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公开(公告)号：US06465524B2
公开(公告)日：2002-10-15
申请号：US09892363
申请日：2001-06-27
IPC分类号： A61K31135
CPC分类号： A61K31/137 , A61K31/135
摘要： This invention provides a method of treating obesity, generalized anxiety disorder, post-traumatic stress disorder, late luteal phase disphoric disorder (premenstrual syndrome), attention deficit disorder, with and without hyperactivity, Gilles de la Tourette syndrome, bulimia nervosa or Shy Drager Syndrome in a mammal by administering to the mammal an effective amount of a hydroxycycloalkanephenethyl amine of the following structural formula: in which A is a moiety of the formula where the dotted line represents optional unsaturation; R1 is hydrogen or alkyl; R2 is alkyl; R4 is hydrogen, alkyl, formyl, or alkanol; R5 and R6 are, independently, hydrogen, hydroxyl, alkyl, alkoxy, alkanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alkanamido, halo, trifluoromethyl, or taken together, methylene dioxy; R7 is hydrogen or alkyl; and n is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供一种治疗肥胖症，广泛性焦虑症，创伤后应激障碍，晚黄体期无症状（经前期综合征），注意缺陷障碍，伴有和不伴有多动症的方法，Gilles de la Tourette综合征，神经性贪食症或Shy Drager综合征 在哺乳动物中通过向哺乳动物施用有效量的以下结构式的羟基环烷基苯乙胺：其中A是缬氨酸的部分，虚线代表任选的不饱和基团; R 1是氢或烷基; R 2是烷基; R 4是氢， 烷基，烷基或链烷醇; R 5和R 6独立地是氢，羟基，烷基，烷氧基，烷酰氧基，氰基，硝基，烷基巯基，氨基，烷基氨基，二烷基氨基，烷酰氨基，卤素，三氟甲基， 是氢或烷基; 和n为0,1,2,3或4;或其药学上可接受的盐。
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2.发明授权
公开(公告)号：US5506270A
公开(公告)日：1996-04-09
申请号：US380903
申请日：1995-01-30
IPC分类号： A61K31/135 , A61K31/13 , A61K31/137 , A61P13/02 , A61P15/00 , A61P43/00 , A61K31/045 , A01N31/00
CPC分类号： A61K31/137 , Y10S514/899
摘要： This invention provides a method for treating hypothalamic amenorrhea in a non-depressed female mammal by administering to the mammal an effective amount of a hydroxycycloalkanephenethyl amine compound of the following structural formula: ##STR1## in which A is a moiety of the formula ##STR2## wherein the dotted line represents optional unsaturation;R.sub.1 is hydrogen or alkyl;R.sub.2 is alkyl;R.sub.4 is hydrogen, alkyl, formyl, or alkanol;R.sub.5 and R.sub.6 are, independently, hydrogen, hydroxyl, alkyl, alkoxy, alkanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alkanamido, halo, trifluoromethyl, or taken together, methylene dioxy;R.sub.7 is hydrogen or alkyl; andn is 0, 1, 2, 3, or 4;or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供了一种通过向哺乳动物施用有效量的下列结构式的羟基环烷基甲苯胺化合物来治疗非抑郁女性哺乳动物的下丘脑闭经的方法：其中A是下式的部分：IMAGE> 其中虚线表示任选的不饱和键; R1是氢或烷基; R2是烷基; R4是氢，烷基，甲酰基或烷醇; R 5和R 6独立地是氢，羟基，烷基，烷氧基，烷酰氧基，氰基，硝基，烷基巯基，氨基，烷基氨基，二烷基氨基，烷酰氨基，卤素，三氟甲基或一起，亚甲基二氧基; R7是氢或烷基; 且n为0,1,2,3或4; 或其药学上可接受的盐。
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公开(公告)号：US20080176950A1
公开(公告)日：2008-07-24
申请号：US11841636
申请日：2007-08-20
IPC分类号： A61K31/137
CPC分类号： A61K31/137 , A61K31/135
摘要： This; invention provides a method of treating obesity, generalized anxiety disorder, post-traumatic stress disorder, late luteal phase dysphoric disorder (premenstrual, syndrome), attention deficit disorder, with and without hyperactivity, Gilles de la Tourette syndrome, bulimia nervosa or Shy Drager Syndrome in a: mammal by administering to the mammal an effective amount of a hydroxycycloalkanephenethyl amine of the following structural formula: in which A is a moiety of the formula where the dotted line represents optional unsaturation; R1 is hydrogen or alkyl; R2 is alkyl; R4 is hydrogen, alkyl, formyl, or alkanol; R5 and R6 are, independently, hydrogen, hydroxyl, alkyl, alkoxy, alkanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alkanamido, halo, trifluoromethyl, or taken together, methylene dioxy; R7 is hydrogen or alkyl; and n is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof:
摘要翻译： 这个; 本发明提供了一种治疗肥胖，广泛性焦虑症，创伤后应激障碍，晚黄体期烦躁障碍（经前期，综合征），注意缺陷障碍，伴有和不伴有多动症的方法，Gilles de la Tourette综合征，神经性贪食症或Shy Drager综合征 在哺乳动物中通过向哺乳动物施用有效量的以下结构式的羟基环烷基苯乙胺：其中A是下式的部分，其中虚线表示任选的不饱和度; R 1是氢或烷基; R 2是烷基; R 4是氢，烷基，甲酰基或链烷醇; R 5和R 6独立地是氢，羟基，烷基，烷氧基，烷酰氧基，氰基，硝基，烷基巯基，氨基，烷基氨基，二烷基氨基，烷酰氨基，卤素，三氟甲基 ，或一起取代亚甲基二氧基; R 7是氢或烷基; 且n为0,1,2,3或4; 或其药学上可接受的盐：
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公开(公告)号：US06444708B2
公开(公告)日：2002-09-03
申请号：US09769998
申请日：2001-01-25
IPC分类号： A61K31135
CPC分类号： A61K31/137 , A61K31/135
摘要： This invention provides a method of treating obesity, generalized anxiety disorder, post-traumatic stress disorder, late luteal phase disphoric disorder (premenstrual syndrome), attention deficit disorder, with and without hyperactivity, Gilles de la Tourette syndrome, bulimia nervosa or Shy Drager Syndrome in a mammal by administering to the mammal an effective amount of a hydroxycycloalkanephenethyl amine of the following structural formula: in which A is a moiety of the formula where the dotted line represents optional unsaturation; R1 is hydrogen or alkyl; R2 is alkyl; R4 is hydrogen, alkyl, formyl, or alkanol; R5 and R6 are, independently, hydrogen, hydroxyl, alkyl, alkoxy, alkanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alkanamido, halo, trifluoromethyl, or taken together, methylene dioxy; R7 is hydrogen or alkyl; and n is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供一种治疗肥胖症，广泛性焦虑症，创伤后应激障碍，晚黄体期无症状（经前期综合征），注意缺陷障碍，伴有和不伴有多动症的方法，Gilles de la Tourette综合征，神经性贪食症或Shy Drager综合征 在哺乳动物中通过向哺乳动物施用有效量的以下结构式的羟基环烷基苯乙胺：其中A是缬氨酸的部分，虚线代表任选的不饱和基团; R 1是氢或烷基; R 2是烷基; R 4是氢， 烷基，烷基或链烷醇; R 5和R 6独立地是氢，羟基，烷基，烷氧基，烷酰氧基，氰基，硝基，烷基巯基，氨基，烷基氨基，二烷基氨基，烷酰氨基，卤素，三氟甲基， 是氢或烷基; 和n为0,1,2,3或4;或其药学上可接受的盐。
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公开(公告)号：US06555586B2
公开(公告)日：2003-04-29
申请号：US09996590
申请日：2001-11-30
IPC分类号： A61K31135
CPC分类号： A61K31/137 , A61K31/135
摘要： This invention provides a method of treating obesity, generalized anxiety disorder, post-traumatic stress disorder, late luteal phase disphoric disorder (premenstrual syndrome), attention deficit disorder, with and without hyperactivity, Gilles de la Tourette syndrome, bulimia nervosa or Shy Drager Syndrome in a mammal by administering to the mammal an effective amount of a hydroxycycloalkanephenethyl amine of the following structural formula: in which A is a moiety of the formula where the dotted line represents optional unsaturation; R1 is hydrogen or alkyl; R2 is alkyl; R4 is hydrogen, alkyl, formyl, or alkanol; R5 and R6 are, independently, hydrogen, hydroxyl, alkyl, alkoxy, alkanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alkanamido, halo, trifluoromethyl, or taken together, methylene dioxy; R7 is hydrogen or alkyl; and n is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US06310101B1
公开(公告)日：2001-10-30
申请号：US09285812
申请日：1999-04-02
IPC分类号： A61K31135
CPC分类号： A61K31/137 , A61K31/135
摘要： This invention provides a method of treating obesity, generalized anxiety disorder, post-traumatic stress disorder, late luteal phase disphoric disorder (premenstrual syndrome), attention deficit disorder, with and without hyperactivity, Gilles de la Tourette syndrome, bulimia nervosa or Shy Drager Syndrome in a mammal by administering to the mammal an effective amount of a hydroxycycloalkanephenethyl amine of the following structural formula: in which A is a moiety of the formula where the dotted line represents optional unsaturation; R1 is hydrogen or alkyl; R2 is alkyl; R4 is hydrogen, alkyl, formyl, or alkanol; R5 and R6 are, independently, hydrogen, hydroxyl, alkyl, alkoxy, alkanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alkanamido, halo, trifluoromethyl, or taken together, methylene dioxy; R7 is hydrogen or alkyl; and n is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供一种治疗肥胖症，广泛性焦虑症，创伤后应激障碍，晚黄体期无症状（经前期综合征），注意缺陷障碍，伴有和不伴有多动症的方法，Gilles de la Tourette综合征，神经性贪食症或Shy Drager综合征 在哺乳动物中通过向哺乳动物施用有效量的以下结构式的羟基环烷基苯乙胺：其中A是缬氨酸的部分，虚线代表任选的不饱和基团; R 1是氢或烷基; R 2是烷基; R 4是氢， 烷基，烷基或链烷醇; R 5和R 6独立地是氢，羟基，烷基，烷氧基，烷酰氧基，氰基，硝基，烷基巯基，氨基，烷基氨基，二烷基氨基，烷酰氨基，卤素，三氟甲基， 是氢或烷基; 和n为0,1,2,3或4;或其药学上可接受的盐。
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公开(公告)号：US06730706B2
公开(公告)日：2004-05-04
申请号：US10396043
申请日：2003-03-25
IPC分类号： A61K31135
CPC分类号： A61K31/137 , A61K31/135
摘要： This invention provides a method of treating obesity, generalized anxiety disorder, post-traumatic stress disorder, late luteal phase dysphoric disorder (premenstrual syndrome), attention deficit disorder, with and without hyperactivity, Gilles de la Tourette syndrome, bulimia nervosa or Shy Drager Syndrome in a mammal by administering to the mammal an effective amount of a hydroxycycloalkanephenethyl amine of the following structural formula: in which A is a moiety of the formula where the dotted line represents optional unsaturation; R1 is hydrogen or alkyl; R2 is alkyl; R4 is hydrogen, alkyl, formyl, or alkanol; R5 and R6 are, independently, hydrogen, hydroxyl, alkyl, alkoxy, alkanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alkanamido, halo, trifluoromethyl, or taken together, methylene dioxy; R7 is hydrogen or alkyl; and n is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供了一种治疗肥胖症，广泛性焦虑症，创伤后应激障碍，晚黄体期烦躁障碍（经前期综合征），注意缺陷障碍，伴有和不伴有多动症的方法，Gilles de la Tourette综合征，神经性贪食症或Shy Drager综合征 在哺乳动物中通过向哺乳动物施用有效量的以下结构式的羟基环烷基苯乙胺：其中A是缬氨酸的部分，虚线代表任选的不饱和基团; R 1是氢或烷基; R 2是烷基; R 4是氢， 烷基，烷基或链烷醇; R 5和R 6独立地是氢，羟基，烷基，烷氧基，烷酰氧基，氰基，硝基，烷基巯基，氨基，烷基氨基，二烷基氨基，烷酰氨基，卤素，三氟甲基， 是氢或烷基; 和n为0,1,2,3或4;或其药学上可接受的盐。
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公开(公告)号：US5916923A
公开(公告)日：1999-06-29
申请号：US835780
申请日：1997-04-08
IPC分类号： A61K31/135 , A61K31/137 , A61P3/04 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/26
CPC分类号： A61K31/137 , A61K31/135
摘要： This invention provides a method of treating obesity, generalized anxiety disorder, post-traumatic stress disorder, late luteal phase disphoric disorder (premenstrual syndrome), attention deficit disorder, with and without hyperactivity, Gilles de la Tourette syndrome, bulimia iervosa or Shy Drager Syndrome in a mammal by administering to the mammal an effective amount of a hydroxycycloalkanephenethyl amine of the following structural formula: ##STR1## in which A is a moiety of the formula ##STR2## where the dotted line represents optional unsaturation;R.sub.1 is hydrogen or alkyl;R.sub.2 is alkyl;R.sub.4 is hydrogen, alkyl, formyl, or alkanol;R.sub.5 and R.sub.6 are, independently, hydrogen, hydroxyl, aakyl, alkoxy, alkanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alkanamido, halo, trifluoromethyl, or taken together, methylene dioxy;R.sub.7 is hydrogen or alkyl; andn is 0, 1, 2, 3, or 4;or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供了一种治疗肥胖症，广泛性焦虑症，创伤后应激障碍，晚黄体期无症状（经前期综合征），注意缺陷障碍，伴有和不伴有多动症，Gilles de la Tourette综合征，贪食症或Shy Drager综合征的方法 在哺乳动物中通过向哺乳动物施用有效量的以下结构式的羟基环烷基苯乙胺：其中A是下式的部分，其中虚线表示任选的不饱和度; R1是氢或烷基; R2是烷基; R4是氢，烷基，甲酰基或烷醇; R 5和R 6独立地是氢，羟基，芳烷基，烷氧基，烷酰氧基，氰基，硝基，烷基巯基，氨基，烷基氨基，二烷基氨基，烷酰氨基，卤素，三氟甲基，或一起形成亚甲基二氧基; R7是氢或烷基; 且n为0,1,2,3或4; 或其药学上可接受的盐。
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公开(公告)号：US5687512A
公开(公告)日：1997-11-18
申请号：US646857
申请日：1996-05-08
摘要： A lockdown system for a low rise building including a roof structure with sheathing disposed over a plurality of roof rafters, the roof structure forming eaves around the periphery thereof, the system comprises a loop of rafter cable for being secured around the eaves of the roof; and a plurality of anchor cables operably secured to the rafter and to the ground, the anchor cables being adapted to exert a downward force on the rafter such that lift forces generated during high winds are counteracted.
摘要翻译： 一种用于低层建筑物的锁定系统，其包括设置在多个屋顶椽子上的护套的屋顶结构，所述屋顶结构在其周围形成屋檐，所述系统包括用于固定在屋顶的屋檐周围的椽子线环; 以及可操作地固定到椽子和地面上的多个锚固缆索，锚索适用于在椽子上施加向下的力，使得在大风期间产生的提升力被抵消。
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