性材料包括肺组织。 从MRE数据重建图像，并用于产生从其产生空间频谱的波形图像。 产生空间频谱的主频率并用于计算材料的机械性能。 例如，可以计算剪切刚度。

公开(公告)号：US06647134B1

公开(公告)日：2003-11-11

申请号：US09595282

申请日：2000-06-15

申请人： Kiaran P. McGee ,  Joel Felmlee ,  Richard Ehman ,  Armando Manduca

发明人： Kiaran P. McGee ,  Joel Felmlee ,  Richard Ehman ,  Armando Manduca

IPC分类号： G06K900

CPC分类号： G01R33/56509 ,  G01R33/4822 ,  G01R33/5635 ,  G01R33/56572 ,  G01R33/5673 ,  G06T1/20 ,  G06T5/006 ,  G06T11/006 ,  G06T2211/412 ,  G06T2211/424

摘要： An MRA image is corrected for motion artifacts using an iterative, autocorrection process in which corrections are tried and the quality of the resulting reconstructed image is measured. Corrections are made to the acquired three-dimensional data while the metric which measures image quality is applied to a two-dimensional projection image.

摘要翻译： 使用迭代自动校正过程来校正运动伪影的MRA图像，其中尝试校正并测量所得到的重建图像的质量。 对所获取的三维数据进行校正，同时将测量图像质量的度量应用于二维投影图像。

公开(公告)号：US20120130227A1

公开(公告)日：2012-05-24

申请号：US13301300

申请日：2011-11-21

申请人： Kiaran P. McGee ,  Richard L. Ehman ,  Stephen M. Ansell ,  Yogesh K. Mariappan ,  Jun Chen

发明人： Kiaran P. McGee ,  Richard L. Ehman ,  Stephen M. Ansell ,  Yogesh K. Mariappan ,  Jun Chen

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B5/0051

摘要： A system and method for determining a response of a tumor following a chemotherapy process includes the use of a magnetic resonance elastography (MRE) driver and a magnetic resonance imaging (MRI) system. The method includes controlling the MRE driver and the MRI system to acquire raw MRE data from the tumor, inverting the raw MRE data to produce an elastogram of the tumor, and determining a response of the tumor to the chemotherapy process from the elastogram.

摘要翻译： 用于确定化疗后肿瘤反应的系统和方法包括使用磁共振弹性成像（MRE）驱动器和磁共振成像（MRI）系统。 该方法包括控制MRE驱动器和MRI系统从肿瘤获取原始MRE数据，反转原始MRE数据以产生肿瘤的弹性图，并从弹性图确定肿瘤对化疗过程的反应。

公开(公告)号：US07991449B2

公开(公告)日：2011-08-02

申请号：US11407759

申请日：2006-04-20

申请人： Richard L. Ehman ,  Kiaran P. McGee ,  Brian C. Goss ,  Joel P. Felmlee

发明人： Richard L. Ehman ,  Kiaran P. McGee ,  Brian C. Goss ,  Joel P. Felmlee

IPC分类号： A61B5/05

CPC分类号： A61B5/055 ,  A61B5/0051 ,  A61B5/08 ,  G01R33/56358

摘要： A noble gas is administered to a subject to fill the lungs and magnetic resonance elastography image data is acquired while vibrations are applied to the chest wall. Shear waves are established in the gas-filled lungs by the vibrations and a shear modulus image is reconstructed from the MRE image data that may be used in the diagnosis of lung disease.

摘要翻译： 向受试者施用惰性气体以填充肺，并且在振动施加到胸壁时获取磁共振弹性成像图像数据。 通过振动在气体填充的肺中建立剪切波，并且可以用于诊断肺部疾病的MRE图像数据重建剪切模量图像。

公开(公告)号：US20110025333A1

公开(公告)日：2011-02-03

申请号：US12847712

申请日：2010-07-30

申请人： Eric C. Ehman ,  Kiaran P. McGee ,  Richard L. Ehman

发明人： Eric C. Ehman ,  Kiaran P. McGee ,  Richard L. Ehman

IPC分类号： G01R33/20

CPC分类号： G01R33/56358

摘要： A magnetic resonance elastography (“MRE”) driver that can produce shear waves in a subject without relying on mode conversion of longitudinal waves is disclosed. More specifically, the MRE driver includes a pneumatic driver located remotely from a magnetic resonance imaging (“MRI”) system which is operable in response to an applied electrical current to oscillate, a pressure-activated driver that is positioned on a subject in the MRI system, and a tube that is in fluid communication, at one end, with the pneumatic driver. The pressure-activated driver includes a base plate and a driver plate having a region between them that receives the tube. Oscillations of the pneumatic driver produce a pressure wave in the tube that causes the driver plate to vibrate. The driver plate rests against the subject of interest to apply a corresponding shear oscillatory force to the subject during the MRE examination.

摘要翻译： 公开了一种能够在不依赖纵波的模式转换的情况下在受试者中产生剪切波的磁共振弹性成像（“MRE”）驱动器。 更具体地说，MRE驱动器包括一个位于远离磁共振成像（“MRI”）系统的气动驱动器，该系统可响应所施加的电流振荡而操作，压力激活的驱动器位于MRI中的受试者身上 系统和一个管，其一端与气动驱动器流体连通。 压力驱动的驱动器包括基板和驱动板，驱动板在它们之间具有容纳管的区域。 气动驱动器的振动在管中产生压力波，导致驱动器板振动。 驾驶员座椅抵靠感兴趣的主题，以在MRE检查期间向对象施加相应的剪切振荡力。

公开(公告)号：US06184682B2

公开(公告)日：2001-02-06

申请号：US09290817

申请日：1999-04-13

申请人： Richard L. Ehman ,  Joel P. Felmlee ,  Armando Manduca ,  Kiaran P. McGee

发明人： Richard L. Ehman ,  Joel P. Felmlee ,  Armando Manduca ,  Kiaran P. McGee

IPC分类号： G01V300

CPC分类号： G06T5/003 ,  G06T5/10 ,  G06T5/50 ,  G06T2207/10016 ,  G06T2207/10088 ,  G06T2207/20056 ,  G06T2207/30004 ,  G06T2207/30168

摘要： Navigator echo signals are acquired during an MRI scan in which image data is acquired. The navigator echo signals are used to estimate an initial correction of the acquired image data for patient motion during the scan. The initially corrected image data is then autocorrected in an iterative process which measures image quality and makes further corrections to the image data until the measured image quality is within tolerance.

摘要翻译： 在获取图像数据的MRI扫描期间获取导航回波信号。 导航回波信号用于估计在扫描期间所获取的图像数据的患者运动的初始校正。 然后在迭代过程中自动校正最初校正的图像数据，该迭代过程测量图像质量并进一步校正图像数据，直到测量的图像质量在容差内。

公开(公告)号：US08903151B2

公开(公告)日：2014-12-02

申请号：US13335080

申请日：2011-12-22

申请人： Zhonghao Bao ,  Scott O Stiving ,  Kiaran P McGee

发明人： Zhonghao Bao ,  Scott O Stiving ,  Kiaran P McGee

IPC分类号： G06K9/00 ,  G06K9/62

CPC分类号： G06K9/00214 ,  G06K9/6206

摘要： A system and method for assessing the operation of a imaging system, such as magnetic resonance imaging (MRI) system, is disclosed including a that computer is programmed to access an image of a phantom from image data, identify a plurality of seed point in the image of the phantom using a shape recognition algorithm, and rank combinations of the seed points using a pattern recognition algorithm using a priori information about the predefined pattern. The computer is programmed to rank the combinations of the seed points to generate an indication of an imaging quality characteristic of the imaging system.

摘要翻译： 公开了一种用于评估诸如磁共振成像（MRI）系统的成像系统的操作的系统和方法，包括：该计算机被编程为从图像数据访问体模的图像，在图像数据中识别多个种子点 使用形状识别算法的体模图像，以及使用使用关于预定图案的先验信息的模式识别算法对种子点进行排列组合。 计算机被编程为对种子点的组合进行排序以产生成像系统的成像质量特性的指示。