公开(公告)号：US07018639B1

公开(公告)日：2006-03-28

申请号：US10069799

申请日：2000-08-31

申请人： Jacinta Farn ,  Richard Strugnell ,  Jan Tennent

发明人： Jacinta Farn ,  Richard Strugnell ,  Jan Tennent

IPC分类号： A61K39/02 ,  C12P21/04 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K14/212 ,  A61K39/00 ,  A61K2039/53 ,  C07K16/40 ,  C12N9/52

摘要： The present invention relates to antigens of Moraxella, in particular, Moraxella bovis, nucleic acid sequences encoding these antigens and formulations for use in raising an immune response against Moraxella.

公开(公告)号：US20050232939A1

公开(公告)日：2005-10-20

申请号：US11021823

申请日：2004-12-22

申请人： Everett Rosey ,  Kendall King ,  Robert Good ,  Richard Strugnell

发明人： Everett Rosey ,  Kendall King ,  Robert Good ,  Richard Strugnell

IPC分类号： A61K39/00 ,  C07K14/195 ,  C07K14/205 ,  C12N1/21 ,  A61K39/02 ,  C07H21/04 ,  C12N15/74

CPC分类号： C07K14/195 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/205

摘要： The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia intracellularis or similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived from Lawsonia intracellularis, which encodes an immunogenic polypeptide that is particularly useful as an antigen in a vaccine preparation for conferring humoral immunity against Lawsonia intracellularis and related pathogens in animal hosts, wherein said polypeptide is selected from the group consisting of flhB, fliR, ntrC, glnH, motA, motB, tlyC, ytfM, and ytfN polypeptides, or a homologue, analogue or derivative of any one or more of said polypeptides. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting Lawsonia intracellularis or similar or otherwise related microorganisms.

摘要翻译： 本发明一般涉及用于治疗和/或预防由劳森氏菌或类似物或其它相关微生物引起或加剧的动物和鸟类中肠道疾病状况的治疗组合物。 特别地，本发明提供了源自细胞内劳森氏菌的新基因，其编码免疫原性多肽，其特别可用作疫苗制剂中的抗原，用于赋予动物宿主中对细胞内劳森氏菌和相关病原体的体液免疫，其中选择所述多肽 来自由flhB，fliR，ntrC，glnH，motA，motB，tlyC，ytfM和ytfN多肽组成的组，或任何一种或多种所述多肽的同源物，类似物或衍生物。 本发明还涉及用于治疗和/或预防这种肠道疾病状况的方法以及用于检测细胞内劳森氏菌或相似或相关微生物的诊断剂和方法。

公开(公告)号：US20060257417A1

公开(公告)日：2006-11-16

申请号：US11277459

申请日：2006-03-24

申请人： Jacinta Farn ,  Richard Strugnell ,  Jan Tennent

发明人： Jacinta Farn ,  Richard Strugnell ,  Jan Tennent

IPC分类号： A61K39/00 ,  A61K39/38

CPC分类号： C07K14/212 ,  A61K39/00 ,  A61K2039/53 ,  C07K16/40 ,  C12N9/52

摘要： The present invention relates to antigens of Moraxella, in particular, Moraxella bovis, nucleic acid sequences encoding these antigens and formulations for use in raising an immune response against Moraxella.

摘要翻译： 本发明涉及莫拉氏杆菌的抗原，特别是牛痘病毒，编码这些抗原的核酸序列和用于提高针对莫拉氏菌的免疫应答的制剂。