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公开(公告)号:US20100291110A1
公开(公告)日:2010-11-18
申请号:US12813040
申请日:2010-06-10
申请人: Søren Berg Padkjaer , Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Peter Andreas Nicolai Reumert Wagtmann
发明人: Søren Berg Padkjaer , Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Peter Andreas Nicolai Reumert Wagtmann
IPC分类号: A61K39/395 , C07K16/00 , A61P37/00
CPC分类号: C07K16/2803 , C07K2317/21 , G01N33/5047
摘要: The present invention relates to novel compositions and methods for regulating an immune response in a subject. More particularly, the invention relates to specific antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects. The invention also relates to fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly in therapy, to increase NK cell activity or cytotoxicity in subjects.
摘要翻译: 本发明涉及用于调节受试者的免疫应答的新型组合物和方法。 更具体地,本发明涉及调节NK细胞活性并允许在哺乳动物受试者中增强NK细胞细胞毒性的特异性抗体。 本发明还涉及这种抗体的片段和衍生物,以及包含其的药物组合物及其用途,特别是在治疗中,以增加受试者的NK细胞活性或细胞毒性。
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公开(公告)号:US08637258B2
公开(公告)日:2014-01-28
申请号:US12813040
申请日:2010-06-10
申请人: Soren Berg Padkjaer , Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Peter Andreas Nicolai Reumert Wagtmann
发明人: Soren Berg Padkjaer , Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Peter Andreas Nicolai Reumert Wagtmann
IPC分类号: G01N33/53 , G01N33/567 , C12P21/08 , C07K16/00
CPC分类号: C07K16/2803 , C07K2317/21 , G01N33/5047
摘要: The present invention relates to a method of producing an antibody that cross-reacts with multiple KIR2DL polypeptides and neutralizes the inhibitory activity of such polypeptides.
摘要翻译: 本发明涉及产生与多个KIR2DL多肽交叉反应并中和这些多肽的抑制活性的抗体的方法。
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公开(公告)号:US20120208237A1
公开(公告)日:2012-08-16
申请号:US13347832
申请日:2012-01-11
申请人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagné , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thórólfsson , Søren Berg Padkær , Kristian Kjaergaard , Pieter Spee , Michael Wilken
发明人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagné , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thórólfsson , Søren Berg Padkær , Kristian Kjaergaard , Pieter Spee , Michael Wilken
CPC分类号: C07K16/42 , C07K16/28 , C07K16/2803 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
摘要翻译: 描述了用于调节受试者的免疫应答的组合物和方法。 更具体地,描述了调节NK细胞活性并允许在哺乳动物受试者中增强NK细胞细胞毒性的人抗体,以及具有与人单克隆抗体1-7F9或1-4F1类似的抗原结合特性的抗体。 还描述了这种抗体的片段和衍生物,以及包含其的药物组合物及其用途,特别是用于治疗,以增加受试者的NK细胞活性或细胞毒性。
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公开(公告)号:US08119775B2
公开(公告)日:2012-02-21
申请号:US12244170
申请日:2008-10-02
申请人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagné , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thórólfsson , Søren Berg Padkær , Kristian Kjaergaard , Pieter Spee , Michael Wilken
发明人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagné , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thórólfsson , Søren Berg Padkær , Kristian Kjaergaard , Pieter Spee , Michael Wilken
CPC分类号: C07K16/42 , C07K16/28 , C07K16/2803 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
摘要翻译: 描述了用于调节受试者的免疫应答的组合物和方法。 更具体地,描述了调节NK细胞活性并允许在哺乳动物受试者中增强NK细胞细胞毒性的人抗体,以及具有与人单克隆抗体1-7F9或1-4F1类似的抗原结合特性的抗体。 还描述了这种抗体的片段和衍生物,以及包含其的药物组合物及其用途,特别是用于治疗,以增加受试者的NK细胞活性或细胞毒性。
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公开(公告)号:US20090081240A1
公开(公告)日:2009-03-26
申请号:US12244170
申请日:2008-10-02
申请人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagne , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thorolfsson , Soren Berg Padkaer , Kristian Kjaergaard , Pieter Spee , Michael Wilken
发明人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagne , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thorolfsson , Soren Berg Padkaer , Kristian Kjaergaard , Pieter Spee , Michael Wilken
CPC分类号: C07K16/42 , C07K16/28 , C07K16/2803 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
摘要翻译: 描述了用于调节受试者的免疫应答的组合物和方法。 更具体地,描述了调节NK细胞活性并允许哺乳动物受试者中NK细胞细胞毒性增强的抗体,以及具有与人单克隆抗体1-7F9或1-4F1类似的抗原结合特性的抗体。 还描述了这种抗体的片段和衍生物,以及包含其的药物组合物及其用途,特别是用于治疗,以增加受试者的NK细胞活性或细胞毒性。
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公开(公告)号:US08614307B2
公开(公告)日:2013-12-24
申请号:US13347832
申请日:2012-01-11
申请人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurant Gauthier , Francois Romagne , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thorolfsson , Soren Berg Padkjaer , Kristian Kjaergaard , Petrus Johannes Loius Spee , Milchael Wilken
发明人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurant Gauthier , Francois Romagne , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thorolfsson , Soren Berg Padkjaer , Kristian Kjaergaard , Petrus Johannes Loius Spee , Milchael Wilken
IPC分类号: C07H21/04
CPC分类号: C07K16/42 , C07K16/28 , C07K16/2803 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
摘要翻译: 描述了用于调节受试者的免疫应答的组合物和方法。 更具体地,描述了调节NK细胞活性并允许在哺乳动物受试者中增强NK细胞细胞毒性的人抗体,以及具有与人单克隆抗体1-7F9或1-4F1类似的抗原结合特性的抗体。 还描述了这种抗体的片段和衍生物,以及包含其的药物组合物及其用途,特别是用于治疗,以增加受试者的NK细胞活性或细胞毒性。
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公开(公告)号:US20060280740A1
公开(公告)日:2006-12-14
申请号:US11324356
申请日:2006-01-03
申请人: Soren Padkjaer , Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Peter Reumert Wagtmann
发明人: Soren Padkjaer , Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Peter Reumert Wagtmann
IPC分类号: A61K39/395 , C12P21/04 , C12N5/06 , C07K16/28
CPC分类号: C07K16/2803 , C07K2317/21 , G01N33/5047
摘要: The present invention relates to novel compositions and methods for regulating an immune response in a subject. More particularly, the invention relates to specific antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects. The invention also relates to fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly in therapy, to increase NK cell activity or cytotoxicity in subjects.
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公开(公告)号:US20090191213A9
公开(公告)日:2009-07-30
申请号:US11324356
申请日:2006-01-03
申请人: Soren Padkjaer , Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Peter Reumert Wagtmann
发明人: Soren Padkjaer , Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Peter Reumert Wagtmann
IPC分类号: A61K39/395 , C12P21/04 , C12N5/06 , C07K16/28
CPC分类号: C07K16/2803 , C07K2317/21 , G01N33/5047
摘要: The present invention relates to novel compositions and methods for regulating an immune response in a subject. More particularly, the invention relates to specific antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects. The invention also relates to fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly in therapy, to increase NK cell activity or cytotoxicity in subjects.
摘要翻译: 本发明涉及用于调节受试者的免疫应答的新型组合物和方法。 更具体地,本发明涉及调节NK细胞活性并允许在哺乳动物受试者中增强NK细胞细胞毒性的特异性抗体。 本发明还涉及这种抗体的片段和衍生物,以及包含其的药物组合物及其用途,特别是在治疗中,以增加受试者的NK细胞活性或细胞毒性。
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公开(公告)号:US08993319B2
公开(公告)日:2015-03-31
申请号:US11720553
申请日:2005-12-27
CPC分类号: C07K16/2896 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/572 , C07K16/2851 , C07K2317/21 , C07K2317/76 , G01N33/56966 , G01N2333/70596 , G01N2500/04
摘要: The present invention relates to methods of treating immune disorders, particularly autoimmune or inflammatory disorders, and methods of producing antibodies and other compounds for use in therapeutic strategies for treating such disorders. Generally, the present methods involve the use of antibodies or other compounds that prevent the stimulation of NKG2A receptors on NK cells, leading to the lysis of dendritic cells that contribute to the pathology of the disorders.
摘要翻译: 本发明涉及治疗免疫疾病,特别是自身免疫性或炎症性疾病的方法,以及产生用于治疗这种病症的治疗策略的抗体和其它化合物的方法。 通常,本发明的方法包括使用抗体或其它化合物,其阻止NK细胞上的NKG2A受体的刺激,导致有助于疾病病理学的树突细胞的裂解。
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公开(公告)号:US20090208416A1
公开(公告)日:2009-08-20
申请号:US11720553
申请日:2005-12-27
IPC分类号: A61K49/00 , C07K16/28 , A61K39/395 , C12N5/00 , C12N5/08 , G01N33/53 , A61P29/00 , A61P37/04 , A61P35/00
CPC分类号: C07K16/2896 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/572 , C07K16/2851 , C07K2317/21 , C07K2317/76 , G01N33/56966 , G01N2333/70596 , G01N2500/04
摘要: The present invention relates to methods of treating immune disorders, particularly autoimmune or inflammatory disorders, and methods of producing antibodies and other compounds for use in therapeutic strategies for treating such disorders. Generally, the present methods involve the use of antibodies or other compounds that prevent the stimulation of NKG2A receptors on NK cells, leading to the lysis of dendritic cells that contribute to the pathology of the disorders.
摘要翻译: 本发明涉及治疗免疫疾病,特别是自身免疫性或炎症性疾病的方法,以及产生用于治疗这种病症的治疗策略的抗体和其它化合物的方法。 通常,本发明的方法包括使用抗体或其它化合物,其阻止NK细胞上的NKG2A受体的刺激,导致有助于疾病病理学的树突细胞的裂解。
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