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    Method and apparatus of uniform gas-phase molecular matrix deposition for imaging mass spectrometry
    1.
    发明授权
    Method and apparatus of uniform gas-phase molecular matrix deposition for imaging mass spectrometry 有权
    用于成像质谱的均匀气相分子基质沉积的方法和装置

    公开(公告)号：US07880139B2

    公开(公告)日：2011-02-01

    申请号：US12154912

    申请日：2008-05-28

    申请人： Yanfeng Chen ,  M. Cameron Sullards ,  Thomas M. Orlando ,  Joseph A. Hankin ,  Robert C. Murphy ,  Robert M. Barkley

    发明人： Yanfeng Chen ,  M. Cameron Sullards ,  Thomas M. Orlando ,  Joseph A. Hankin ,  Robert C. Murphy ,  Robert M. Barkley

    IPC分类号： H01J49/04

    CPC分类号： H01J49/0004 ,  G01N1/2813 ,  H01J49/0418

    摘要： Disclosed are apparatus and methods for depositing solvent-free molecules on surfaces of samples, with particular application to imaging mass spectrometry. A vacuum chamber is configured to have controllable matrix translation apparatus for controlling the position of one or more solvent-free matrices within the chamber. Sublimation apparatus is used to sublimate molecules from the solid phase matrices. One or more samples are placed separately from the solvent-free matrices within the chamber. Condensation apparatus individually cools the samples to deposit sublimated molecules on the samples. Controllable sample translation apparatus is used to control the position of the samples within the chamber. Rotatable sample holding apparatus may be used to hold and move the samples to allow deposition of molecules on multiple samples at substantially the same time. Rotatable matrix holding apparatus may also be used to hold and move a plurality of matrices to create a homogenous mixture of molecules that are deposited onto one or more samples. As surface characterization system may be used to monitor deposition of the molecules to determine their thickness and roughness. A computer may be configured to control the matrix translation apparatus, the sublimation apparatus, the condensation apparatus, and the sample translation apparatus to provide for automated deposition of solvent-free molecules on the samples.

    摘要翻译： 公开了用于在样品表面上沉积无溶剂分子的装置和方法，特别适用于成像质谱法。 真空室被配置为具有用于控制腔室内的一种或多种无溶剂基质的位置的可控矩阵平移装置。 升华装置用于升华固相基质中的分子。 将一个或多个样品与腔室内的无溶剂基质分开放置。 冷凝装置分别冷却样品以将升华的分子沉积在样品上。 可控样品转换装置用于控制室内样品的位置。 可旋转的样品保持装置可用于保持和移动样品，以允许分子在基本上同时沉积在多个样品上。 可旋转矩阵保持装置还可以用于保持和移动多个矩阵以产生沉积在一个或多个样本上的分子的均匀混合物。 由于表面表征系统可用于监测分子的沉积以确定其厚度和粗糙度。 计算机可以被配置为控制矩阵翻译装置，升华装置，冷凝装置和样品翻译装置，以提供样品上无溶剂分子的自动沉积。

    Method and apparatus of uniform gas-phase molecular matrix deposition for imaging mass spectrometry
    2.
    发明申请
    Method and apparatus of uniform gas-phase molecular matrix deposition for imaging mass spectrometry 有权
    用于成像质谱的均匀气相分子基质沉积的方法和装置

    公开(公告)号：US20100090099A1

    公开(公告)日：2010-04-15

    申请号：US12154912

    申请日：2008-05-28

    申请人： Yanfeng Chen ,  M. Cameron Sullards ,  Thomas M. Orlando ,  Joseph A. Hankin ,  Robert C. Murphy ,  Robert M. Barkley

    发明人： Yanfeng Chen ,  M. Cameron Sullards ,  Thomas M. Orlando ,  Joseph A. Hankin ,  Robert C. Murphy ,  Robert M. Barkley

    IPC分类号： H01J49/00

    CPC分类号： H01J49/0004 ,  G01N1/2813 ,  H01J49/0418

    摘要： Disclosed are apparatus and methods for depositing solvent-free molecules on surfaces of samples, with particular application to imaging mass spectrometry. A vacuum chamber is configured to have controllable matrix translation apparatus for controlling the position of one or more solvent-free matrices within the chamber. Sublimation apparatus is used to sublimate molecules from the solid phase matrices. One or more samples are placed separately from the solvent-free matrices within the chamber. Condensation apparatus individually cools the samples to deposit sublimated molecules on the samples. Controllable sample translation apparatus is used to control the position of the samples within the chamber. Rotatable sample holding apparatus may be used to hold and move the samples to allow deposition of molecules on multiple samples at substantially the same time. Rotatable matrix holding apparatus may also be used to hold and move a plurality of matrices to create a homogenous mixture of molecules that are deposited onto one or more samples. As surface characterization system may be used to monitor deposition of the molecules to determine their thickness and roughness. A computer may be configured to control the matrix translation apparatus, the sublimation apparatus, the condensation apparatus, and the sample translation apparatus to provide for automated deposition of solvent-free molecules on the samples.

    摘要翻译： 公开了用于在样品表面上沉积无溶剂分子的装置和方法，特别适用于成像质谱法。 真空室被配置为具有用于控制腔室内的一种或多种无溶剂基质的位置的可控矩阵平移装置。 升华装置用于升华固相基质中的分子。 将一个或多个样品与腔室内的无溶剂基质分开放置。 冷凝装置分别冷却样品以将升华的分子沉积在样品上。 可控样品转换装置用于控制室内样品的位置。 可旋转的样品保持装置可用于保持和移动样品，以允许分子在基本上同时沉积在多个样品上。 可旋转矩阵保持装置还可以用于保持和移动多个矩阵以产生沉积在一个或多个样本上的分子的均匀混合物。 由于表面表征系统可用于监测分子的沉积以确定其厚度和粗糙度。 计算机可以被配置为控制矩阵翻译装置，升华装置，冷凝装置和样品翻译装置，以提供样品上无溶剂分子的自动沉积。

    Bulk container formed from blank having T-shaped slots separating closure flaps
    3.
    发明授权
    Bulk container formed from blank having T-shaped slots separating closure flaps 失效
    由具有T形槽的坯件形成的散装容器分隔闭合襟翼

    公开(公告)号：US6024279A

    公开(公告)日：2000-02-15

    申请号：US962243

    申请日：1997-10-30

    申请人： Gregg D. McGary ,  Robert C. Murphy

    发明人： Gregg D. McGary ,  Robert C. Murphy

    IPC分类号： B65D5/10 ,  B65D5/42

    CPC分类号： B65D5/10 ,  B65D5/4266 ,  Y10S229/92 ,  Y10S229/939

    摘要： A bulk container is formed from a blank of corrugated sheet material having wall fold lines demarcating end wall panels and side wall panels, and flap fold lines demarcating top and bottom closure flaps. A T-shaped slot in the blank separates adjacent closure flaps from one another. A first portion of each slot extends inwardly from the free outer edges of the closure flaps and terminates at a second portion which extends substantially perpendicular to the first portion. The first portion of each slot is substantially aligned with a corresponding wall fold line. The second portion of each slot extends substantially colinearly with a flap fold line. The slots reduce binding and bunching of the thick multilayer reinforced walls found in conventional bulk container constructions, and at the same time avoid formation of through-holes at the corners of the container.

    摘要翻译： 散装容器由波纹板材的坯件形成，其具有划定端壁板和侧壁板的折叠线，以及划分顶部和底部封闭襟翼的折翼折线。 空白处的T形槽将相邻的封闭襟翼彼此分开。 每个槽的第一部分从闭合翼片的自由外边缘向内延伸，并终止于基本上垂直于第一部分延伸的第二部分。 每个槽的第一部分基本上与相应的壁折叠线对准。 每个槽的第二部分基本上与翼片折叠线共线延伸。 狭槽减少了在常规散装容器结构中发现的厚多层增强壁的结合和聚束，并且同时避免在容器的角落处形成通孔。

    System for characterizing semiconductor materials and photovoltaic devices through calibration
    4.
    发明授权
    System for characterizing semiconductor materials and photovoltaic devices through calibration 失效
    通过校准表征半导体材料和光伏器件的系统

    公开(公告)号：US5757474A

    公开(公告)日：1998-05-26

    申请号：US496061

    申请日：1995-06-28

    申请人： Bhushan L. Sopori ,  Larry C. Allen ,  Craig Marshall ,  Robert C. Murphy ,  Todd Marshall

    发明人： Bhushan L. Sopori ,  Larry C. Allen ,  Craig Marshall ,  Robert C. Murphy ,  Todd Marshall

    IPC分类号： G01N21/95 ,  G01N21/88

    CPC分类号： G01N21/9505 ,  G01N21/9501

    摘要： A method and apparatus for measuring characteristics of a piece of material, typically semiconductor materials including photovoltaic devices. The characteristics may include dislocation defect density, grain boundaries, reflectance, external LBIC, internal LBIC, and minority carrier diffusion length. The apparatus includes a light source, an integrating sphere, and a detector communicating with a computer. The measurement or calculation of the characteristics is calibrated to provide accurate, absolute values. The calibration is performed by substituting a standard sample for the piece of material, the sample having a known quantity of one or more of the relevant characteristics. The quantity measured by the system of the relevant characteristic is compared to the known quantity and a calibration constant is created thereby.

    摘要翻译： 一种用于测量一块材料（通常包括光伏器件的半导体材料）的特性的方法和装置。 特征可能包括位错缺陷密度，晶界，反射率，外部LBIC，内部LBIC和少数载流子扩散长度。 该装置包括光源，积分球和与计算机通信的检测器。 校准特征的测量或计算以提供准确的绝对值。 通过用标准样品代替材料进行校准，样品具有已知量的一种或多种相关特征。 将相关特性的系统测量的量与已知量进行比较，由此产生校准常数。

    Use Of Flap Inhibitors To Reduce Neuroinflammation Mediated Injury In The Central Nervous System
    6.
    发明申请
    Use Of Flap Inhibitors To Reduce Neuroinflammation Mediated Injury In The Central Nervous System 审中-公开
    使用襟翼抑制剂减少神经炎症介导的中枢神经系统损伤

    公开(公告)号：US20150216854A1

    公开(公告)日：2015-08-06

    申请号：US14613658

    申请日：2015-02-04

    申请人： Kim A. Heidenreich ,  Robert C. Murphy

    发明人： Kim A. Heidenreich ,  Robert C. Murphy

    IPC分类号： A61K31/4709 ,  A61K31/404

    CPC分类号： A61K31/4709 ,  A61K9/0043 ,  A61K31/404 ,  A61K31/405 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides methods of attenuating or preventing brain injury mediated damage in the central nervous system by attenuating or preventing leukotriene-mediated events following a brain injury or long-term neuroinflammation after brain injury, in Alzheimer's disease, multiple sclerosis, stroke, and post-traumatic stress disorder. The methods comprise administering at least one 5-lipoxygenase activating protein (FLAP) inhibitor either before or after the brain injury. The method finds use in the treatment of traumatic brain injury (TBI), stroke, multiple sclerosis, Alzheimer's disease, post-traumatic stress disorder and other brain injuries associated with production of leukotrienes in the central nervous system. Preferably the FLAP inhibitor is administered intranasally and preferably for certain high risk individuals prophylactically prior to any potential brain injury event.

    摘要翻译： 本发明提供了减轻或预防脑损伤介导的中枢神经系统损伤的方法，其通过减弱或预防脑损伤或脑损伤后长期神经炎症，阿尔茨海默病，多发性硬化，中风和后期中的白细胞三烯介导的事件 创伤性应激障碍。 所述方法包括在脑损伤之前或之后施用至少一种5-脂氧合酶活化蛋白（FLAP）抑制剂。 该方法可用于治疗创伤性脑损伤（TBI），中风，多发性硬化，阿尔茨海默氏病，创伤后应激障碍以及与中枢神经系统白细胞三烯生成相关的其他脑损伤。 优选地，在任何潜在的脑损伤事件之前，FLAP抑制剂在鼻内和优选地对某些高风险个体进行预防性施用。