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公开(公告)号：US06595208B1
公开(公告)日：2003-07-22
申请号：US09463264
申请日：2000-04-11
IPC分类号： A61M1100
CPC分类号： B05B5/002 , B05B1/042 , B05B5/0255
摘要： A supply pipe (33) supplies a liquid to a comminution site (40) at which the liquid is subjected to an electric field so as to produce charged comminuted material. An electrical discharge electrode (5) produces ions to at least partially electrically discharge the comminuted material. A further electrode (60) spaced from the comminution site (40) by the electrical discharge electrode (50) electrically attracts ions produced by the electrical discharge electrode (50) away from the comminution site (40) until sufficient space charge is built up to divert the ions towards the charged comminuted material to enable the ions at least partially to discharge the comminuted material.
摘要翻译： 供给管（33）向液体经受电场的粉碎部位（40）供给液体，生成带电粉碎材料。 放电电极（5）产生离子以至少部分地电动排出粉碎的材料。 通过放电电极（50）与粉碎部位（40）间隔开的另一电极（60）电吸引由放电电极（50）产生的离子远离粉碎部位（40），直到建立足够的空间电荷 将离子转移到带电的粉碎材料上，以使离子至少部分地排出粉碎的材料。
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公开(公告)号：US5915377A
公开(公告)日：1999-06-29
申请号：US750492
申请日：1997-01-24
申请人： Ronald Alan Coffee
发明人： Ronald Alan Coffee
CPC分类号： B05B5/002 , A61M15/02 , B05B5/003 , B05B5/0255 , B05B5/0531
摘要： A device for comminuting a liquid, which produces at least two sprays of droplets formed by electrohydrodynamic comminution, the device being arranged so that in use sprays of opposing polarity are formed which are substantially admixed after formation, so as to provide a comminution having a residual electrical charge.
摘要翻译： PCT No.PCT / EP95 / 02001 Sec。 371日期1997年1月24日 102（e）1997年1月24日PCT PCT 1995年5月25日PCT公布。 公开号WO95 / 32807 日期1995年12月7日一种用于粉碎液体的装置，其产生至少两次通过电动力粉碎形成的液滴喷雾，该装置被布置成使用形成相反极性的喷雾，其在形成之后基本上混合，以便提供 具有残留电荷的粉碎物。
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公开(公告)号：US5655517A
公开(公告)日：1997-08-12
申请号：US457077
申请日：1995-06-01
申请人： Ronald Alan Coffee
发明人： Ronald Alan Coffee
CPC分类号： B05B5/0255 , A61M15/00
摘要： A device for dispensing a comminuted liquid to the upper respiratory tract, which comprises an electrohydrodynamic comminution means and a means for supplying a liquid to the comminution means. And a device for comminuting a liquid, the comminution site sit of which is provided by fibres projecting from an end surface or edge, the edge or surface being composed substantially of fibres.
摘要翻译： 一种用于将粉碎液体分配到上呼吸道的装置，其包括电动液体粉碎装置和用于将液体供应到粉碎装置的装置。 还有一种用于粉碎液体的装置，其粉碎部位由从端表面或边缘突出的纤维提供，所述边缘或表面基本上由纤维组成。
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公开(公告)号：US07883032B2
公开(公告)日：2011-02-08
申请号：US10240356
申请日：2001-04-03
IPC分类号： B05B5/00
CPC分类号： A61M15/00 , A61M11/00 , A61M11/001 , A61M15/02 , A61M15/08 , B05B5/0255 , B05B5/1691
摘要： Methods are described of delivering biological material, which methods include the steps of providing a liquid formulation containing the biological material, supplying the liquid formulation to an outlet and subjecting liquid issuing from the outlet to an electrical field thereby causing electrohydrodynamic processing of the liquid without denaturing the biological material. In one example, the liquid formulation is provided by removing salts from a formulation containing biological material that does not denature in alcohol and then adding an alcohol to the formulation before supplying the liquid formulation to the outlet. An acid may be added to the liquid formulation before supplying the liquid formulation to the outlet.
摘要翻译： 描述了递送生物材料的方法，该方法包括以下步骤：提供含有生物材料的液体制剂，将液体制剂供应到出口并使从出口发出的液体经受电场，从而引起液体的电流动力学处理而不变性 生物材料。 在一个实例中，通过从含有在醇中不变性的生物材料的制剂中除去盐，然后在将液体制剂供应到出口之前向制剂中加入醇来提供液体制剂。 在将液体制剂供应到出口之前，可以向液体制剂中加入酸。
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公开(公告)号：US20100286591A1
公开(公告)日：2010-11-11
申请号：US12823205
申请日：2010-06-25
申请人： Ronald Alan Coffee
发明人： Ronald Alan Coffee
CPC分类号： A61F13/00063 , A61F13/069 , A61F13/36 , A61F2013/0011 , A61F2013/00157 , A61F2013/00519 , A61F2013/0091 , A61F2013/00914 , A61F2013/00923 , A61F2013/00927 , A61M15/0003 , A61M15/0011 , A61M15/02 , B05B1/044 , B05B1/06 , B05B1/14 , B05B5/0255 , B05B5/1691 , B05B7/061 , B05B12/1472 , D01D5/0084 , D01F1/10
摘要： A dispensing device and method for forming a least partially solid or gel-like material from a liquid. At least one liquid issuing from an outlet is subjected to an electric field causing the liquid to form at least one electrically charged jet which, after formation, forms a fiber (F) or breaks up into fiber fragments (FF) or particles (D). The thus formed at least partially solid or gel-like material may be directly deposited, by virtue of the energy in the electrical field, onto a surface area, for example an area of skin enabling, for example, formation of a dressing for a wound or burn which is of high specific area and extremely absorbent. A biologically active ingredient such as a pharmaceutical ingredient or biological matter such as DNA may be incorporated into the fibers (F), fragments (FF) or particles (D). Fibrils, particles or microcapsules incorporating a biologically active ingredient may be supplied for oral or nasal administration to an animal such as a human being.
摘要翻译： 一种用于从液体形成至少部分固体或凝胶状材料的分配装置和方法。 从出口排出的至少一种液体经受电场，导致液体形成至少一个带电的射流，其在形成后形成纤维（F）或分解成纤维碎片（FF）或颗粒（D） 。 由此形成的至少部分固体或凝胶状材料可以通过电场中的能量直接沉积到表面区域上，例如能够形成伤口敷料的皮肤区域 或具有高比表面积和极度吸收性的燃烧。 生物活性成分如药物成分或生物物质如DNA可以并入纤维（F），碎片（FF）或颗粒（D）中。 可以向动物如人提供包含生物活性成分的原纤维，颗粒或微胶囊用于口服或鼻腔给药。
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公开(公告)号：US07193124B2
公开(公告)日：2007-03-20
申请号：US09758716
申请日：2001-01-11
申请人： Ronald Alan Coffee
发明人： Ronald Alan Coffee
IPC分类号： A61F13/00
CPC分类号： A61F13/00995 , A61F13/00085 , A61F13/36 , A61F2013/0011 , A61F2013/00157 , A61F2013/00519 , A61F2013/0091 , A61F2013/00914 , A61F2013/00927 , A61M15/0003 , A61M15/0011 , A61M15/02 , B05B1/044 , B05B1/06 , B05B1/14 , B05B5/0255 , B05B5/1691 , B05B7/061 , B05B12/1472 , D01D5/0084 , D01F1/10
摘要： A dispensing device and method for forming a least partially solid or gel-like material from a liquid. At least one liquid issuing from an outlet is subjected to an electric field causing the liquid to form at least one electrically charged jet which, after formation, forms a fiber (F) or breaks up into fiber fragments (FF) or particles (D). The thus formed at least partially solid or gel-like material may be directly deposited, by virtue of the energy in the electrical field, onto a surface area, for example an area of skin enabling, for example, formation of a dressing for a wound or burn which is of high specific area and extremely absorbent. A biologically active ingredient such as a pharmaceutical ingredient or biological matter such as DNA may be incorporated into the fibers (F), fragments (FF) or particles (D). Fibrils, particles or microcapsules incorporating a biologically active ingredient may be supplied for oral or nasal administration to an animal such as a human being.
摘要翻译： 一种用于从液体形成至少部分固体或凝胶状材料的分配装置和方法。 从出口排出的至少一种液体经受电场，导致液体形成至少一个带电的射流，其在形成后形成纤维（F）或分解成纤维碎片（FF）或颗粒（D） 。 由此形成的至少部分固体或凝胶状材料可以通过电场中的能量直接沉积到表面区域上，例如能够形成伤口敷料的皮肤区域 或具有高比表面积和极度吸收性的燃烧。 生物活性成分如药物成分或生物物质如DNA可以并入纤维（F），碎片（FF）或颗粒（D）中。 可以向动物如人提供包含生物活性成分的原纤维，颗粒或微胶囊用于口服或鼻腔给药。
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公开(公告)号：US06457470B1
公开(公告)日：2002-10-01
申请号：US09718023
申请日：2000-11-20
申请人： Ronald Alan Coffee
发明人： Ronald Alan Coffee
IPC分类号： A61M1100
CPC分类号： B05B5/002 , A61M15/0091 , A61M15/0093 , A61M15/02 , B05B5/0255 , B05B5/043
摘要： An inhaler for enabling inhaled administration, has a housing having an outlet duct defining a passageway through which air can be drawn by inhalation on the part of a user. The housing contains a capillary nozzle; a container for containing a quantity of liquid to be supplied to the capillary nozzle; and an electric field controller for applying a voltage to the liquid prior to issue from the container via the capillary nozzle to expose the liquid to an electric field to cause comminution of the liquid emerging from the capillary nozzle to product a spray of electrically charged droplets such that upon inhalation by the user, electrically charged droplets for the deposition in the user's airways.
摘要翻译： 用于实现吸入管理的吸入器具有壳体，该壳体具有限定通道的出口管道，通过该通道可以吸入使用者的空气。 外壳包含毛细管喷嘴; 容纳用于供给毛细喷嘴的液体的容器; 以及电场控制器，用于在从容器经由毛细管喷嘴发出之前向液体施加电压，以将液体暴露于电场，以使从毛细管喷嘴出来的液体粉碎以产生带电荷的液滴的喷雾， 在用户吸入时，带电的液滴用于在使用者的气道中沉积。
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公开(公告)号：US6105571A
公开(公告)日：2000-08-22
申请号：US492204
申请日：1995-06-02
申请人： Ronald Alan Coffee
发明人： Ronald Alan Coffee
CPC分类号： B05B5/002 , A61M15/0091 , A61M15/02 , B05B5/0255 , B05B5/043
摘要： An electrohydrodynamic dispensing device for comminuting a liquid which comprises a comminution site, a means for supplying liquid to the comminution site and a means for inducing an electrical charge at the comminution site sufficient to comminute the liquid supplied to it.
摘要翻译： 一种用于粉碎液体的电动液体动力学分配装置，其包括粉碎部位，用于向粉碎部位供给液体的装置和用于在粉碎部位引起足以粉碎供应到其的液体的电荷的装置。
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公开(公告)号：US6068199A
公开(公告)日：2000-05-30
申请号：US833875
申请日：1997-04-10
申请人： Ronald Alan Coffee
发明人： Ronald Alan Coffee
CPC分类号： B05B5/0255 , A61M15/00
摘要： A device for dispensing a comminuted liquid to the upper respiratory tract, which comprises an electrohydrodynamic comminution device and a supplier of a liquid to the comminution device. And a device for comminuting a liquid, the comminution site of which is provided by fibers projecting from an end surface or edge, the edge or surface being composed substantially of fibers.
摘要翻译： 一种用于将粉碎液体分配到上呼吸道的装置，其包括电动动力粉碎装置和向粉碎装置供给液体的装置。 还有一种用于粉碎液体的装置，其粉碎部位由从端表面或边缘突出的纤维提供，所述边缘或表面基本上由纤维组成。
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10.发明授权Liquid formations for electrohydrodymanic spraying containing polymer and suspended particles 失效含有聚合物和悬浮颗粒的电动水喷雾的液体组成公开(公告)号：US07891578B2
公开(公告)日：2011-02-22
申请号：US10472721
申请日：2002-03-22
IPC分类号： B05B5/025
CPC分类号： A61K9/0078 , A61K9/0073 , A61K9/12 , A61M11/00 , A61M15/02 , B05B5/1691
摘要： A method of providing a droplet spray, includes supplying a liquid polymer formulation within which substantially inert particulate material is suspended to an outlet and subjecting liquid issuing from the outlet to an electric field that causes the liquid to break up into droplets.
摘要翻译： 提供液滴喷雾的方法包括提供液体聚合物制剂，其中将基本上惰性的颗粒材料悬浮在出口处并使从出口释放的液体经受使液体分解成液滴的电场。
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