公开(公告)号：US20140206680A1

公开(公告)日：2014-07-24

申请号：US14128576

申请日：2012-06-20

申请人： Mark E. Adams ,  Rongliang Chen ,  Mitsunori Kono ,  Betty Lam ,  Matthew Lardy ,  Srinivasa Reddy Natala ,  Steven James Wilkens ,  Zhe Nie

发明人： Mark E. Adams ,  Rongliang Chen ,  Mitsunori Kono ,  Betty Lam ,  Matthew Lardy ,  Srinivasa Reddy Natala ,  Steven James Wilkens ,  Zhe Nie

IPC分类号： C07D498/04 ,  A61K31/437 ,  C07D495/04 ,  A61K31/519 ,  A61K31/5383 ,  C07D487/04 ,  A61K31/4985 ,  C07D471/04 ,  A61K31/4365

CPC分类号： C07D471/04 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5383 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

摘要： Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, p, R1, R2, R3a, R4, and R5 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, cancer, and other disorders, diseases, and conditions for which inhibition of SYK is indicated.

摘要翻译： 公开了式1的化合物及其药学上可接受的盐，其中G，p，R1，R2，R3a，R4和R5在说明书中定义。 本公开还涉及用于制备式1化合物的材料和方法，含有它们的药物组合物及其用于治疗涉及免疫系统和炎症的疾病，疾病和病症的用途，包括类风湿性关节炎，癌症和其它疾病 ，疾病和表示SYK抑制的病症。

公开(公告)号：US09056873B2

公开(公告)日：2015-06-16

申请号：US14128576

申请日：2012-06-20

申请人： Mitsunori Kono ,  Zhe Nie

发明人： Mitsunori Kono ,  Zhe Nie

IPC分类号： A61K31/437 ,  C07D471/04 ,  C07D498/04 ,  C07D519/00 ,  A61K31/4365 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5383 ,  C07D487/04 ,  C07D495/04

CPC分类号： C07D471/04 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5383 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

摘要： Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, p, R1, R2, R3a, R4, and R5 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, cancer, and other disorders, diseases, and conditions for which inhibition of SYK is indicated.

摘要翻译： 公开了式1的化合物及其药学上可接受的盐，其中G，p，R1，R2，R3a，R4和R5在说明书中定义。 本公开还涉及用于制备式1化合物的材料和方法，含有它们的药物组合物及其用于治疗涉及免疫系统和炎症的疾病，疾病和病症的用途，包括类风湿性关节炎，癌症和其它疾病 ，疾病和表示SYK抑制的病症。

公开(公告)号：US5710415A

公开(公告)日：1998-01-20

申请号：US613002

申请日：1996-03-08

申请人： Mitsunori Kono ,  Yukio Tsuchiya ,  Kunio Matsushita

发明人： Mitsunori Kono ,  Yukio Tsuchiya ,  Kunio Matsushita

IPC分类号： G07G1/00 ,  G07G1/12

CPC分类号： G07G1/0018 ,  G07G1/12

摘要： A sales-registration-data processing apparatus includes a display unit being independent of a control unit housing and having a display portion on an outer surface thereof, and a tilt-angle adjustment and maintaining mechanism rotatably connecting the display unit to the housing, capable of tilting the display unit with respect to the housing and maintaining a desired tilt angle of the display unit. The tilt-angle adjustment and maintaining mechanism includes an erection guide groove formed in the outer surface of the housing and having a substantially circular-arc shaped vertical cross section, a guide projection mounted on a region of the outer surface of the display unit opposite to the display portion and being slidable along the erection guide groove of the housing, and a frictional-force adjustment mechanism mounted on the guide projection to be frictionally engaged with the erection guide groove and capable of adjusting frictional force generated between the frictional-force adjustment mechanism and the erection guide groove.

摘要翻译： 销售登记数据处理装置包括独立于控制单元壳体并且在其外表面上具有显示部分的显示单元以及将显示单元可旋转地连接到壳体的倾斜角调节和保持机构，能够 相对于壳体倾斜显示单元并保持显示单元的期望的倾斜角度。 倾斜角度调节和保持机构包括形成在壳体的外表面中并且具有基本上圆弧形的垂直横截面的竖立引导槽，安装在显示单元的外表面的区域上的引导突起， 所述显示部分能够沿着所述壳体的竖立引导槽滑动;以及摩擦力调节机构，其安装在所述引导突起上以与所述安装引导槽摩擦接合，并且能够调节所述摩擦力调节机构 和架设引导槽。