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公开(公告)号：US5916873A
公开(公告)日：1999-06-29
申请号：US53848
申请日：1998-04-01
摘要： The present invention is directed to teicoplanin derivatives of the following general formula, wherein R.sup.1 and R.sup.2 are as defined in the specification. ##STR1## These derivatives are useful as antibiotics for the control of gram-positive bacteria.
摘要翻译： 本发明涉及以下通式的替考拉宁衍生物，其中R1和R2如说明书中所定义。 这些衍生物可用作控制革兰氏阳性细菌的抗生素。
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公开(公告)号：US5919756A
公开(公告)日：1999-07-06
申请号：US847069
申请日：1997-05-01
摘要： The present invention is directed to amides of antibiotic A82846B (also known as chloroorienticin A), and of N.sup.4 -derivatives of A82846B. The present amide compounds are useful as antibacterials, especially for the control of gram positive bacteria; the compounds are particularly useful for the control of resistant bacterial strains, such as vancomycin-resistant-enterococci ("VRE").
摘要翻译： 本发明涉及抗生素A82846B（也称为氯霉素A）和A82846B的N4衍生物的酰胺。 本发明的酰胺化合物可用作抗细菌剂，特别是用于控制革兰氏阳性细菌; 该化合物特别可用于控制抗性细菌菌株，例如耐万古霉素 - 肠球菌（“VRE”）。
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公开(公告)号：US5936074A
公开(公告)日：1999-08-10
申请号：US53668
申请日：1998-04-01
申请人： Barbara Shreve Briggs , Robin David Grey Cooper , Adam Joseph Kreuzman , Milton Joseph Zmijewski, Jr.
发明人： Barbara Shreve Briggs , Robin David Grey Cooper , Adam Joseph Kreuzman , Milton Joseph Zmijewski, Jr.
摘要： The present invention is directed to deacyl teicoplanin, and to a process for preparing deacyl teicoplanin by reacting teicoplanin with ECB deacylase. Deacyl teicoplanin can be alkylated to produce compounds useful for their antibacterial activity.
摘要翻译： 本发明涉及脱酰替考拉宁，以及通过将替考拉宁与ECB脱酰酶反应制备脱酰基替考拉宁的方法。 可以将脱酰基替考拉宁烷基化以产生可用于其抗菌活性的化合物。
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