公开(公告)号：US20080021011A1

公开(公告)日：2008-01-24

申请号：US11770698

申请日：2007-06-28

申请人： Simon PLANKEN ,  Scott Sutton ,  Rongliang Chen

发明人： Simon PLANKEN ,  Scott Sutton ,  Rongliang Chen

IPC分类号： A61K31/397 ,  A61K31/415 ,  A61K31/44 ,  A61K31/454 ,  A61K31/496 ,  A61P31/18 ,  C07D211/80 ,  C07D249/04 ,  C07D401/14 ,  C07D403/02 ,  C07D405/06 ,  C07D413/14

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D409/14 ,  C07D413/14

摘要： The present invention provides compounds of formula (I), or pharmaceutically acceptable salts or solvates thereof, methods for their preparation, methods for their use, and pharmaceutical formulations comprising them.

摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐或溶剂化物，其制备方法，其使用方法和包含它们的药物制剂。

公开(公告)号：US20190105407A1

公开(公告)日：2019-04-11

申请号：US16089881

申请日：2017-03-30

申请人： Rongliang CHEN ,  Padma MANAM ,  Lu ZENG ,  TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Rongliang CHEN ,  Padma MANAM ,  Lu ZENG

IPC分类号： A61K47/69 ,  A61K31/4725 ,  A61K31/519

摘要： A complex of a compound of Formula 1, a stereoisomer thereof, or a tautomer of the compound of Formula 1 or stereoisomer thereof, and a cyclodextrin, in which the complex is an amorphous solid. This disclosure also relates to materials and methods for preparing the complex, to pharmaceutical compositions which contain the complex, and to the use of the complex to treat Type I hypersensitivity reactions, autoimmune diseases, inflammatory disorders, cancer, non-malignant proliferative disorders, and other conditions associated with BTK.

公开(公告)号：US20210138086A1

公开(公告)日：2021-05-13

申请号：US17145006

申请日：2021-01-08

申请人： Rongliang Chen ,  Padma Manam ,  Lu Zeng ,  Takeda Pharmaceutical Company Limited

发明人： Rongliang Chen ,  Padma Manam ,  Lu Zeng

IPC分类号： A61K47/69 ,  C08B37/16 ,  C07D401/14 ,  A61K31/4725 ,  A61K31/519

摘要： Disclosed is a complex of a compound of Formula 1, a stereoisomer thereof, or a tautomer of the compound of Formula 1 or stereoisomer thereof, and a cyclodextrin, in which the complex is an amorphous solid. This disclosure also relates to materials and methods for preparing the complex, to pharmaceutical compositions which contain the complex, and to the use of the complex to treat Type I hypersensitivity reactions, autoimmune diseases, inflammatory disorders, cancer, non-malignant proliferative disorders, and other conditions associated with BTK.

公开(公告)号：US20140206680A1

公开(公告)日：2014-07-24

申请号：US14128576

申请日：2012-06-20

申请人： Mark E. Adams ,  Rongliang Chen ,  Mitsunori Kono ,  Betty Lam ,  Matthew Lardy ,  Srinivasa Reddy Natala ,  Steven James Wilkens ,  Zhe Nie

发明人： Mark E. Adams ,  Rongliang Chen ,  Mitsunori Kono ,  Betty Lam ,  Matthew Lardy ,  Srinivasa Reddy Natala ,  Steven James Wilkens ,  Zhe Nie

IPC分类号： C07D498/04 ,  A61K31/437 ,  C07D495/04 ,  A61K31/519 ,  A61K31/5383 ,  C07D487/04 ,  A61K31/4985 ,  C07D471/04 ,  A61K31/4365

CPC分类号： C07D471/04 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5383 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

摘要： Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, p, R1, R2, R3a, R4, and R5 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, cancer, and other disorders, diseases, and conditions for which inhibition of SYK is indicated.

摘要翻译： 公开了式1的化合物及其药学上可接受的盐，其中G，p，R1，R2，R3a，R4和R5在说明书中定义。 本公开还涉及用于制备式1化合物的材料和方法，含有它们的药物组合物及其用于治疗涉及免疫系统和炎症的疾病，疾病和病症的用途，包括类风湿性关节炎，癌症和其它疾病 ，疾病和表示SYK抑制的病症。

公开(公告)号：US07919488B2

公开(公告)日：2011-04-05

申请号：US11770698

申请日：2007-06-28

申请人： Simon Paul Planken ,  Scott Channing Sutton ,  Rongliang Chen

发明人： Simon Paul Planken ,  Scott Channing Sutton ,  Rongliang Chen

IPC分类号： A61K31/397 ,  A61K31/415 ,  A61K31/454 ,  A61K31/496 ,  C07D211/80 ,  C07D401/14 ,  C07D403/02 ,  C07D405/06 ,  C07D413/14

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D409/14 ,  C07D413/14

摘要： The present invention provides compounds of formula (I), or pharmaceutically acceptable salts or solvates thereof, methods for their preparation, methods for their use, and pharmaceutical formulations comprising them.

公开(公告)号：US20060167056A1

公开(公告)日：2006-07-27

申请号：US11281295

申请日：2005-11-16

申请人： Raymond Rynberg ,  Rongliang Chen

发明人： Raymond Rynberg ,  Rongliang Chen

IPC分类号： A61K31/4439 ,  C07D403/14

CPC分类号： C07D401/14

摘要： The present invention relates to novel polymorphic forms of of 3{5-[3-(4,6-Difluoro-1H-benzoimidazol-2-yl)-1H-indazol-5-yl]-4-methyl-pyridin-3-ylmethyl}-ethyl-amine, and to processes for their preparation. Such polymorphic forms may be a component of a pharmaceutical composition and may be used to treat a hyperproliferative disorder or a mammalian disease condition mediated by protein kinase activity.

摘要翻译： 本发明涉及3 {5- [3-（4,6-二氟-1H-苯并咪唑-2-基）-1H-吲唑-5-基] -4-甲基 - 吡啶-3-基 吡啶-2-基甲基} - 乙基胺，并进行其制备。 这种多晶型物可以是药物组合物的组分，并且可以用于治疗由蛋白激酶活性介导的过度增殖性疾病或哺乳动物疾病状况。