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1.3,4-Di-Substituted Cyclobutene-1,2-Diones as CXC-Chemokine Receptor Ligands 审中-公开
标题翻译: 3,4-二取代的环丁烯-1,2-二酮作为CXC趋化因子受体配体公开(公告)号:US20110213029A1
公开(公告)日:2011-09-01
申请号:US13102554
申请日:2011-05-06
申请人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号: A61K31/341 , A61P11/00
CPC分类号: C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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2.3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS 有权
标题翻译: 作为CXC-CHEMOKINE受体配体的3,4-二取代的环己基-1,2-二酮公开(公告)号:US20090306079A1
公开(公告)日:2009-12-10
申请号:US12352781
申请日:2009-01-13
申请人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号: A61K31/535 , C07D401/04 , C07D295/14 , A61P37/02 , A61P9/12 , A61K31/497
CPC分类号: C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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3.3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译: 3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体公开(公告)号:US07132445B2
公开(公告)日:2006-11-07
申请号:US10630258
申请日:2003-07-30
申请人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , James P. Jakway , Gaifa Lai , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , James P. Jakway , Gaifa Lai , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号: A61K31/341 , A61K31/343 , A61K31/381 , C07D333/10 , C07D33/72
CPC分类号: C07D207/335 , C07C225/20 , C07C237/30 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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公开(公告)号:US20110318349A1
公开(公告)日:2011-12-29
申请号:US13167323
申请日:2011-06-23
IPC分类号: A61K39/395 , C12N9/96 , C07H21/00 , C12N15/63 , C12P21/00 , A61P35/00 , C12N5/10 , C12N1/21 , C12N1/15 , C12N1/00 , A61P29/00 , C07K16/24 , G01N33/566
CPC分类号: C07K16/2875 , C07K16/241 , C07K16/468 , C07K2317/31 , C07K2317/64
摘要: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号:US5767120A
公开(公告)日:1998-06-16
申请号:US479418
申请日:1995-06-06
申请人: Pauline C. Ting , Daniel M. Solomon , Richard J. Friary , John J. Piwinski , Joe F. Lee , Vera A. Seidl , James P. Jakway
发明人: Pauline C. Ting , Daniel M. Solomon , Richard J. Friary , John J. Piwinski , Joe F. Lee , Vera A. Seidl , James P. Jakway
IPC分类号: C07D295/02 , A61K31/125 , A61K31/135 , A61K31/18 , A61K31/195 , A61K31/335 , A61K31/40 , A61K31/4025 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/44 , A61K31/443 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/08 , A61P43/00 , C07C33/38 , C07C45/44 , C07C47/235 , C07C47/453 , C07C69/608 , C07C69/618 , C07C211/26 , C07C211/32 , C07C215/42 , C07C217/52 , C07C229/14 , C07C233/05 , C07C233/18 , C07C233/73 , C07C251/40 , C07C271/10 , C07C271/12 , C07C271/16 , C07C311/03 , C07C311/04 , C07C311/17 , C07D207/16 , C07D209/08 , C07D209/44 , C07D209/48 , C07D213/89 , C07D221/16 , C07D261/02 , C07D295/03 , C07D295/084 , C07D313/12 , C07D405/06 , C07D401/00 , A61K31/495 , C07D221/00
CPC分类号: C07D295/03 , A61K31/00 , A61K31/135 , C07C211/32 , C07C217/52 , C07C229/14 , C07C233/18 , C07C233/73 , C07C251/40 , C07C271/12 , C07C271/16 , C07C311/04 , C07C311/17 , C07D221/16 , C07D295/092 , C07D313/12 , C07C2101/02 , C07C2103/32
摘要: Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R.sup.3 is alkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl, cycloalkyl, acyloxymethyl, alkoxy, alkoxymethyl, or alkyl substituted with cycloalkyl;R.sup.4 is H, alkyl, alkenyl, alkoxy, or --OH. Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor-.alpha. and methods for treating septic shock, inflammation, or allergic disease by administering a compound of Formula I.
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