公开(公告)号：US11142542B2

公开(公告)日：2021-10-12

申请号：US16981986

申请日：2019-04-24

Applicant: Zhejiang Nhu Company Ltd. ,  Shandong Nhu Fine Chemical Science and Technology Company Ltd.

Inventor： Yougui Zhou ,  Jiang Cai ,  Kaifeng Ma ,  Yugang Wang ,  Xiaoqiao Wei ,  Yunhan Yang

IPC: C07H1/06 ,  C07H5/02

Abstract: A method for synthesizing sucrose-6-ester includes: (a) in the presence of a polar aprotic solvent, contacting an organic phosphine compound represented by formula I with sucrose and an organic tin compound; (b) removing water to obtain a reaction liquid containing a tin-sucrose adduct; and (c) contacting the reaction liquid containing the tin-sucrose adduct with an acid anhydride compound to prepare a sucrose-6-ester. In formula I, R1, R2, and R3 each are a linear or branched alkyl having 1 to 20 carbon atoms, a cycloalkyl having 3 to 10 carbon atoms, or an aryl having 6 to 10 carbon atoms; moreover, the R1, R2, and R3 are identical groups, partially identical groups, or different groups from each other. According to the method, the reaction conversion rate and selectivity are greatly improved; moreover, it is easy to realize industrial application.

公开(公告)号：USD1013533S1

公开(公告)日：2024-02-06

申请号：US35515274

申请日：2022-09-13

Applicant: ZHEJIANG NHU COMPANY LTD. ,  HEILONGJIANG NHU BIOTECHNOLOGY COMPANY LTD. ,  SHANGYU NHU BIO-CHEM CO., LTD. ,  SHANDONG NHU FINE CHEMICAL SCIENCE AND TECHNOLOGY COMPANY LTD. ,  XINCHANG NHU VITAMINS COMPANY LTD.

Designer： Liangang Shi ,  Xiujuan Lei

Abstract: 1. Bag packaging
1.1 : Front;
1.2 : Back;
1.3 : Left;
1.4 : Right;
1.5 : Top;
1.6 : Bottom;
1.7 : Reference view (unfolded status);
The broken lines showing of portions of the bag packaging is included for the purpose of illustrating environmental structure and forms no part of the claimed design.

公开(公告)号：US20210002317A1

公开(公告)日：2021-01-07

申请号：US16981986

申请日：2019-04-24

Applicant: Zhejiang Nhu Company Ltd. ,  Shandong Nhu Fine Chemical Science and Technology Company Ltd.

Inventor： Yougui ZHOU ,  Jiang CAI ,  Kaifeng MA ,  Yugang WANG ,  Xiaoqiao WEI ,  Yunhan YANG

IPC: C07H1/06

Abstract: A method for synthesizing sucrose-6-ester includes: (a) in the presence of a polar aprotic solvent, contacting an organic phosphine compound represented by formula I with sucrose and an organic tin compound; (b) removing water to obtain a reaction liquid containing a tin-sucrose adduct; and (c) contacting the reaction liquid containing the tin-sucrose adduct with an acid anhydride compound to prepare a sucrose-6-ester. In formula I, R1, R2, and R3 each are a linear or branched alkyl having 1 to 20 carbon atoms, a cycloalkyl having 3 to 10 carbon atoms, or an aryl having 6 to 10 carbon atoms; moreover, the R1, R2, and R3 are identical groups, partially identical groups, or different groups from each other. According to the method, the reaction conversion rate and selectivity are greatly improved; moreover, it is easy to realize industrial application.

公开(公告)号：US11180440B2

公开(公告)日：2021-11-23

申请号：US16954774

申请日：2018-11-30

Applicant: Zhejiang Nhu Company Ltd. ,  Zhejiang University ,  Shandong Nhu Amino Acid Co., Ltd. ,  Shandong Nhu Fine Chemical Science and Technology Company Ltd.

Inventor： Zhirong Chen ,  Jianyong Mao ,  Baishan Hu ,  Guanbing Li ,  Haoran Li ,  Yu Wang ,  Yingkuo Yang ,  Qing Liu ,  Jiyu Tang ,  Weiyong Chen

IPC: C07C209/52 ,  B01J23/78 ,  B01J35/04 ,  C07C209/48

Abstract: The present disclosure relates to a method for preparing isophorone diamine by means of a hydrogenation reduction of isophorone nitrile imine. The hydrogenation reduction is continuously carried out in a multi-stage bubble column reactor loaded with a supported alkaline cobalt-based catalyst, wherein isophorone nitrile imine is successively in countercurrent contact with hydrogen in each stage of the reactor to carry out a hydrogenation reduction reaction, so as to obtain the isophorone diamine. The preparation method solves the problem of back-mixing, and further improves the conversion rate and the cis/trans ratio of the product.

公开(公告)号：US20210087133A1

公开(公告)日：2021-03-25

申请号：US16954774

申请日：2018-11-30

Applicant: Zhejiang Nhu Company Ltd. ,  Zhejiang University ,  Shandong Nhu Amino Acid Co., Ltd. ,  Shandong Nhu Fine Chemical Science and Technology Company Ltd.

Inventor： Zhirong CHEN ,  Jianyong MAO ,  Baishan HU ,  Guanbing LI ,  Haoran LI ,  Yu WANG ,  Yingkuo YANG ,  Qing LIU ,  Jiyu TANG ,  Weiyong CHEN

IPC: C07C209/52 ,  C07C209/48 ,  B01J23/78 ,  B01J35/04

Abstract: The present disclosure relates to a method for preparing isophorone diamine by means of a hydrogenation reduction of isophorone nitrile imine. The hydrogenation reduction is continuously carried out in a multi-stage bubble column reactor loaded with a supported alkaline cobalt-based catalyst, wherein isophorone nitrile imine is successively in countercurrent contact with hydrogen in each stage of the reactor to carry out a hydrogenation reduction reaction, so as to obtain the isophorone diamine. The preparation method solves the problem of back-mixing, and further improves the conversion rate and the cis/trans ratio of the product.