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1.发明授权3,4-di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体公开(公告)号：US07947720B2
公开(公告)日：2011-05-24
申请号：US12352781
申请日：2009-01-13
申请人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz
发明人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz
IPC分类号： C07D261/04 , C07D327/04 , A01N43/80 , A01N43/06
CPC分类号： C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译： 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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公开(公告)号：US06710037B2
公开(公告)日：2004-03-23
申请号：US10137057
申请日：2002-05-01
申请人： Lynn Wang , Richard W. Bond , Jonathan A. Pachter
发明人： Lynn Wang , Richard W. Bond , Jonathan A. Pachter
IPC分类号： A61K4800
CPC分类号： C12N15/86 , A61K38/443 , A61K48/00 , C12N2710/10343 , A61K2300/00
摘要： Novel methods of treating subjects afflicted with an androgen-dependent disorder, such as prostate cancer and benign prostatic hyperplasia are disclosed. Specifically, methods of treating androgen-dependent disorders by introducing a polypeptide or a polynucleotide encoding the polypeptide, which enhances inactivation of active androgens, are described.
摘要翻译： 公开了治疗患有雄激素依赖性疾病如前列腺癌和良性前列腺增生的受试者的新方法。 具体地，描述了通过引入增强活化雄激素失活的多肽或编码多肽的多核苷酸来治疗雄激素依赖性病症的方法。
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3.发明授权3,4-DI-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权3,4-DI取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体公开(公告)号：US07964646B2
公开(公告)日：2011-06-21
申请号：US11500739
申请日：2006-08-08
申请人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , Gaifa Lai
发明人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , Gaifa Lai
IPC分类号： C07C233/00 , A01N37/18
CPC分类号： C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译： 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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4.发明申请3,4-Di-Substituted Cyclobutene-1,2-Diones as CXC-Chemokine Receptor Ligands 审中-公开3,4-二取代的环丁烯-1,2-二酮作为CXC趋化因子受体配体公开(公告)号：US20110213029A1
公开(公告)日：2011-09-01
申请号：US13102554
申请日：2011-05-06
申请人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号： A61K31/341 , A61P11/00
CPC分类号： C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译： 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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5.发明申请3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS 有权作为CXC-CHEMOKINE受体配体的3,4-二取代的环己基-1,2-二酮公开(公告)号：US20090306079A1
公开(公告)日：2009-12-10
申请号：US12352781
申请日：2009-01-13
申请人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号： A61K31/535 , C07D401/04 , C07D295/14 , A61P37/02 , A61P9/12 , A61K31/497
CPC分类号： C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译： 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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6.发明授权3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体公开(公告)号：US07132445B2
公开(公告)日：2006-11-07
申请号：US10630258
申请日：2003-07-30
申请人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , James P. Jakway , Gaifa Lai , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , James P. Jakway , Gaifa Lai , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号： A61K31/341 , A61K31/343 , A61K31/381 , C07D333/10 , C07D33/72
CPC分类号： C07D207/335 , C07C225/20 , C07C237/30 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译： 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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