公开(公告)号：US07280680B2

公开(公告)日：2007-10-09

申请号：US10377671

申请日：2003-03-04

申请人： Hideo Yokota ,  Sakiko Nakamura ,  Atsushi Yoshiki ,  Akitake Makinouchi ,  Ryutaro Himeno ,  Toshiro Higuchi

发明人： Hideo Yokota ,  Sakiko Nakamura ,  Atsushi Yoshiki ,  Akitake Makinouchi ,  Ryutaro Himeno ,  Toshiro Higuchi

IPC分类号： G06K9/00

CPC分类号： G06T7/0012 ,  G06T7/70 ,  G06T2207/30004

摘要： In order to make observation of localizations of in vivo expressed genes possible in an entire individual living organism such as animals, and plants, a living genetic recombinant specimen containing a marker that can be detected at the time when specific genes are expressed is sequentially severed, sectional images each of which corresponds to an image of sections severed are photographed in every scissions of the living specimen, and three-dimensional observation of the living specimen is implemented on the basis of the images photographed in every scissions described above, whereby three-dimensional localizations of expressed genes are observed in the living specimen.

摘要翻译： 为了观察在动物和植物等整个个体活体中可能存在的体内表达基因的定位，依次切断含有表达特定基因时可检测的标志物的活的遗传重组标本， 在活体样本的每个划痕中拍摄各自对应于切片的图像的截面图像，并且基于在上述每个扫描中拍摄的图像来实施活体样本的三维观察，由此三维 在活体标本中观察到表达基因的定位。

公开(公告)号：US20060089803A1

公开(公告)日：2006-04-27

申请号：US10540861

申请日：2003-12-12

申请人： Kangbin Lei ,  Masako Iwata ,  Ryutaro Himeno ,  Kiwamu Kase

发明人： Kangbin Lei ,  Masako Iwata ,  Ryutaro Himeno ,  Kiwamu Kase

IPC分类号： G06F19/00

CPC分类号： G06F17/5018 ,  G06F2217/16

摘要： A method including: a dividing step (A) of dividing external data into a plurality of cells (13) having boundaries orthogonal to each other, the external data including boundary data of an object which contacts incompressible viscous fluid; a cell classifying step (B) of classifying the divided cells into an internal cell (13a) positioned inside or outside the object and a boundary cell (13b) including the boundary data; a cut point determining step (C) of determining cut points in ridges of the boundary cell on the basis of the boundary data; a boundary face determining step (D) of determining a polygon connecting the cut points to be cell internal data for the boundary face; and a analyzing step (E) of applying a cut cell finite volume method combined with a VOF method to a boundary of a flow field to analyze the flow field.

摘要翻译： 一种方法，包括：将外部数据划分成具有彼此正交的边界的多个单元（13）的分割步骤（A），所述外部数据包括接触不可压缩粘性流体的物体的边界数据; 将分割的单元分类为位于物体内部或外部的内部单元（13a）的单元分类步骤（B）和包括边界数据的边界单元（13b）; 根据边界数据确定边界单元的脊的切点的切点确定步骤（C）; 边界面确定步骤（D），确定将所述切割点连接成为所述边界面的单元格内部数据的多边形; 以及将与VOF方法组合的切割单元有限体积方法应用于流场的边界以分析流场的分析步骤（E）。

公开(公告)号：US07088363B2

公开(公告)日：2006-08-08

申请号：US10058905

申请日：2002-01-30

申请人： Kiwamu Kase ,  Hideo Tashiro ,  Ryutaro Himeno ,  Akitake Makinouchi

发明人： Kiwamu Kase ,  Hideo Tashiro ,  Ryutaro Himeno ,  Akitake Makinouchi

IPC分类号： G06T17/00

CPC分类号： G06T17/005 ,  G06F17/5018

摘要： A method of storing substantial data integrating shape and physical properties comprising (A) inputting external data 12 consisting of boundary data of an object 1, (B) dividing, by modified Octree division, the external data into cubical cells 13 which boundary surfaces are orthogonal to each other, and (C) storing the values of various physical properties for each of the cells. Furthermore, in step (B), each of the divided cells 13 is classified to non-boundary cells 13a located in the interior of the object or in a region outside of the object, and boundary cells 13b including boundary surfaces. Thereby, substantial data integrating shape and physical properties can be stored in small storage capacity, thus enabling the integration of CAD and simulation.

摘要翻译： 一种存储整合形状和物理性质的实质数据的方法，包括（A）输入由对象1的边界数据组成的外部数据12，（B）通过修改的八叉树划分将外部数据划分成立方单元13，该边界表面正交 并且（C）存储每个单元的各种物理性质的值。 此外，在步骤（B）中，将分割单元13分类为位于物体内部或物体外部的区域的非边界单元13a以及包含边界面的边界单元13b。 因此，整合形状和物理性质的实质数据可以以小的存储容量存储，从而实现CAD和仿真的集成。

公开(公告)号：US07430500B2

公开(公告)日：2008-09-30

申请号：US10540861

申请日：2003-12-12

申请人： Kangbin Lei ,  Masako Iwata ,  Ryutaro Himeno ,  Kiwamu Kase

发明人： Kangbin Lei ,  Masako Iwata ,  Ryutaro Himeno ,  Kiwamu Kase

IPC分类号： C06G7/48

CPC分类号： G06F17/5018 ,  G06F2217/16

摘要： A method including: a dividing step (A) of dividing external data into a plurality of cells (13) having boundaries orthogonal to each other, the external data including boundary data of an object which contacts incompressible viscous fluid; a cell classifying step (B) of classifying the divided cells into an internal cell (13a) positioned inside or outside the object and a boundary cell (13b) including the boundary data; a cut point determining step (C) of determining cut points in ridges of the boundary cell on the basis of the boundary data; a boundary face determining step (D) of determining a polygon connecting the cut points to be cell internal data for the boundary face; and a analyzing step (E) of applying a cut cell finite volume method combined with a VOF method to a boundary of a flow field to analyze the flow field.

摘要翻译： 一种方法，包括：将外部数据划分成具有彼此正交的边界的多个单元（13）的分割步骤（A），所述外部数据包括接触不可压缩粘性流体的物体的边界数据; 将分割的单元分类为位于物体内部或外部的内部单元（13a）的单元分类步骤（B）和包括边界数据的边界单元（13b）; 根据边界数据确定边界单元的脊的切点的切点确定步骤（C）; 边界面确定步骤（D），确定将所述切割点连接成为所述边界面的单元格内部数据的多边形; 以及将与VOF方法组合的切割单元有限体积方法应用于流场的边界以分析流场的分析步骤（E）。

公开(公告)号：US07366334B2

公开(公告)日：2008-04-29

申请号：US10627979

申请日：2003-07-28

申请人： Hideo Yokota ,  Satoko Takemoto ,  Taketoshi Mishima ,  Akitake Makinouchi ,  Ryutaro Himeno

发明人： Hideo Yokota ,  Satoko Takemoto ,  Taketoshi Mishima ,  Akitake Makinouchi ,  Ryutaro Himeno

IPC分类号： G06K9/00

CPC分类号： G06K9/4638 ,  G06K9/3233 ,  G06K2009/366 ,  G06K2209/05 ,  G06T7/11 ,  G06T7/12 ,  G06T7/187 ,  G06T2200/04 ,  G06T2207/20104 ,  G06T2207/20116 ,  G06T2207/30004

摘要： Assuming that there are three continuous frames, i.e, cross sectional images of an organism, a dummy region of interest (ROI) is specified manually in the first frame, a temporary ROI is set in the second frame at the same position as that of the dummy ROI in the first frame. Whether a specific region in the second frame is inside or outside of a true ROI is judged based on the initial judgment criterion and values of pixels in the specific region. Whether a specific region in the third frame is inside or outside of the true ROI is judged based on values of pixels of regions that have been judged to be inside the region of interest in the second frame.

摘要翻译： 假设存在三个连续帧，即生物体的横截面图像，在第一帧中手动指定感兴趣的虚拟区域（ROI），在第二帧中设置与第二帧相同位置的临时ROI 虚拟ROI在第一帧。 基于特定区域中的初始判定基准和像素值，判断第二帧中的特定区域是否在真实ROI内部或外部。 基于在第二帧中被判断为在感兴趣区域内的区域的像素的值来判断第三帧中的特定区域是否在真实ROI内部或外部。

公开(公告)号：US20060200318A1

公开(公告)日：2006-09-07

申请号：US11218466

申请日：2005-09-06

申请人： So-ichiro Morishita ,  Hideo Yokota ,  Ryutaro Himeno ,  Taketoshi Mishima

发明人： So-ichiro Morishita ,  Hideo Yokota ,  Ryutaro Himeno ,  Taketoshi Mishima

IPC分类号： G06F19/00 ,  G01N31/00

CPC分类号： G01N21/6428 ,  G01N2201/1293

摘要： It is an object of the invention to provide an estimation method of fluorescent dye's concentration from multiple fluorescence, where the accurate estimation of the fluorescent dye's concentration of each fluorescent dye from multiple fluorescence is made possible and the separation of multiple fluorescence which is difficult in the prior art is made possible. In the estimation method of fluorescent dye's concentration from multiple fluorescence where the fluorescent dye's concentration from measured multiple fluorescence, independent component analysis is performed to the spectrum of fluorescent dye where fluorescent dye's concentration is known to derive the intensity of an independent component, regression analysis is performed by using the derived intensity of the independent component as a variable to estimate the fluorescent dye's concentration function of the fluorescent dye where the fluorescent dye's concentration is known, and the concentration of fluorescent dye is estimated from the measured multiple fluorescence based on the estimated fluorescent dye's concentration function.

摘要翻译： 本发明的一个目的是提供一种荧光染料从多个荧光的浓度的估计方法，其中可以准确地估计荧光染料从多个荧光的荧光染料的浓度，并且在多个荧光中难以分离多个荧光 现有技术成为可能。 在荧光染料浓度从荧光染料浓度测量多个荧光的荧光染料浓度的估计方法中，对已知荧光染料浓度的荧光染料的光谱进行独立成分分析，得出独立成分的强度，回归分析为 通过使用独立成分的衍生强度作为变量来进行荧光染料的荧光染料的浓度函数的荧光染料的浓度的测定，荧光染料的浓度是已知的，荧光染料的浓度是根据测定的多个荧光估计的 染料的浓度功能。