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公开(公告)号:US20100291110A1
公开(公告)日:2010-11-18
申请号:US12813040
申请日:2010-06-10
申请人: Søren Berg Padkjaer , Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Peter Andreas Nicolai Reumert Wagtmann
发明人: Søren Berg Padkjaer , Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Peter Andreas Nicolai Reumert Wagtmann
IPC分类号: A61K39/395 , C07K16/00 , A61P37/00
CPC分类号: C07K16/2803 , C07K2317/21 , G01N33/5047
摘要: The present invention relates to novel compositions and methods for regulating an immune response in a subject. More particularly, the invention relates to specific antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects. The invention also relates to fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly in therapy, to increase NK cell activity or cytotoxicity in subjects.
摘要翻译: 本发明涉及用于调节受试者的免疫应答的新型组合物和方法。 更具体地,本发明涉及调节NK细胞活性并允许在哺乳动物受试者中增强NK细胞细胞毒性的特异性抗体。 本发明还涉及这种抗体的片段和衍生物,以及包含其的药物组合物及其用途,特别是在治疗中,以增加受试者的NK细胞活性或细胞毒性。
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公开(公告)号:US20110052606A1
公开(公告)日:2011-03-03
申请号:US12811990
申请日:2009-01-23
申请人: Petrus Johannes Louis Spee , Jianhe Chen , Søren Berg Padkjaer , Jing Su , Jinchao Zhang , Jiujiu Yu
发明人: Petrus Johannes Louis Spee , Jianhe Chen , Søren Berg Padkjaer , Jing Su , Jinchao Zhang , Jiujiu Yu
CPC分类号: C07K16/2851 , C07K16/2803 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to agents that are non-competitive antagonists of the CD94/NKG2A receptor such as certain anti-NKG2A antibodies, in particular humanized versions of murine anti-NKG2A antibody Z199, as well as methods of producing and using such agents and antibodies.
摘要翻译: 本发明涉及作为CD94 / NKG2A受体的非竞争性拮抗剂如某些抗NKG2A抗体,特别是鼠抗NKG2A抗体Z199的人源化形式的试剂,以及制备和使用这些试剂和抗体的方法 。
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