-
1.发明申请PEPTIDES HAVING BINDING AFFINITY TO AN ANTIBODY WHICH RECOGNIZES AN EPITOPE ON AN A1 LOOP 2 OR BETA2 LOOP 1 OF AN ADRENORECEPTOR 有权具有结合亲和性的肽可以识别在ADRENORECEPTOR的A1环2或BETA2环1上的抗原决定簇公开(公告)号：US20110104226A1
公开(公告)日：2011-05-05
申请号：US12735416
申请日：2009-01-15
申请人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
发明人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
IPC分类号： A61K9/00 , A61K39/00 , C07K16/18 , C07H21/04 , C07H21/02 , C12N15/63 , C12N5/10 , B01J20/22 , B01J20/26 , A61K31/7088 , A61K35/12 , A61P25/28 , A61K31/711 , A61K31/7105
CPC分类号： C07K17/08 , A61K38/08 , A61K38/1787 , B01J20/286 , B01J20/3251 , C07K14/723 , C07K16/28 , C07K2317/34
摘要： A peptide having an ED50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular α1 loop 2 or β2 loop 1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of γ-secretase activity, an increased release of β-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED50 value is measured by bioassay.
摘要翻译： 具有小于500nm的ED 50，特别是10nM的肽，其识别人肾上腺素受体的细胞外α1环2或第2环1上的表位的抗体，其中抗体与表位的结合导致增加 γ-分泌酶活性，增加的β-固体分子释放和/或脑血管细胞，神经胶质细胞或神经元的细胞功能障碍，其中通过生物测定法测量ED 50值。
-
2.发明授权Peptides having binding affinity to an antibody which recognizes an epitope on an α1 loop 2 or β2 loop 1 of an adrenoreceptor 有权具有与识别肾上腺素受体的α1环2或β2环1上的表位的抗体结合亲和力的肽公开(公告)号：US08455442B2
公开(公告)日：2013-06-04
申请号：US12735416
申请日：2009-01-15
申请人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
发明人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
CPC分类号： C07K17/08 , A61K38/08 , A61K38/1787 , B01J20/286 , B01J20/3251 , C07K14/723 , C07K16/28 , C07K2317/34
摘要： A peptide having an ED50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular α1 loop 2 or β2 loop 1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of γ-secretase activity, an increased release of β-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED50 value is measured by bioassay.
摘要翻译： 具有小于500nm的ED 50，特别是10nM的肽，其识别人肾上腺素受体的细胞外α1环2或β2环1上的表位的抗体，其中抗体与表位的结合导致γ- 分泌酶活性，β-固体分子的增加释放和/或脑血管细胞，神经胶质细胞或神经元的细胞功能障碍，其中ED 50值通过生物测定来测量。
-
公开(公告)号：US20130272325A1
公开(公告)日：2013-10-17
申请号：US13467890
申请日：2012-05-09
申请人： Peter Rosenthal , John Kennedy , Vern Seguin , David Allie
发明人： Peter Rosenthal , John Kennedy , Vern Seguin , David Allie
IPC分类号： H01S3/10
CPC分类号： H01S3/104 , H01S3/09705 , H01S3/10046 , H01S3/10069 , H01S3/2232
摘要： In order to maintain a constant laser output pulse power in a RF-energized, sealed-off, diffusion cooled, pulsed, CO2 gas-discharge laser, each laser output pulse is generated by train or burst of shorter RF pulses. When the time between laser output pulses becomes short enough that the power in one pulse would be reduced by gas-discharge heating effects of a previous pulse, power in the RF pulse trains is varied by varying the duration or duty cycle of pulses in the bursts, thereby keeping output-pulse power in the laser output pulses constant. RF pulses in any burst can have a different duration for tailoring the temporal shape of a corresponding laser-output pulse.
摘要翻译： 为了在射频激励，密封的扩散冷却脉冲的CO2气体放电激光器中保持恒定的激光输出脉冲功率，每个激光输出脉冲由较短的RF脉冲的串联或脉冲串产生。 当激光输出脉冲之间的时间变得足够短以致通过先前脉冲的气体放电加热效应将一个脉冲中的功率降低时，通过改变脉冲串中的脉冲的持续时间或占空比来改变RF脉冲串中的功率 从而保持激光输出脉冲中的输出脉冲功率恒定。 任何脉冲串中的RF脉冲可以具有不同的持续时间，用于调整对应的激光输出脉冲的时间形状。
-
公开(公告)号：US08362428B2
公开(公告)日：2013-01-29
申请号：US12668267
申请日：2008-06-05
申请人： John Berriman , Peter Rosenthal
发明人： John Berriman , Peter Rosenthal
CPC分类号： H01J37/026 , H01J37/26 , H01J2237/0045 , H01J2237/0453 , H01J2237/1514
摘要： A transmission electron microscope has a target body position on the electron optical axis of the microscope, and an electrically conductive body off the axis of the microscope. The microscope also has an electron source for producing an axial electron beam. In use, the beam impinges upon a target body located at the target body position. The microscope further has a system for simultaneously producing a separate off-axis electron beam. In use, the off-axis electron beam impinges on the electrically conductive body causing secondary electrons to be emitted therefrom. The electrically conductive body is located such that the emitted secondary electrons impinge on the target body to neutralise positive charge which may build up on the target body.
摘要翻译： 透射电子显微镜在显微镜的电子光轴上具有目标体位置，并且离开显微镜轴线的导电体。 显微镜还具有用于产生轴向电子束的电子源。 在使用中，梁撞击位于目标体位置的目标体。 显微镜还具有同时产生单独的离轴电子束的系统。 在使用中，离轴电子束照射在导电体上，导致从其发射二次电子。 导电体被定位成使得发射的二次电子撞击目标体以中和可能在目标体上累积的正电荷。
-
公开(公告)号：US07839509B2
公开(公告)日：2010-11-23
申请号：US11994763
申请日：2006-06-30
IPC分类号： G01B11/02
CPC分类号： G01B11/0625
摘要： The invention represents an improved method of measuring trenches on semiconductor wafers with optical spectroscopy. According to the described method, it is possible to characterize not only depth but also shape of the trench. The advancement is achieved by improved Effective Medium Approximation-based modeling of the optical response of trench structures.
摘要翻译： 本发明代表用光谱法测量半导体晶片上的沟槽的改进方法。 根据所描述的方法，不仅可以表征沟槽的深度，还可以表征沟槽的形状。 通过改进对沟槽结构的光学响应的基于有效介质近似的建模来实现进步。
-
6.发明申请公开(公告)号：US20090122321A1
公开(公告)日：2009-05-14
申请号：US11994763
申请日：2006-06-30
IPC分类号： G01B11/22
CPC分类号： G01B11/0625
摘要： The invention represents an improved method of measuring trenches on semiconductor wafers with optical spectroscopy. According to the described method, it is possible to characterize not only depth but also shape of the trench. The advancement is achieved by improved Effective Medium Approximation-based modeling of the optical response of trench structures.
摘要翻译： 本发明代表用光谱法测量半导体晶片上的沟槽的改进方法。 根据所描述的方法，不仅可以表征沟槽的深度，还可以表征沟槽的形状。 通过改进对沟槽结构的光学响应的基于有效介质近似的建模来实现进步。
-
公开(公告)号：US08687661B2
公开(公告)日：2014-04-01
申请号：US13467890
申请日：2012-05-09
申请人： Peter Rosenthal , John Kennedy , Vern Seguin , David Allie
发明人： Peter Rosenthal , John Kennedy , Vern Seguin , David Allie
IPC分类号： H01S3/10
CPC分类号： H01S3/104 , H01S3/09705 , H01S3/10046 , H01S3/10069 , H01S3/2232
摘要： In order to maintain a constant laser output pulse power in a RF-energized, sealed-off, diffusion cooled, pulsed, CO2 gas-discharge laser, each laser output pulse is generated by train or burst of shorter RF pulses. When the time between laser output pulses becomes short enough that the power in one pulse would be reduced by gas-discharge heating effects of a previous pulse, power in the RF pulse trains is varied by varying the duration or duty cycle of pulses in the bursts, thereby keeping output-pulse power in the laser output pulses constant. RF pulses in any burst can have a different duration for tailoring the temporal shape of a corresponding laser-output pulse.
摘要翻译： 为了在射频激励，密封的扩散冷却脉冲的CO2气体放电激光器中保持恒定的激光输出脉冲功率，每个激光输出脉冲由较短的RF脉冲的串联或脉冲串产生。 当激光输出脉冲之间的时间变得足够短以致通过先前脉冲的气体放电加热效应将一个脉冲中的功率降低时，通过改变脉冲串中的脉冲的持续时间或占空比来改变RF脉冲串中的功率 从而保持激光输出脉冲中的输出脉冲功率恒定。 任何脉冲串中的RF脉冲可以具有不同的持续时间，用于调整对应的激光输出脉冲的时间形状。
-
8.发明申请Linked extendable gas observation system for infrared absorption spectroscopy 审中-公开用于红外吸收光谱的连接可扩展气体观测系统公开(公告)号：US20070182965A1
公开(公告)日：2007-08-09
申请号：US11529694
申请日：2006-09-28
申请人： Leonard Kamlet , Martin Spartz , Peter Rosenthal
发明人： Leonard Kamlet , Martin Spartz , Peter Rosenthal
CPC分类号： G01N21/05 , G01N21/3504 , G01N2201/0245
摘要： A modular system for gas analysis has a first gas cell that receives and passes at least a portion of an infrared light beam through at least a portion of the first gas cell. A second gas cell disposed proximal to the first gas cell receives and passes at least a portion of the infrared light beam from the first gas cell through at least a portion of the second gas cell. At least a portion of the first gas cell and at least a portion of the second gas cell define a light path having an effective length. The system includes a means for adjusting the effective length of the light path to vary a property of the infrared light beam. Methods of making a variable effective length light path and methods of making a gas detector are also disclosed.
摘要翻译： 用于气体分析的模块化系统具有接收并使至少一部分红外光束通过至少一部分第一气室的第一气室。 设置在第一气体单元附近的第二气室容纳并使来自第一气室的至少一部分红外光束通过第二气室的至少一部分。 第一气室的至少一部分和第二气室的至少一部分限定具有有效长度的光路。 该系统包括用于调节光路的有效长度以改变红外光束的性质的装置。 还公开了制造可变有效长度光路的方法和制造气体检测器的方法。
-
公开(公告)号：US20100230591A1
公开(公告)日：2010-09-16
申请号：US12668267
申请日：2008-06-05
申请人： John Berriman , Peter Rosenthal
发明人： John Berriman , Peter Rosenthal
CPC分类号： H01J37/026 , H01J37/26 , H01J2237/0045 , H01J2237/0453 , H01J2237/1514
摘要： A transmission electron microscope has a target body position on the electron optical axis of the microscope, and an electrically conductive body off the axis of the microscope. The microscope also has an electron source for producing an axial electron beam. In use, the beam impinges upon a target body located at the target body position. The microscope further has a system for simultaneously producing a separate off-axis electron beam. In use, the off-axis electron beam impinges on the electrically conductive body causing secondary electrons to be emitted therefrom. The electrically conductive body is located such that the emitted secondary electrons impinge on the target body to neutralise positive charge which may build up on the target body.
摘要翻译： 透射电子显微镜在显微镜的电子光轴上具有目标体位置，并且离开显微镜轴线的导电体。 显微镜还具有用于产生轴向电子束的电子源。 在使用中，梁撞击位于目标体位置的目标体。 显微镜还具有同时产生单独的离轴电子束的系统。 在使用中，离轴电子束照射在导电体上，导致从其发射二次电子。 导电体被定位成使得发射的二次电子撞击目标体以中和可能在目标体上累积的正电荷。
-
公开(公告)号：US20080049214A1
公开(公告)日：2008-02-28
申请号：US11846123
申请日：2007-08-28
申请人： Alexei Maznev , Carlos Duran , Michael Gostein , Alexander Mazurenko , Gregory Merklin , Peter Rosenthal , Anthony Bonanno
发明人： Alexei Maznev , Carlos Duran , Michael Gostein , Alexander Mazurenko , Gregory Merklin , Peter Rosenthal , Anthony Bonanno
IPC分类号： G01B11/00
CPC分类号： G01B11/22 , G01B11/24 , G01N21/274 , G01N21/4788 , G01N21/956 , H01L21/67253
摘要： Structures are characterized by exposing a sample to optical radiation, measuring a spectrum associated with the exposure, detecting at least one characteristic parameter in the measured spectrum, and computing at least one structural parameter based on the at least one characteristic parameter.
摘要翻译： 结构的特征在于将样品暴露于光辐射，测量与曝光相关的光谱，检测测量光谱中的至少一个特征参数，以及基于至少一个特征参数计算至少一个结构参数。
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.025 秒)
