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公开(公告)号:US06958145B2
公开(公告)日:2005-10-25
申请号:US10312155
申请日:2001-06-28
Applicant: Naresh Kumar , Roger Wayne Read
Inventor: Naresh Kumar , Roger Wayne Read
IPC: A61K31/365 , A61P31/04 , A61P31/10 , C07B61/00 , C07C59/21 , C07C59/347 , C07D307/58 , C07D307/60 , C08F34/00 , C08F224/00 , C07D307/33
CPC classification number: C07D307/58 , C07C59/347 , C07D307/60 , C08F224/00
Abstract: A method for the preparation of a compound of formula (II) wherein R1 and R2 are independently H, alkyl, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more hetero atoms, straight chain or branched chain, hydrophilic, hydrophobic or fluorophilic; R3, R4, R5 and R6 are independently or all hydrogen or halogen; provided that at least two of the R3, R4, R5 and R6 are halogens.
Abstract translation: 制备式(II)化合物的方法,其中R 1和R 2独立地是H,烷基,烷氧基,氧代烷基,烯基,芳基或芳基烷基,无论是未取代的 或取代的,任选被一个或多个杂原子间隔的直链或支链,亲水的,疏水的或富含荧光的; R 3,R 4,R 5和R 6是独立地或全部是氢或卤素; 条件是R 3,R 4,R 5和R 6中的至少两个是卤素。