公开(公告)号：US20060124152A1

公开(公告)日：2006-06-15

申请号：US10524903

申请日：2002-12-10

申请人： Gang Li ,  Wanli Xing ,  Ruige Wu ,  Min Guo ,  Jing Cheng

发明人： Gang Li ,  Wanli Xing ,  Ruige Wu ,  Min Guo ,  Jing Cheng

IPC分类号： B08B3/10

CPC分类号： B08B3/12 ,  C12Q1/6813 ,  C12Q2523/301

摘要： A method and apparatus for washing solid substrate with ultrasonic wave after hybridization reaction are provided. The method includes (1) putting the solid substrate into a container having a washing solution, on which the hybridization reaction has been completed, (2) using an ultrasonic generator to produce a certain strength of ultrasonic wave and transmit it into the washing solution, (3) washing the substrate by means of the cavitation effect being produced in the washing solution by the ultrasonic wave. Since the cavitation bubbles in the washing solution can produce intensive efflux and local microslipstream against the solid surface, evidently reducing the liquid surface tension and friction and enhance the liquid flow, non-specific adsorbate and deposit bound weakly on the solid substrate can be washed down rapidly.

摘要翻译： 提供了一种用于在杂交反应之后用超声波洗涤固体底物的方法和装置。 该方法包括：（1）将固体基质置于具有杂交反应完成的洗涤液的容器中，（2）使用超声波发生器产生一定强度的超声波并将其输送到洗涤液中， （3）通过超声波在洗涤液中产生的空化作用洗涤基板。 由于洗涤液中的气穴气泡能够对固体表面产生强烈的流出和局部微滑流，明显降低了液面张力和摩擦力，增强了液体流动，固体基质上弱结合的非特异性吸附物和沉积物可以被冲洗掉 迅速