公开(公告)号：US20210087133A1

公开(公告)日：2021-03-25

申请号：US16954774

申请日：2018-11-30

申请人： Zhejiang Nhu Company Ltd. ,  Zhejiang University ,  Shandong Nhu Amino Acid Co., Ltd. ,  Shandong Nhu Fine Chemical Science and Technology Company Ltd.

发明人： Zhirong CHEN ,  Jianyong MAO ,  Baishan HU ,  Guanbing LI ,  Haoran LI ,  Yu WANG ,  Yingkuo YANG ,  Qing LIU ,  Jiyu TANG ,  Weiyong CHEN

IPC分类号： C07C209/52 ,  C07C209/48 ,  B01J23/78 ,  B01J35/04

摘要： The present disclosure relates to a method for preparing isophorone diamine by means of a hydrogenation reduction of isophorone nitrile imine. The hydrogenation reduction is continuously carried out in a multi-stage bubble column reactor loaded with a supported alkaline cobalt-based catalyst, wherein isophorone nitrile imine is successively in countercurrent contact with hydrogen in each stage of the reactor to carry out a hydrogenation reduction reaction, so as to obtain the isophorone diamine. The preparation method solves the problem of back-mixing, and further improves the conversion rate and the cis/trans ratio of the product.

公开(公告)号：US20230022196A1

公开(公告)日：2023-01-26

申请号：US17782904

申请日：2020-10-20

申请人： ZHEJIANG NHU CO., LTD. ,  SHANDONG NHU AMINO ACID CO., LTD. ,  ZHEJIANG UNIVERSITY

发明人： Zhirong CHEN ,  Hong YIN ,  Zhixuan WANG ,  Cong CHEN ,  Shuangshuang ZHANG ,  Yu WANG

IPC分类号： C12P13/12 ,  C07C319/26 ,  B01D9/00

摘要： The present disclosure relates to an additive used in a methionine preparation process, and a methionine preparation method. The additive provided by the present disclosure is a mixture containing components A, B, and C; component A has a structure represented by the following general formula (1); component B has a structure represented by the following general formula (2); component C is silicone oil; RCON(CH3)CH2CH2SO3Na (1). The methionine preparation method provided in the present invention comprises subjecting methionine to crystallization and/or recrystallization in the presence of the additive provided by the present disclosure. The additive provided by the present disclosure results in uniform emulsification, has good stability, can be used stably for a long time, and is suitable for a continuous crystallization process. The prepared methionine crystal has a good crystal form, a large bulk density, and good flowability. In addition, according to the methionine preparation method of the present disclosure, a crystallization system can operate continuously and stably for a long time without obvious foaming, and the crystallization process of the methionine product can proceed smoothly.

公开(公告)号：US20210324391A1

公开(公告)日：2021-10-21

申请号：US17271356

申请日：2019-05-31

申请人： ZHEJIANG NHU COMPANY LTD. ,  HEILONGJIANG NHU BIOTECHNOLOGY COMPANY TLD. ,  SHANGYU NHU BIOLOGICAL CHEMICAL CO., LTD. ,  ZHEJIANG UNIVERSITY

发明人： Hongwei Yu ,  Shenfeng YUAN ,  Yongqiang ZHU ,  Kai YU ,  Zhirong CHEN ,  Yong LI ,  Guisheng QIU ,  Xiaoqing LIU

IPC分类号： C12N15/74 ,  C07K14/245 ,  C12P7/66 ,  C12N1/20

摘要： A recombinant microorganism, a preparation method thereof and its application in the production of coenzyme Q10. Specifically, the present disclosure provides a method of exogenously introducing a gene encoding the global regulatory protein irrE to construct a recombinant microorganism. This recombinant microorganism is suitable for producing coenzyme Q10 by fermentation method, and is particularly suitable for producing oxidized coenzyme Q10. The recombinant microorganism of the present disclosure has stress resistance, and has good tolerance against harsh environments including high osmotic pressure and high redox potential, thus making it possible to significantly increase the yield of coenzyme Q10, especially the yield of oxidized coenzyme Q10.

公开(公告)号：US20200347186A1

公开(公告)日：2020-11-05

申请号：US16957934

申请日：2018-07-12

申请人： ZHEJIANG NHU COMPANY LTD. ,  ZHEJIANG UNIVERSITY ,  ZHEJIANG NHU SPECIAL MATERIALS CO., LTD.

发明人： Woyuan LI ,  Hong YIN ,  Zhirong CHEN ,  Baishan HU ,  Guiyang ZHOU ,  Hangjun DENG ,  Ming LIAN ,  Xiongwei ZHANG ,  Qichuan LI ,  Jiang ZHAO

IPC分类号： C08G75/0254 ,  C08G75/029 ,  C08G75/0213

摘要： The present application relates to a method for extracting coenzyme Q10 and a phospholipid from a coenzyme Q10 fermentation bacterium powder. The method is characterized in that the fermentation bacterium powder of a coenzyme Q10 production strain is subjected to extraction with a mixed solvent of which the three-dimensional Hansen solubility parameter is between 21 and 23 (J/cm3)1/2 and the hydrogen bonding solubility parameter thereof is between 10 and 12 (J/cm3)1/2. The present invention can efficiently extract two products, namely coenzyme Q10 and a phospholipid, from the coenzyme Q10 fermentation bacterium powder; the process thereof is highly operable, easy to be industrialized, and can provide a product with high purity and yield, having great economic benefit.

公开(公告)号：US20230035875A1

公开(公告)日：2023-02-02

申请号：US17778276

申请日：2020-12-11

申请人： ZHEJIANG NHU COMPANY LTD. ,  ZHEJIANG UNIVERSITY ,  ZHEJIANG NHU SPECIAL MATERIALS CO., LTD.

发明人： Zhirong CHEN ,  Wenbin WU ,  Guiyang ZHOU ,  Ming FENG ,  Xingxing SHI ,  Tao MA ,  Zhichao FENG ,  Xiongwei ZHANG ,  Qing SUN ,  Yong XU

IPC分类号： C07C253/10

摘要： Provided are a method and device for preparing adiponitrile. The method of the present disclosure comprises the steps of a first hydrocyanation reaction, an isomerization reaction and a second hydrocyanation reaction, wherein online Raman spectroscopy is used for detecting the content of a specific component in the system; and the reaction conditions are regulated based on the detection results, so as to achieve precise control of the materials in each step of the reaction system. The method of the present disclosure can reduce an amount of butadiene, thereby reducing the subsequent energy consumption needed for recycling butadiene and equipment investment after reaction; by monitoring the content of hydrocyanic acid in real time, the residue of hydrocyanic acid is reduced to a lower level, and the operation safety and the stability of a catalyst during reaction are improved; and the loss of the catalyst is reduced.

公开(公告)号：US20220081394A1

公开(公告)日：2022-03-17

申请号：US17424454

申请日：2020-05-27

申请人： ZHEJIANG NHU COMPANY LTD. ,  ZHEJIANG UNIVERSITY ,  SHANGYU NHU BIO-CHEM CO., LTD. ,  ZHEJIANG NHU PHARMACEUTICAL CO., LTD.

发明人： Zhirong CHEN ,  Xianghua YAO ,  Junhua PENG ,  Yingxia PAN ,  Xiaoxiang HE ,  Songhua XU ,  Xiaodong WU ,  Xiang FANG

IPC分类号： C07C309/14 ,  B01J19/24 ,  B01J3/00 ,  B01D61/44 ,  B01D3/06

摘要： A method for preparing sodium taurine as a taurine intermediate is provided in the present disclosure. The method comprises the following steps: providing sodium hydroxyethyl sulfonate and an ammonia source; and placing the sodium hydroxyethyl sulfonate and the ammonia source in an aminolysis reactor for an aminolysis reaction to obtain a mixture containing sodium taurine as a taurine intermediate, wherein the molar ratio of ammonia in the ammonia source to the sodium hydroxyethyl sulfonate is greater than or equal to 25:1. A method for preparing taurine is further provided.

公开(公告)号：US20230063291A1

公开(公告)日：2023-03-02

申请号：US17793937

申请日：2021-04-29

申请人： ZHEJIANG NHU COMPANY LTD. ,  ZHEJIANG UNIVERSITY ,  XINCHANG NHU VITAMINS COMPANY LTD.

发明人： Jiandong LI ,  Zhirong CHEN ,  Lifang SHI ,  Guodong HUANG ,  Lishuang PAN ,  Hong YIN ,  Dan QIU ,  Qilei ZHANG ,  Xiaoyong ZHU ,  Xiang LIU ,  Lidan QI

IPC分类号： A23K40/30 ,  A23K20/105 ,  A23K20/147 ,  A23K20/158 ,  A23K20/163

摘要： A stable carotenoid microcapsule having high bioavailability and a preparation method therefor. The method includes the following steps: a) mixing carotenoid crystals with an organic solvent, and dissolving the mixture to obtain a carotenoid solution; b) introducing the carotenoid solution and a grease into a dispersion system to fully disperse carotenoid into the grease, and vaporizing the organic solvent to obtain a carotenoid-containing dispersion liquid; c) mixing the carotenoid-containing dispersion liquid and a protective colloid aqueous solution, and emulsifying the mixture to obtain an emulsion; and d) performing spray granulation and drying to obtain a carotenoid microcapsule.

公开(公告)号：US20220080400A1

公开(公告)日：2022-03-17

申请号：US17258439

申请日：2019-11-06

申请人： ZHEJIANG NHU COMPANY LTD. ,  ZHEJIANG UNIVERSITY ,  SHANDONG NHU PHARMACEUTICAL CO., LTD. ,  SHANDONG NHU VITAMIN CO., LTD.

发明人： Yong WANG ,  Zhe WANG ,  Yutong GONG ,  Lei WU ,  Lili YU ,  Haoran LI ,  Zhirong CHEN ,  Xiao MA ,  Jianyong MAO

IPC分类号： B01J31/22 ,  B01J37/04

摘要： A hydroformylation catalyst, a preparation method thereof and a use thereof. The hydroformylation catalyst including an active component and a carrier carrying the active component, wherein the active component includes a transition metal as a center atom, and a polyhydroxy aromatic ring group bonded to the transition metal; and the transition metal and the polyhydroxy aromatic ring groups are bonded by at least one of metal-hydroxyl coordination bond and at least one of metal-oxygen covalent bond, and the active component has at least one of the metal-hydroxyl coordination bond and at least one of the metal-oxygen covalent bond.

公开(公告)号：US20210009514A1

公开(公告)日：2021-01-14

申请号：US16955511

申请日：2018-07-12

申请人： ZHEJIANG NHU COMPANY LTD. ,  ZHEJIANG UNIVERSITY ,  ZHEJIANG NHU SPECIAL MATERIALS CO., LTD.

发明人： Zhirong CHEN ,  Woyuan LI ,  Hong YIN ,  Guíyang ZHOU ,  Haoran LI ,  Shuaifeng PAN ,  Ming LIAN ,  Guangde QIN ,  Qichuan LI

IPC分类号： C07C319/06

摘要： The present disclosure discloses a preparation method for 4-phenylthio-benzenethiol. The preparation method comprises the following steps: subjecting phenyl sulfide as a raw material to a halogenation reaction to obtain 4-halophenyl sulfide; subjecting the 4-halophenyl sulfide to a sulfhydrylation reaction to obtain a 4-phenylthio-phenylthiolate; and subjecting the 4-phenylthio-phenylthiolate to acidification. The preparation method of the present disclosure avoids the use of materials such as thiophenol which pollutes the environment, and realizes efficient recycling of the reaction materials, solvents, water and the like. The preparation method of the present disclosure is a green process for the synthesis of 4-phenylthio-phenylthiol without organic waste, waste acid and waste water discharge.

公开(公告)号：US20200070138A1

公开(公告)日：2020-03-05

申请号：US16669524

申请日：2019-10-31

申请人： ZHEJIANG NHU COMPANY LTD. ,  ZHEJIANG UNIVERSITY ,  SHANDONG NHU PHARMACEUTICAL CO., LTD. ,  SHANDONG NHU VITAMIN CO., LTD.

发明人： Yong WANG ,  Lili YU ,  Xiao MA ,  Jianyong MAO ,  Zhe WANG ,  Shanjun MAO ,  Jingsi TANG ,  Haoran LI ,  Zhirong CHEN

IPC分类号： B01J37/02 ,  B01J37/04 ,  B01J35/10 ,  C07D495/04 ,  C07C5/05 ,  B01J37/08 ,  B01J37/16 ,  B01J23/42 ,  B01J23/44 ,  B01J23/46

摘要： A composite catalyst includes a carrier and noble metal particles supported by the carrier, wherein the carrier is a nitrogen-doped porous carbon composite material having a plurality of passages. The nitrogen-doped porous carbon composite material can include a nitrogen-doped porous carbon material and a plurality of metal oxide particles. The plurality of metal oxide particles can be uniformly distributed in the nitrogen-doped porous carbon material. The plurality of metal oxide particles can be partially exposed through the plurality of passages. The noble metal particles can be tightly combined with the exposed metal oxide particles to achieve recombination. And the noble metal particles can be at least one of Pd metal particles, Pt metal particles, Ru metal particles, Rh metal particles, Ir metal particles, Au metal particles, or a combination thereof.