-
公开(公告)号：US20230002352A1
公开(公告)日：2023-01-05
申请号：US17760861
申请日：2020-09-18
申请人： Step Pharma S.A.S.
发明人： Andrew Novak , Abdul Quddus , David Cousin , Joseph Wrigglesworth , Emma Blackham , Geraint Jones , Lorna Duffy , Louise Birch , Pascal George , Saleh Ahmed
IPC分类号： C07D401/12 , C07D403/12 , C07D405/14 , C07D401/14
摘要： The invention provides a compound of formula (I): formula (I) and the use of such compounds as cytidine triphosphate synthase 1 inhibitors, particularly in the treatment or prophylaxis of disorders associated with cell proliferation.
-
公开(公告)号：US20220324837A1
公开(公告)日：2022-10-13
申请号：US17615873
申请日：2020-06-04
申请人： Step Pharma S.A.S.
发明人： Abdul Quddus , Andrew Novak , David Cousin , Emma Blackham , Geraint Jones , Joseph Wrigglesworth , Lorna Duffy , Louise Birch , Pascal George , Saleh Ahmed
IPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D239/42 , C07D405/04 , C07D401/04 , C07D239/38
摘要： Compounds of formula (I) as human cytidine triphosphate synthase 1 (CTPS1) inhibitors for the treatment of prolifera-tive diseases, such as e.g. cancer, such as e.g. leukemia and lymphoma, e.g. inflammatory skin diseases such as psoriasis, or e.g. multiple sclerosis. The present description discloses the synthesis and characterisa-tion of exemplary compounds as well as pharmacological data thereof (e.g. pages 64 to 80; examples; biological examples 1 and 2; e.g. compounds P140, P231 to P263; tables 1 to 10). Specific examples are e.g.: N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(methylsulfonami-N do) pyrimidin-4-yl)tetrahydro-2H-pyran-4-carboxamide (Formula (II)), or 1-(2-(cyclopropanesulfonamido)pyrimidin-4-yl)-N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)cyclohexane-1-carboxamide (Formula (III)).
-
公开(公告)号：US20210024507A1
公开(公告)日：2021-01-28
申请号：US16982641
申请日：2019-03-22
申请人： Step Pharma S.A.S.
发明人： Abdul Quddus , Andrew Novak , David Cousin , Emma Blackham , Geraint Jones , Joseph Wrigglesworth , Lorna Duffy , Louise Birch , Pascal George , Saleh Ahmed
IPC分类号： C07D405/14 , C07D401/12 , C07D403/12 , C07D401/14 , C07D239/42
摘要： Compounds of formula (I): and related aspects.
-
公开(公告)号：US20210002269A1
公开(公告)日：2021-01-07
申请号：US16767338
申请日：2018-11-11
申请人： STEP PHARMA S.A.S.
发明人： Abdul QUDDUS , Andrew Novak , David COUSIN , Elli CHATZOPOULOU , Emma BLACKHAM , Geraint JONES , Jennifer Thomas , Joesph WRIGGLESWORTH , Lorna DUFFY , Louise BIRCH , Pascal GEORGE , Saleh AHMED
IPC分类号： C07D417/14 , C07D277/52 , C07D417/12
摘要： Compounds of formula (I): (I) and related aspects.
-
公开(公告)号：US20230020663A1
公开(公告)日：2023-01-19
申请号：US17760886
申请日：2020-09-18
申请人： Step Pharma S.A.S.
发明人： Andrew Novak , Abdul Quddus , David Cousin , Joseph Wrigglesworth , Emma Blackham , Geraint Jones , Lorna Duffy , Louise Birch , Pascal George , Saleh Ahmed
IPC分类号： C07D401/12 , C07D403/12 , C07D405/14 , C07D401/14 , C07D239/42 , C07D417/12 , C07D277/54
摘要： The invention provides a compound of formula (I) and processes for the manufacture of such compounds, related intermediates, compositions comprising such compounds and the use of such compounds as cytidine triphosphate synthase 1 inhibitors, particularly in the treatment or prophylaxis of disorders associated with cell proliferation.
-
公开(公告)号：US11505547B2
公开(公告)日：2022-11-22
申请号：US16767379
申请日：2018-11-30
申请人： STEP PHARMA S.A.S.
发明人： Andrew Novak , Geraint Jones , Joseph Wrigglesworth , Lorna Duffy , Louise Birch , Pascal George
IPC分类号： C07D241/12 , C07D401/12 , C07D417/12 , C07D417/14 , C07D277/52 , C07D213/22 , C07D213/38 , A61K31/425 , A61P35/00 , A61P37/00
摘要： Compounds of formula (I) and related aspects.
-
公开(公告)号：US20240010645A1
公开(公告)日：2024-01-11
申请号：US18302259
申请日：2023-04-18
申请人： STEP PHARMA S.A.S.
发明人： Abdul QUDDUS , Andrew NOVAK , David COUSIN , Elli CHATZOPOULOU , Emma BLACKHAM , Geraint JONES , Jennifer THOMAS , Joesph WRIGGLESWORTH , Lorna DUFFY , Louise BIRCH , Pascal GEORGE , Saleh AHMED
IPC分类号： C07D417/14 , C07D277/52 , C07D417/12
CPC分类号： C07D417/14 , C07D277/52 , C07D417/12
摘要： Compounds of formula (I): (I) and related aspects.
-
公开(公告)号：US20210387965A1
公开(公告)日：2021-12-16
申请号：US17287137
申请日：2019-10-23
申请人： Step Pharma S.A.S.
发明人： Abdul Quddus , Andrew Novak , David Cousin , Emma Blackham , Geraint Jones , Joseph Wrigglesworth , Lorna Duffy , Louise Birch , Pascal George , Saleh Ahmed
IPC分类号： C07D401/14 , C07D405/14
摘要： Compounds of formula (I), and related aspects.
-
公开(公告)号：US20210380575A1
公开(公告)日：2021-12-09
申请号：US16767379
申请日：2018-11-30
申请人： STEP PHARMA S.A.S.
发明人： Andrew NOVAK , Geraint JONES , Joseph WRIGGLESWORTH , Lorna DUFFY , Louise BIRCH , Pascal GEORGE
IPC分类号： C07D417/12 , C07D277/52 , C07D417/14
摘要： Compounds of formula (I) and related aspects.
-
公开(公告)号：US11987573B2
公开(公告)日：2024-05-21
申请号：US17287137
申请日：2019-10-23
申请人： Step Pharma S.A.S.
发明人： Abdul Quddus , Emma Blackham
IPC分类号： C07D401/14 , A61P35/00 , C07D405/14
CPC分类号： C07D401/14 , A61P35/00 , C07D405/14
摘要： Compounds of formula (I), and related aspects.
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.013 秒)
