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1.MORPHOLINO SUBSTITUTED UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS 有权
标题翻译: 作为MTOR抑制剂的吗啉取代的尿素或碳酸酯衍生物公开(公告)号:US20140378438A1
公开(公告)日:2014-12-25
申请号:US14346332
申请日:2012-09-21
申请人: Rosemary Lynch , Andrew David Cansfield , Daniel Paul Hardy , Mihiro Sunose , Adeline Morel , Laura Convery , Rita Adrego
发明人: Rosemary Lynch , Andrew David Cansfield , Daniel Paul Hardy , Mihiro Sunose , Adeline Morel , Laura Convery , Rita Adrego
IPC分类号: C07D498/08 , C07D413/14 , C07D413/04
CPC分类号: C07D498/08 , C07D251/22 , C07D401/12 , C07D407/12 , C07D413/04 , C07D413/14
摘要: The invention relates to compounds of formula (I) wherein m, n, R1, T0 and T1 have the meaning as cited in the description and the claims. The compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds as well as methods of treating mTOR related diseases.
摘要翻译: 本发明涉及式(I)化合物,其中m,n,R 1,T 0和T 1具有在说明书和权利要求书中引用的含义。 该化合物可用作mTOR的抑制剂,用于治疗或预防mTOR相关疾病和病症。 本发明还涉及包含所述化合物的药物组合物以及治疗mTOR相关疾病的方法。
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公开(公告)号:US20120269864A1
公开(公告)日:2012-10-25
申请号:US13493110
申请日:2012-06-11
申请人: Haiyan Jia , Ian ZACHARY , Michelle TICKNER , Lili CHENG , Chris CHAPMAN , Katie ELLARD , Basil HARTZOULAKIS , Ashley JARVIS , Rosemary LYNCH , Jamie NALLY , David SELWOOD , Mark STEWART
发明人: Haiyan Jia , Ian ZACHARY , Michelle TICKNER , Lili CHENG , Chris CHAPMAN , Katie ELLARD , Basil HARTZOULAKIS , Ashley JARVIS , Rosemary LYNCH , Jamie NALLY , David SELWOOD , Mark STEWART
IPC分类号: A61K31/433 , A61K31/381 , C07D417/12 , C07D409/14 , A61K31/4436 , C07D413/12 , A61K31/538 , A61K31/506 , C07D498/04 , A61K31/5383 , A61K31/4245 , C07F5/02 , A61K31/69 , A61P25/28 , A61P25/00 , A61P35/00 , A61P37/02 , C07D409/12 , C07C279/14 , A61K31/197 , C07D277/56 , A61K31/4168 , C07D333/38
CPC分类号: C07D333/38 , C07C279/12 , C07D277/56 , C07D307/68 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要: The present invention is a compound of formula (I) or formula (II) which are suitable as NP-1 antagonists.
摘要翻译: 本发明是适合作为NP-1拮抗剂的式(I)或式(II)的化合物。
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公开(公告)号:US08227606B2
公开(公告)日:2012-07-24
申请号:US13361134
申请日:2012-01-30
申请人: Haiyan Jia , Ian Zachary , Michelle Tickner , Lili Cheng , Chris Chapman , Katie Ellard , Basil Hartzoulakis , Ashley Jarvis , Rosemary Lynch , Jamie Nally , David Selwood , Mark Stewart
发明人: Haiyan Jia , Ian Zachary , Michelle Tickner , Lili Cheng , Chris Chapman , Katie Ellard , Basil Hartzoulakis , Ashley Jarvis , Rosemary Lynch , Jamie Nally , David Selwood , Mark Stewart
IPC分类号: C07D417/14
CPC分类号: C07D333/38 , C07C279/12 , C07D277/56 , C07D307/68 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要: The present invention is a compound of formula (I) or formula (II) which are suitable as NP-1 antagonists.
摘要翻译: 本发明是适合作为NP-1拮抗剂的式(I)或式(II)的化合物。
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公开(公告)号:US08158789B2
公开(公告)日:2012-04-17
申请号:US12439523
申请日:2007-10-04
申请人: Haiyan Jia , Ian Zachary , Michelle Tickner , Lili Cheng , Chris Chapman , Katie Ellard , Basil Hartzoulakis , Ashley Jarvis , Rosemary Lynch , Jamie Nally , David Selwood , Mark Stewart
发明人: Haiyan Jia , Ian Zachary , Michelle Tickner , Lili Cheng , Chris Chapman , Katie Ellard , Basil Hartzoulakis , Ashley Jarvis , Rosemary Lynch , Jamie Nally , David Selwood , Mark Stewart
IPC分类号: C07D409/14
CPC分类号: C07D333/38 , C07C279/12 , C07D277/56 , C07D307/68 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要: The present invention is a compound of formula (I) or formula (II) which are suitable as NP-1 antagonists.
摘要翻译: 本发明是适合作为NP-1拮抗剂的式(I)或式(II)的化合物。
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公开(公告)号:US20120122862A1
公开(公告)日:2012-05-17
申请号:US13361134
申请日:2012-01-30
申请人: Haiyan Jia , Ian Zachary , Michelle Tickner , Lili Cheng , Chris Chapman , Katie Ellard , Basil Hartzoulakis , Ashley Jarvis , Rosemary Lynch , Jamie Nally , David Selwood , Mark Stewart
发明人: Haiyan Jia , Ian Zachary , Michelle Tickner , Lili Cheng , Chris Chapman , Katie Ellard , Basil Hartzoulakis , Ashley Jarvis , Rosemary Lynch , Jamie Nally , David Selwood , Mark Stewart
IPC分类号: A61K31/538 , A61K31/197 , C07D333/38 , A61K31/381 , C07C311/46 , C07D277/56 , A61K31/426 , C07D307/68 , A61K31/341 , C07D417/12 , A61K31/433 , C07D409/12 , A61K31/4436 , C07D409/14 , C07D413/12 , C07D498/04 , A61K31/5383 , A61P25/00 , A61P25/28 , A61P35/00 , A61P37/02 , C07C279/14
CPC分类号: C07D333/38 , C07C279/12 , C07D277/56 , C07D307/68 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要: The present invention is a compound of formula (I) or formula (II) which are suitable as NP-1 antagonists.
摘要翻译: 本发明是适合作为NP-1拮抗剂的式(I)或式(II)的化合物。
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公开(公告)号:US20120065202A1
公开(公告)日:2012-03-15
申请号:US13256345
申请日:2010-03-12
申请人: Rosemary Lynch , Andrew David Cansfield , Helen Sarah Niblock , Daniel Hardy , Jane Elizabeth Scanlon , Rita Adrego , Nigel Ramsden
发明人: Rosemary Lynch , Andrew David Cansfield , Helen Sarah Niblock , Daniel Hardy , Jane Elizabeth Scanlon , Rita Adrego , Nigel Ramsden
IPC分类号: A61K31/5377 , A61P37/00 , A61P29/00 , A61P25/28 , A61P37/06 , A61P35/00 , A61P9/00 , A61P3/00 , C07D487/04 , A61P37/08
CPC分类号: C07D413/04 , A61K31/5377 , C07D471/04 , C07D487/04
摘要: The invention relates to compounds of formula (I) wherein X, R1, R2, T, m, n, o have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
摘要翻译: 本发明涉及式(I)化合物,其中X,R 1,R 2,T,m,n,o具有在说明书和权利要求书中引用的含义。 所述化合物可用作mTOR的抑制剂,用于治疗或预防mTOR相关疾病和病症。 本发明还涉及包含所述化合物的药物组合物,这些化合物的制备以及作为药物的用途。
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7.Azacyclic compounds as inhibitors of sensory neurone specific channels 审中-公开
标题翻译: 偶氮化合物作为感觉神经元特异性通道的抑制剂公开(公告)号:US20070043024A1
公开(公告)日:2007-02-22
申请号:US10563561
申请日:2004-07-07
申请人: Richard Hamlyn , Michael Huckstep , Rosemary Lynch , Stephen Stokes , David Tickle , Lee Patient
发明人: Richard Hamlyn , Michael Huckstep , Rosemary Lynch , Stephen Stokes , David Tickle , Lee Patient
IPC分类号: A61L9/04 , A61K31/55 , A61K31/47 , A61K31/4745
CPC分类号: A61K31/47 , A61K31/4745 , A61K31/55
摘要: Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents wherein: X is —N— or —CH—; n is from 0 to 3.
摘要翻译: 发现式(I)化合物及其药学上可接受的盐是SNS钠通道的拮抗剂。 因此它们可用作止痛剂和神经保护剂,其中:X是-N-或-CH-; n为0〜3。
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公开(公告)号:US08785457B2
公开(公告)日:2014-07-22
申请号:US13256345
申请日:2010-03-12
申请人: Rosemary Lynch , Andrew David Cansfield , Helen Sarah Niblock , Daniel Hardy , Jane Elizabeth Scanlon , Rita Adrego , Nigel Ramsden
发明人: Rosemary Lynch , Andrew David Cansfield , Helen Sarah Niblock , Daniel Hardy , Jane Elizabeth Scanlon , Rita Adrego , Nigel Ramsden
IPC分类号: A61K31/5377 , C07D413/04
CPC分类号: C07D413/04 , A61K31/5377 , C07D471/04 , C07D487/04
摘要: The invention relates to compounds of formula (I) wherein X, R1, R2, T, m, n, o have the meaning as cited in the description and the claims. The compounds of formula (I) are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
摘要翻译: 本发明涉及式(I)化合物,其中X,R 1,R 2,T,m,n,o具有在说明书和权利要求书中引用的含义。 式(I)化合物可用作mTOR的抑制剂,用于治疗或预防mTOR相关疾病和病症。 本发明还涉及包含所述化合物的药物组合物,这些化合物的制备以及作为药物的用途。
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公开(公告)号:US20140163023A1
公开(公告)日:2014-06-12
申请号:US14009846
申请日:2012-04-02
申请人: Rosemary Lynch , Andrew David Cansfield , Daniel Paul Hardy , Jane Elizabeth Scanlon , Rita Joana Rodrigues Adrego
发明人: Rosemary Lynch , Andrew David Cansfield , Daniel Paul Hardy , Jane Elizabeth Scanlon , Rita Joana Rodrigues Adrego
IPC分类号: C07D487/04
CPC分类号: C07D487/04
摘要: The invention relates to compounds of formula (I) wherein X, R1, R2, T0, o have the meaning as cited in the description and the claims. The compounds of formula I are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including the compounds of formula I, the preparation of such compounds as well as the use as medicaments.
摘要翻译: 本发明涉及式(I)的化合物,其中X,R1,R2,T0,o具有在说明书和权利要求书中引用的含义。 式I的化合物可用作mTOR的抑制剂,用于治疗或预防mTOR相关疾病和病症。 本发明还涉及包含式I化合物,这些化合物的制备以及用作药物的药物组合物。
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公开(公告)号:US20130196982A1
公开(公告)日:2013-08-01
申请号:US13582429
申请日:2011-03-04
申请人: Rosemary Lynch , Andrew David Cansfield , Helen Sarah Niblock , Daniel Paul Hardy , Jessica Taylor
发明人: Rosemary Lynch , Andrew David Cansfield , Helen Sarah Niblock , Daniel Paul Hardy , Jessica Taylor
IPC分类号: C07D413/14 , C07D413/04 , C07D498/08 , C07D401/04
CPC分类号: C07D413/14 , A61K31/5377 , C07D239/42 , C07D401/04 , C07D413/04 , C07D498/08
摘要: The invention relates to compounds of formula (I) wherein X1, X2, R1 to R4, m, n have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
摘要翻译: 本发明涉及式(I)化合物,其中X 1,X 2,R 1至R 4,m,n具有在说明书和权利要求书中引用的含义。 所述化合物可用作mTOR的抑制剂,用于治疗或预防mTOR相关疾病和病症。 本发明还涉及包含所述化合物的药物组合物,这些化合物的制备以及作为药物的用途。
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