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公开(公告)号：US12042497B2
公开(公告)日：2024-07-23
申请号：US17001741
申请日：2020-08-25
CPC分类号： A61K31/53 , A61P35/00 , A61K41/0038 , A61K31/53 , A61K2300/00
摘要： Provided are methods of treating a brain tumor in a patient in need thereof comprising administering to the patient a compound described herein and radiation therapy and/or one or more additional therapeutic agents.
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公开(公告)号：US11844758B2
公开(公告)日：2023-12-19
申请号：US17158867
申请日：2021-01-26
发明人： Zenon Konteatis , Janeta Popovici-Muller , Jeremy Travins , Robert Zahler , Zhenwei Cai , Ding Zhou
IPC分类号： A61K31/53 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
CPC分类号： A61K31/53 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
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公开(公告)号：US11419859B2
公开(公告)日：2022-08-23
申请号：US15767813
申请日：2016-10-14
发明人： Samuel V. Agresta
IPC分类号： A61K31/444 , A61K31/704 , A61K31/7068 , C07H19/09 , C07H15/252 , C07D403/14 , A61P35/02 , A61K31/136 , A61K31/7048
摘要： Provided are methods and compositions for treating acute myelogenous leukemia (AML) in patients carrying an IDH1 mutation using an inhibitor of a mutant IDH1 enzyme, (S)—N—((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide in combination with cytarabine and doxorubicin or idarubicin as an induction therapy and either cytarabine or a combination of combination of mitoxantrone and etoposide as consolidation therapy.
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公开(公告)号：US20220000878A1
公开(公告)日：2022-01-06
申请号：US17318606
申请日：2021-05-12
发明人： Bin Wu , Sung Eun Choe
IPC分类号： A61K31/53 , C07D401/14 , C07D251/18 , C07D251/52 , A61P35/02 , A61K31/166 , A61K31/4184 , A61K31/444 , A61K31/4523 , A61K31/519 , A61K45/06 , C12Q1/6886
摘要： Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation or IDH2 mutation.
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5.发明公开公开(公告)号：US20240343705A1
公开(公告)日：2024-10-17
申请号：US18504859
申请日：2023-11-08
发明人： Benjamin S. Lane , Chong-Hui Gu
IPC分类号： C07D401/04 , A61K45/06
CPC分类号： C07D401/04 , A61K45/06 , C07B2200/13
摘要： Provided are solid forms of a compound useful for treating cancer, pharmaceutical compositions thereof, and methods of treating cancer comprising administering the solid forms described herein to a patient in need thereof.
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公开(公告)号：US20240325401A1
公开(公告)日：2024-10-03
申请号：US18740374
申请日：2024-06-11
CPC分类号： A61K31/53 , A61P35/00 , A61K41/0038
摘要： Provided are methods of treating a brain tumor in a patient in need thereof comprising administering to the patient a compound described herein and radiation therapy and/or one or more additional therapeutic agents.
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公开(公告)号：US12064436B2
公开(公告)日：2024-08-20
申请号：US16619526
申请日：2018-06-12
IPC分类号： C07D401/04 , A61K31/53 , A61K45/06 , A61P35/00 , A61K41/00
CPC分类号： A61K31/53 , A61P35/00 , A61K41/0038 , A61K31/53 , A61K2300/00
摘要： Provided are methods of treating a brain tumor in a patient in need thereof comprising administering to the patient a compound described herein and radiation therapy and/or one or more additional therapeutic agents.
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公开(公告)号：USRE49934E1
公开(公告)日：2024-04-23
申请号：US17689209
申请日：2022-03-08
发明人： Zenon D. Konteatis , Zhihua Sui , Jeremy M. Travins , Zhixiong Ye
IPC分类号： C07D487/04 , C07D519/00 , C07F9/6561
CPC分类号： C07D487/04 , C07D519/00 , C07F9/6561
摘要： The present disclosure provides MAT2A inhibitor compounds that are useful as therapeutic agents for treating malignancies, and wherein the compounds conform to general formula (IA):
wherein RA, RB, RC, RD, and RE are defined herein.-
公开(公告)号：US20240041892A1
公开(公告)日：2024-02-08
申请号：US18479185
申请日：2023-10-02
IPC分类号： A61K31/53 , C07D401/04 , A61K9/00 , A61K45/06 , C07D401/14
CPC分类号： A61K31/53 , C07D401/04 , A61K9/0019 , A61K45/06 , A61K9/0053 , C07D401/14
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a purified compound described herein.
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公开(公告)号：US20230285364A1
公开(公告)日：2023-09-14
申请号：US18012136
申请日：2021-06-23
发明人： John Coco , Joshua Murtie , Danielle Ulanet
IPC分类号： A61K31/4192 , A61K31/635 , A61K31/7068 , A61K31/706 , A61P35/02 , A61P35/00
CPC分类号： A61K31/4192 , A61K31/635 , A61K31/706 , A61K31/7068 , A61P35/00 , A61P35/02
摘要： Provided herein are method of treating cancers using a first anti-cancer agent and at least one second anti-cancer agent, wherein the first anti-cancer agent is represented by Formula (I): or a pharmaceutically acceptable salt thereof. Compositions comprising the disclosed first anti-cancer agent and at least one second anti-cancer agent are also provided.
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