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1.发明授权Peptides having binding affinity to an antibody which recognizes an epitope on an α1 loop 2 or β2 loop 1 of an adrenoreceptor 有权具有与识别肾上腺素受体的α1环2或β2环1上的表位的抗体结合亲和力的肽公开(公告)号：US08455442B2
公开(公告)日：2013-06-04
申请号：US12735416
申请日：2009-01-15
申请人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
发明人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
CPC分类号： C07K17/08 , A61K38/08 , A61K38/1787 , B01J20/286 , B01J20/3251 , C07K14/723 , C07K16/28 , C07K2317/34
摘要： A peptide having an ED50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular α1 loop 2 or β2 loop 1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of γ-secretase activity, an increased release of β-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED50 value is measured by bioassay.
摘要翻译： 具有小于500nm的ED 50，特别是10nM的肽，其识别人肾上腺素受体的细胞外α1环2或β2环1上的表位的抗体，其中抗体与表位的结合导致γ- 分泌酶活性，β-固体分子的增加释放和/或脑血管细胞，神经胶质细胞或神经元的细胞功能障碍，其中ED 50值通过生物测定来测量。
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2.发明申请PEPTIDES HAVING BINDING AFFINITY TO AN ANTIBODY WHICH RECOGNIZES AN EPITOPE ON AN A1 LOOP 2 OR BETA2 LOOP 1 OF AN ADRENORECEPTOR 有权具有结合亲和性的肽可以识别在ADRENORECEPTOR的A1环2或BETA2环1上的抗原决定簇公开(公告)号：US20110104226A1
公开(公告)日：2011-05-05
申请号：US12735416
申请日：2009-01-15
申请人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
发明人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
IPC分类号： A61K9/00 , A61K39/00 , C07K16/18 , C07H21/04 , C07H21/02 , C12N15/63 , C12N5/10 , B01J20/22 , B01J20/26 , A61K31/7088 , A61K35/12 , A61P25/28 , A61K31/711 , A61K31/7105
CPC分类号： C07K17/08 , A61K38/08 , A61K38/1787 , B01J20/286 , B01J20/3251 , C07K14/723 , C07K16/28 , C07K2317/34
摘要： A peptide having an ED50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular α1 loop 2 or β2 loop 1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of γ-secretase activity, an increased release of β-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED50 value is measured by bioassay.
摘要翻译： 具有小于500nm的ED 50，特别是10nM的肽，其识别人肾上腺素受体的细胞外α1环2或第2环1上的表位的抗体，其中抗体与表位的结合导致增加 γ-分泌酶活性，增加的β-固体分子释放和/或脑血管细胞，神经胶质细胞或神经元的细胞功能障碍，其中通过生物测定法测量ED 50值。
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