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1.发明申请USE OF THY1-FP TRANSGENIC MOUSE FOR THE IDENTIFICATION OF OPHTHALMIC AGENTS 审中-公开使用THI1-FP转基因小鼠鉴定眼科药物公开(公告)号：US20080188573A1
公开(公告)日：2008-08-07
申请号：US12025515
申请日：2008-02-04
申请人： Ji-Ye WEI , Richard L. ORNBERG , Gustav GRAFF
发明人： Ji-Ye WEI , Richard L. ORNBERG , Gustav GRAFF
CPC分类号： A61K49/0008 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/03
摘要： The present invention relates to the use of thy1-FP (fluorescent protein) non-human transgenic animals such as mice to screen for ophthalmic agents that can be used to treat corneal dry eye syndrome and/or retinal neuropathies associated with glaucoma and/or age-related macular degeneration. Such ophthalmic agents may be selected by assessing their ability to provide protection in ocular tissue.
摘要翻译： 本发明涉及使用thy1-FP（荧光蛋白）非人转基因动物如小鼠来筛选可用于治疗与青光眼和/或年龄相关的角膜干眼综合征和/或视网膜神经病变的眼科剂 相关性黄斑变性。 可以通过评估它们在眼组织中提供保护的能力来选择这样的眼科剂。
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公开(公告)号：US07004976B2
公开(公告)日：2006-02-28
申请号：US10702407
申请日：2003-11-05
申请人： Richard L. Ornberg , Kishore Udipi , Denis Forster , Dennis P. Riley , Kenneth B. Thurmond , Susan Henke , Kerry Brethaur , Saikat Joardar
发明人： Richard L. Ornberg , Kishore Udipi , Denis Forster , Dennis P. Riley , Kenneth B. Thurmond , Susan Henke , Kerry Brethaur , Saikat Joardar
IPC分类号： A61F2/02 , A61K31/715 , C08G37/08
CPC分类号： A61L27/20 , A61L31/042 , C07F13/005 , C07F15/025 , C08B15/00 , C08B15/05 , C08B37/00 , C08B37/003 , C08B37/0072 , C08G18/10 , C08G18/4854 , C08G18/6685 , C08G18/718 , C08G18/73 , C08H1/06 , C08L5/08 , C08G18/3228
摘要： This invention provides modified biopolymers comprising biopolymers attached to at least one non-proteinaceous catalyst capable of dismutating superoxide in the biological system or precursor ligand thereof. The invention further provides pharmaceutical compositions comprising the modified biopolymer and therapeutic methods comprising administering the modified biopolymer to a subject in need thereof.
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公开(公告)号：US20100204584A1
公开(公告)日：2010-08-12
申请号：US12704083
申请日：2010-02-11
IPC分类号： A61B6/00
CPC分类号： A61B3/101 , A61B3/107 , A61B3/14 , A61B5/0059 , G06T7/0012 , G06T2207/10012 , G06T2207/10056 , G06T2207/10064 , G06T2207/30041
摘要： The invention provides apparatuses and methods for detecting corneal surface defects. The methods and/or an apparatus of the invention can be used to detect corneal surface diseases, such as dry eye.
摘要翻译： 本发明提供了用于检测角膜表面缺陷的装置和方法。 本发明的方法和/或装置可用于检测诸如干眼症之类的角膜表面疾病。
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公开(公告)号：US09232889B2
公开(公告)日：2016-01-12
申请号：US12704083
申请日：2010-02-11
CPC分类号： A61B3/101 , A61B3/107 , A61B3/14 , A61B5/0059 , G06T7/0012 , G06T2207/10012 , G06T2207/10056 , G06T2207/10064 , G06T2207/30041
摘要： The invention provides apparatuses and methods for detecting corneal surface defects. The methods and/or an apparatus of the invention can be used to detect corneal surface diseases, such as dry eye.
摘要翻译： 本发明提供了用于检测角膜表面缺陷的装置和方法。 本发明的方法和/或装置可用于检测诸如干眼症之类的角膜表面疾病。
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公开(公告)号：US20110164218A1
公开(公告)日：2011-07-07
申请号：US13026659
申请日：2011-02-14
IPC分类号： A61B3/14
CPC分类号： A61B3/10 , G06T7/0012 , G06T2207/10012 , G06T2207/10056 , G06T2207/10064 , G06T2207/20056 , G06T2207/30041
摘要： The invention provides apparatuses and methods for detecting ocular surface defects. The methods and/or an apparatus of the invention can be used to detect ocular surface diseases, such as dry eye, uveitis, conjunctivitis, keratitis, keratoconjunctivitis, vernal keratoconjunctivitis (VKC), atopic keratoconjunctivitis (AKC), autoimmune disorders of the ocular surface, meibomianitis, conjunctival hyperemia, eyelid hyperemia, ocular rosacea, ocular inflammation, or eye lid swelling.
摘要翻译： 本发明提供了用于检测眼表面缺陷的装置和方法。 本发明的方法和/或装置可用于检测眼部表面疾病，例如干眼症，葡萄膜炎，结膜炎，角膜炎，角结膜炎，春季角膜结膜炎（VKC），特应性角膜结膜炎（AKC），眼表自身免疫性疾病 ，睑板炎，结膜充血，眼睑充血，眼红斑痤疮，眼部炎症或眼睑肿胀。
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公开(公告)号：US09241622B2
公开(公告)日：2016-01-26
申请号：US13026659
申请日：2011-02-14
CPC分类号： A61B3/10 , G06T7/0012 , G06T2207/10012 , G06T2207/10056 , G06T2207/10064 , G06T2207/20056 , G06T2207/30041
摘要： The invention provides methods for detecting ocular surface defects. The methods of the invention can be used to detect ocular surface diseases, such as dry eye, uveitis, conjunctivitis, keratitis, keratoconjunctivitis, vernal keratoconjunctivitis (VKC), atopic keratoconjunctivitis (AKC), autoimmune disorders of the ocular surface, meibomianitis, conjunctival hyperemia, eyelid hyperemia, ocular rosacea, ocular inflammation, or eye lid swelling.
摘要翻译： 本发明提供了用于检测眼表面缺陷的方法。 本发明的方法可用于检测眼部表面疾病，例如干眼症，葡萄膜炎，结膜炎，角膜炎，角膜结膜炎，春季角膜结膜炎（VKC），特应性角膜结膜炎（AKC），眼表自身免疫性疾病，睑板炎，结膜充血 ，眼睑充血，眼红斑痤疮，眼部炎症或眼睑肿胀。
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