公开(公告)号：US20220362165A1

公开(公告)日：2022-11-17

申请号：US17770857

申请日：2020-10-21

申请人： Krunal RAVAL ,  Suresh BORSADIA ,  Hock S. TAN ,  Kalpana PATEL ,  SHINKEI THERAPEUTICS LLC

发明人： Krunal RAVAL ,  Suresh BORSADIA ,  Hock S. TAN ,  Kalpana PATEL

IPC分类号： A61K9/70 ,  A61K31/4745

摘要： Provided herein are compositions, delivery devices, and methods relating to the delivery of tetrabenazine and/or deuterated tetrabenazine, for example, continuous or substantially continuous delivery such as transdermal delivery, for the treatment of a hyperkinetic movement disorder. Also provided are transdermal delivery devices comprising tetrabenazine, a deuterated tetrabenazine, or a combination thereof, pharmaceutical compositions comprising tetrabenazine and/or a deuterated tetrabenazine, methods of preparing the same, and methods of using the same for example, for the treatment of a hyperkinetic movement disorder.

公开(公告)号：US20240216358A1

公开(公告)日：2024-07-04

申请号：US17915687

申请日：2021-03-29

申请人： SHINKEI THERAPEUTICS LLC

发明人： Suresh BORSADIA ,  Kalpana PATEL ,  Hock S. TAN ,  Krunal RAVAL

IPC分类号： A61K31/485 ,  A61K9/70 ,  A61K47/14 ,  A61K47/32

CPC分类号： A61K31/485 ,  A61K9/7061 ,  A61K9/7069 ,  A61K47/14 ,  A61K47/32

摘要： Provided herein are novel transdermal delivery devices (or patches) comprising dextromethorphan, pharmaceutical compositions comprising dextromethorphan, methods of preparation thereof, and methods of administering dextromethorphan transdermally. Also provided herein are methods of treating various diseases and disorders such as neurological diseases or disorders (e.g., PBA) using the transdermal delivery devices and/or pharmaceutical compositions herein.

公开(公告)号：US20210128490A1

公开(公告)日：2021-05-06

申请号：US17050230

申请日：2019-04-24

申请人： SHINKEI THERAPEUTICS LLC

发明人： Suresh BORSADIA ,  Kalpana PATEL ,  Hock S. TAN

IPC分类号： A61K9/70 ,  A61K31/4745 ,  A61K47/14 ,  A61K47/32 ,  A61K47/38 ,  A61K47/34

摘要： Provided herein are transdermal delivery devices comprising tetrabenazine, a deuterated tetrabenazine, or a combination thereof. Also provided herein are pharmaceutical compositions, such as adhesive compositions, comprising tetrabenazine, a deuterated tetrabenazine, or a combination thereof, for example, homogenously dispersed in an adhesive, such as a pressure sensitive adhesive. Further provided herein are methods of using the transdermal delivery devices or pharmaceutical compositions, for example, for treating a hyperkinetic movement disorder.