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1.发明申请Device and Method for Electroporation Based Treatment of Stenosis of a Tubular Body Part 审中-公开用于基于电穿孔的管状体部分狭窄的装置和方法公开(公告)号：US20130184702A1
公开(公告)日：2013-07-18
申请号：US13550307
申请日：2012-07-16
IPC分类号： A61B18/00
CPC分类号： A61B18/00 , A61B18/1492 , A61B2018/0022 , A61B2018/00613 , A61B2018/00767 , A61B2018/00875 , A61B2018/1467 , A61B2090/3925 , A61B2090/3966
摘要： The present invention relates to medical devices and methods for treating a lesion such as a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodiments of the present invention provide a balloon catheter type NTIRE device for treating a target lesion comprising a plurality of electrodes positioned along the balloon that are electrically independent from each other so as to be individually selectable in order to more precisely treat an asymmetrical lesion in which the lesion extends only partially around the vessel.
摘要翻译： 本发明涉及使用非热不可逆电穿孔（NTIRE）治疗病变如血管狭窄的医疗装置和方法。 本发明的实施例提供了一种用于治疗靶病变的球囊导管型NTIRE装置，其包括沿气囊定位的多个电极，其彼此电独立，以便可单独选择，以便更精确地治疗不对称损伤，其中 病变部分仅在血管周围延伸。
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公开(公告)号：US10702326B2
公开(公告)日：2020-07-07
申请号：US13550307
申请日：2012-07-16
摘要： The present invention relates to medical devices and methods for treating a lesion such as a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodiments of the present invention provide a balloon catheter type NTIRE device for treating a target lesion comprising a plurality of electrodes positioned along the balloon that are electrically independent from each other so as to be individually selectable in order to more precisely treat an asymmetrical lesion in which the lesion extends only partially around the vessel.
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公开(公告)号：US08992517B2
公开(公告)日：2015-03-31
申请号：US12491151
申请日：2009-06-24
CPC分类号： A61B18/1477 , A61B18/1206 , A61B2018/00446 , A61B2018/00613 , A61N1/05 , A61N1/327 , C12N13/00
摘要： The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
摘要翻译： 本发明提供用于体内治疗细胞增殖性疾病的方法，装置和系统。 本发明可用于治疗诸如脑肿瘤的实体瘤。 该方法依赖于非热不可逆电穿孔（IRE）在治疗的肿瘤中引起细胞死亡。
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4.发明申请IRREVERSIBLE ELECTROPORATION USING TISSUE VASCULATURE TO TREAT ABERRANT CELL MASSES OR CREATE TISSUE SCAFFOLDS 有权不可逆电气使用组织血管来治疗细胞质量或产生组织病变公开(公告)号：US20130253415A1
公开(公告)日：2013-09-26
申请号：US13989175
申请日：2011-11-23
CPC分类号： A61B18/14 , A61B18/1492 , A61B2018/00613 , A61B2018/1472 , A61B2218/002 , A61K48/0075 , A61M5/00 , A61N1/327
摘要： The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
摘要翻译： 本发明涉及疾病和病症的医疗领域以及生物医学工程领域。 本发明的实施方案涉及通过器官脉管系统递送不可逆电穿孔（IRE）以治疗深入组织或器官内的肿瘤，或者使现有动物组织脱细胞从而使现有的脉管系统完整地产生支架。 特别地，提供了在体内施用非热不可逆电穿孔（IRE）的方法用于治疗位于血管化组织和器官中的肿瘤。 本发明的实施方案进一步提供了使用IRE离体产生的来自天然来源的支架和组织，以去除细胞碎片，最大限度地获得细胞结合潜能，并使异物免疫应答最小化。 工程组织可用于治疗受试者的方法，例如需要组织置换或增生的方法。
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公开(公告)号：US20110106221A1
公开(公告)日：2011-05-05
申请号：US12906923
申请日：2010-10-18
申请人： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
发明人： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
CPC分类号： C12N13/00 , A61B34/10 , A61B2018/00613 , A61B2034/104 , A61B2034/105 , A61N1/0412 , G16H50/50
摘要： The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
摘要翻译： 本发明提供了用于基于电穿孔的疗法（EBT）的系统，方法和装置。 实施例提供了通过从组织拍摄的图像对目标组织进行3D重建的数值模拟得出的患者特异性治疗方案，并且可选地考虑物理约束或动态组织属性中的一种或多种。 本发明还涉及用于递送用于不可逆电穿孔的双极电脉冲的系统，方法和装置，其显示对EBT诱导的递送至组织的过量电荷通常相关的组织的减少或不损伤。
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公开(公告)号：US09867652B2
公开(公告)日：2018-01-16
申请号：US13989175
申请日：2011-11-23
CPC分类号： A61B18/14 , A61B18/1492 , A61B2018/00613 , A61B2018/1472 , A61B2218/002 , A61K48/0075 , A61M5/00 , A61N1/327
摘要： The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
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公开(公告)号：US20100030211A1
公开(公告)日：2010-02-04
申请号：US12491151
申请日：2009-06-24
CPC分类号： A61B18/1477 , A61B18/1206 , A61B2018/00446 , A61B2018/00613 , A61N1/05 , A61N1/327 , C12N13/00
摘要： The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
摘要翻译： 本发明提供用于体内治疗细胞增殖性疾病的方法，装置和系统。 本发明可用于治疗诸如脑肿瘤的实体瘤。 该方法依赖于非热不可逆电穿孔（IRE）在治疗的肿瘤中引起细胞死亡。
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8.发明申请SYSTEM AND METHOD FOR INTERACTIVELY PLANNING AND CONTROLLING A TREATMENT OF A PATIENT WITH A MEDICAL TREATMENT DEVICE 审中-公开用于交互式计划和控制用医疗治疗装置治疗患者的系统和方法公开(公告)号：US20100249771A1
公开(公告)日：2010-09-30
申请号：US12751854
申请日：2010-03-31
申请人： Robert M. Pearson , James G. Lovewell , David Warden , David Lee Morrison , Tony R. Sarno , Hy Truong Lai , William C. Hamilton, JR. , Rafael Vidal Davalos , Robert E. Neal, II
发明人： Robert M. Pearson , James G. Lovewell , David Warden , David Lee Morrison , Tony R. Sarno , Hy Truong Lai , William C. Hamilton, JR. , Rafael Vidal Davalos , Robert E. Neal, II
IPC分类号： A61B18/12
CPC分类号： A61B18/1206 , A61B18/148 , A61B34/10 , A61B34/20 , A61B2018/00613 , A61B2018/00684 , A61B2018/00702 , A61B2018/00839 , A61B2034/104 , A61B2034/2063
摘要： A system and method for interactively planning and controlling a treatment of a patient for a medical treatment device are provided. The system includes a memory; a processor coupled to the memory; and a treatment control module stored in the memory and executable by the processor. The treatment control module graphically displays in real time a continuously changing treatment region defined by the electrodes as a user moves at least one of the electrodes. This allows the user to more effectively plan and treat a target region.
摘要翻译： 提供了用于交互地规划和控制用于医疗处理装置的患者的治疗的系统和方法。 该系统包括一个内存; 耦合到存储器的处理器; 以及存储在存储器中并由处理器执行的处理控制模块。 当用户移动至少一个电极时，治疗控制模块实时图形地显示由电极限定的连续变化的治疗区域。 这允许用户更有效地规划和处理目标区域。
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公开(公告)号：US09198733B2
公开(公告)日：2015-12-01
申请号：US12906923
申请日：2010-10-18
申请人： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
发明人： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
CPC分类号： C12N13/00 , A61B34/10 , A61B2018/00613 , A61B2034/104 , A61B2034/105 , A61N1/0412 , G16H50/50
摘要： The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
摘要翻译： 本发明提供了用于基于电穿孔的疗法（EBT）的系统，方法和装置。 实施例提供了通过从组织拍摄的图像对目标组织进行3D重建的数值模拟得出的患者特异性治疗方案，并且可选地考虑物理约束或动态组织属性中的一种或多种。 本发明还涉及用于递送用于不可逆电穿孔的双极电脉冲的系统，方法和装置，其显示对EBT诱导的递送至组织的过量电荷通常相关的组织的减少或不损伤。
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10.发明申请SYSTEM AND METHOD FOR ESTIMATING A TREATMENT REGION FOR A MEDICAL TREATMENT DEVICE 审中-公开用于估计医疗处理设备的治疗区域的系统和方法公开(公告)号：US20100250209A1
公开(公告)日：2010-09-30
申请号：US12751826
申请日：2010-03-31
申请人： Robert M. Pearson , James G. Lovewell , David Warden , David Lee Morrison , Tony R. Sarno , Hy Truong Lai , William C. Hamilton, JR. , Rafael Vidal Davalos , Robert E. Neal, II
发明人： Robert M. Pearson , James G. Lovewell , David Warden , David Lee Morrison , Tony R. Sarno , Hy Truong Lai , William C. Hamilton, JR. , Rafael Vidal Davalos , Robert E. Neal, II
CPC分类号： A61B18/1206 , A61B18/148 , A61B34/10 , A61B34/20 , A61B2018/00613 , A61B2018/00684 , A61B2018/00702 , A61B2018/00839 , A61B2034/104 , A61B2034/2063
摘要： A medical system and method for estimating a treatment region for a medical treatment device is provided. The system includes a memory; a processor coupled to the memory; and a treatment control module stored in the memory and executable by the processor. The treatment control module generates an estimated treatment region which is an estimate of a treatment region which would have been derived as a result of a numerical model analysis such as a finite element analysis. Advantageously, the estimated treatment region is generated using a fraction of the time it takes to generate the region using the numerical model analysis.
摘要翻译： 提供了一种用于估计医疗处理装置的治疗区域的医疗系统和方法。 该系统包括一个内存; 耦合到存储器的处理器; 以及存储在存储器中并由处理器执行的处理控制模块。 处理控制模块生成作为由诸如有限元分析之类的数值模型分析的结果而导出的处理区域的估计的估计处理区域。 有利地，使用数值模型分析使用生成区域所花费的时间的一小部分来生成估计的处理区域。
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