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1.3,4-DI-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译: 3,4-DI取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体公开(公告)号:US07964646B2
公开(公告)日:2011-06-21
申请号:US11500739
申请日:2006-08-08
申请人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , Gaifa Lai
发明人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , Gaifa Lai
IPC分类号: C07C233/00 , A01N37/18
CPC分类号: C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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2.3,4-di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译: 3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体公开(公告)号:US07947720B2
公开(公告)日:2011-05-24
申请号:US12352781
申请日:2009-01-13
申请人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz
发明人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz
IPC分类号: C07D261/04 , C07D327/04 , A01N43/80 , A01N43/06
CPC分类号: C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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3.3,4-Di-Substituted Cyclobutene-1,2-Diones as CXC-Chemokine Receptor Ligands 审中-公开
标题翻译: 3,4-二取代的环丁烯-1,2-二酮作为CXC趋化因子受体配体公开(公告)号:US20110213029A1
公开(公告)日:2011-09-01
申请号:US13102554
申请日:2011-05-06
申请人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号: A61K31/341 , A61P11/00
CPC分类号: C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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4.3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS 有权
标题翻译: 作为CXC-CHEMOKINE受体配体的3,4-二取代的环己基-1,2-二酮公开(公告)号:US20090306079A1
公开(公告)日:2009-12-10
申请号:US12352781
申请日:2009-01-13
申请人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号: A61K31/535 , C07D401/04 , C07D295/14 , A61P37/02 , A61P9/12 , A61K31/497
CPC分类号: C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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5.3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译: 3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体公开(公告)号:US07132445B2
公开(公告)日:2006-11-07
申请号:US10630258
申请日:2003-07-30
申请人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , James P. Jakway , Gaifa Lai , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , James P. Jakway , Gaifa Lai , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号: A61K31/341 , A61K31/343 , A61K31/381 , C07D333/10 , C07D33/72
CPC分类号: C07D207/335 , C07C225/20 , C07C237/30 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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6.3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists 失效
标题翻译: 3,4-二取代的哒嗪二酮作为CXC趋化因子受体拮抗剂公开(公告)号:US06878709B2
公开(公告)日:2005-04-12
申请号:US10335789
申请日:2003-01-02
申请人: Arthur G. Taveras , Michael Dwyer , Jianping Chao , John J. Baldwin , J. Robert Merritt , Ge Li , Jianhua Chao , Younong Yu
发明人: Arthur G. Taveras , Michael Dwyer , Jianping Chao , John J. Baldwin , J. Robert Merritt , Ge Li , Jianhua Chao , Younong Yu
IPC分类号: A61K31/50 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/00 , A61P1/02 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/28 , A61P27/02 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/06 , A61P35/00 , A61P37/02 , A61P37/04 , A61P39/00 , A61P43/00 , C07D237/22 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
CPC分类号: C07D403/12 , C07D237/22 , C07D405/12 , C07D409/12 , C07D417/12
摘要: Disclosed are compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了式(I)化合物或其药学上可接受的盐或溶剂化物。 该化合物可用于治疗趋化因子介导的疾病,例如急性和慢性炎症性疾病和癌症。
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7.3,4-di-substituted maleimide compounds as CXC chemokine receptor antagonists 失效
标题翻译: 3,4-二取代的马来酰亚胺化合物作为CXC趋化因子受体拮抗剂公开(公告)号:US06903131B2
公开(公告)日:2005-06-07
申请号:US10269775
申请日:2002-10-11
申请人: Arthur G. Taveras , Michael Dwyer , Johan A. Ferreira , Viyyoor M. Girijavallabhan , Jianping Chao , John J. Baldwin , J. Robert Merritt , Ge Li
发明人: Arthur G. Taveras , Michael Dwyer , Johan A. Ferreira , Viyyoor M. Girijavallabhan , Jianping Chao , John J. Baldwin , J. Robert Merritt , Ge Li
IPC分类号: A61K31/337 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/4155 , A61K31/4192 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/56 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/55 , A61K39/395 , A61K45/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P11/08 , A61P11/10 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/28 , A61P27/02 , A61P31/04 , A61P31/18 , A61P31/20 , A61P31/22 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/44 , C07D207/456 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
CPC分类号: C07D207/456 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要: Disclosed are compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了式(I)化合物或其药学上可接受的盐或溶剂化物。 该化合物可用于治疗趋化因子介导的疾病,例如急性和慢性炎症性疾病和癌症。
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8.3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译: 3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体公开(公告)号:US20070021494A1
公开(公告)日:2007-01-25
申请号:US11500739
申请日:2006-08-08
申请人: Arthur Taveras , Cynthia Aki , Richard Bond , Jianping Chao , Michael Dwyer , Johan Ferreira , Jianhua Chao , Younong Yu , John Baldwin , Bernd Kaiser , Ge Li , J. Merritt , Purakkattle Biju , Kingsley Nelson , Laura Rokosz , Gaifa Lai , James Jakway , Minglang Wu , Evan Hecker , Daniel Lundell , Jay Fine
发明人: Arthur Taveras , Cynthia Aki , Richard Bond , Jianping Chao , Michael Dwyer , Johan Ferreira , Jianhua Chao , Younong Yu , John Baldwin , Bernd Kaiser , Ge Li , J. Merritt , Purakkattle Biju , Kingsley Nelson , Laura Rokosz , Gaifa Lai , James Jakway , Minglang Wu , Evan Hecker , Daniel Lundell , Jay Fine
IPC分类号: A61K31/4709 , A61K31/4436 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/381 , C07D409/02 , C07D413/02 , C07D417/02
CPC分类号: C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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公开(公告)号:US06432959B1
公开(公告)日:2002-08-13
申请号:US09469465
申请日:1999-12-22
申请人: Alan B. Cooper , Ronald J. Doll , Johan A. Ferreira , Ashit Ganguly , Viyyoor M. Girijavallabhan , Arthur G. Taveras , Jianping Chao , John J. Baldwin , Chia-Yu Huang , Ge Li
发明人: Alan B. Cooper , Ronald J. Doll , Johan A. Ferreira , Ashit Ganguly , Viyyoor M. Girijavallabhan , Arthur G. Taveras , Jianping Chao , John J. Baldwin , Chia-Yu Huang , Ge Li
IPC分类号: A61K31496
CPC分类号: C07D401/14 , C07D403/12 , C07D417/14
摘要: Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
摘要翻译: 公开了新的化合物和药物组合物,其是酶的法呢基蛋白转移酶的抑制剂。 还公开了抑制Ras功能并因此抑制细胞异常生长的方法。 该方法包括将新的氨氧基酰胺化合物施用于生物系统。 特别地,该方法抑制哺乳动物如人的细胞的异常生长。
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公开(公告)号:US06372747B1
公开(公告)日:2002-04-16
申请号:US09465553
申请日:1999-12-16
申请人: Arthur G. Taveras , Ronald J. Doll , Alan B. Cooper , Johan A. Ferreira , Timothy Guzi , Dinanath F. Rane , Viyyoor M. Girijavallabhan , Cynthia J. Aki , Jianping Chao , Carmen Alvarez , Joseph M. Kelly , Tarik Lalwani , Jagdish A. Desai , James J-S Wang
发明人: Arthur G. Taveras , Ronald J. Doll , Alan B. Cooper , Johan A. Ferreira , Timothy Guzi , Dinanath F. Rane , Viyyoor M. Girijavallabhan , Cynthia J. Aki , Jianping Chao , Carmen Alvarez , Joseph M. Kelly , Tarik Lalwani , Jagdish A. Desai , James J-S Wang
IPC分类号: A61K31496
CPC分类号: C07D401/04 , C07D401/14
摘要: Disclosed are compounds of the formula: wherein R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group; R8 represents H when the alkyl chain between the amide group and the R13 imidazole group is substituted, or R8 represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R8 is H, and the alkyl chain between the amide group and the R13 imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
摘要翻译: 公开了下式的化合物:其中R 13表示咪唑环; R14表示氨基甲酸酯,脲,酰胺或磺酰胺基; 当酰胺基和R 13咪唑基之间的烷基链被取代时,R8表示H,或R8表示芳基烷基,杂芳基烷基或环烷基等取代基; 并且其余的取代基如本文所定义。 还公开了其中R 8为H,酰胺基和R 13咪唑基之间的烷基链未被取代的化合物。 还公开了使用所公开的化合物治疗癌症的方法和抑制法呢基蛋白转移酶的方法。
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