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公开(公告)号：US09145556B2
公开(公告)日：2015-09-29
申请号：US13085878
申请日：2011-04-13
CPC分类号： C12N15/113 , A61K31/713 , A61K47/50 , C12N15/111 , C12N2310/113 , C12N2310/141 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/332 , C12N2310/3515 , C12N2310/3519 , C12N2310/51 , C12N2310/531 , C12N2330/31
摘要： The invention relates generally to compositions and methods for inhibiting the function of target nucleic acids by sequence specific binding. The compositions and methods can be used for inhibition of micro RNAs and other relatively short non-coding RNAs.
摘要翻译： 本发明一般涉及通过序列特异性结合抑制靶核酸功能的组合物和方法。 组合物和方法可用于抑制微RNA和其他相对较短的非编码RNA。
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公开(公告)号：US20150166992A1
公开(公告)日：2015-06-18
申请号：US14564573
申请日：2014-12-09
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/713 , A61K47/50 , C12N15/111 , C12N2310/113 , C12N2310/141 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/332 , C12N2310/3515 , C12N2310/3519 , C12N2310/51 , C12N2310/531 , C12N2330/31
摘要： The invention relates generally to compositions and methods for inhibiting the function of target nucleic acids by sequence specific binding. The compositions and methods can be used for inhibition of micro RNAs and other relatively short non-coding RNAs.
摘要翻译： 本发明一般涉及通过序列特异性结合抑制靶核酸功能的组合物和方法。 组合物和方法可用于抑制微RNA和其他相对较短的非编码RNA。
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公开(公告)号：US20110251261A1
公开(公告)日：2011-10-13
申请号：US13085878
申请日：2011-04-13
CPC分类号： C12N15/113 , A61K31/713 , A61K47/50 , C12N15/111 , C12N2310/113 , C12N2310/141 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/332 , C12N2310/3515 , C12N2310/3519 , C12N2310/51 , C12N2310/531 , C12N2330/31
摘要： The invention relates generally to compositions and methods for inhibiting the function of target nucleic acids by sequence specific binding. The compositions and methods can be used for inhibition of micro RNAs and other relatively short non-coding RNAs.
摘要翻译： 本发明一般涉及通过序列特异性结合抑制靶核酸功能的组合物和方法。 组合物和方法可用于抑制微RNA和其他相对较短的非编码RNA。
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4.发明授权siRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAi, and stabilized forms thereof 有权用于减少RNAi中的靶外表型效应的siRNA序列非依赖性修饰形式及其稳定形式公开(公告)号：US08524681B2
公开(公告)日：2013-09-03
申请号：US12727336
申请日：2010-03-19
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2310/319 , C12N2310/321 , C12N2310/3231 , C12N2310/343 , C12N2320/53 , C12N2310/3521
摘要： Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided herein reduce off-target effects in RNA interference of endogenous genes. Further modification formatted siRNAs are demonstrated to be stabilized to nuclease-rich environments. Unexpectedly, increasing or maintaining strand bias, while necessary to maintain potency for endogenous RNA interference, is not sufficient for reducing off-target effects in cell biology assays.
摘要翻译： 提供了具有修饰的核苷酸的修饰形式用于siRNA。 具有修饰形式的短干扰RNA和本文提供的经修饰的核苷酸减少RNA干扰内源基因的脱靶效应。 证明进一步修饰格式化的siRNA被稳定到富含核酸酶的环境中。 意外的是，增加或维持链偏倚，同时必需保持内源RNA干扰的效力，不足以减少细胞生物学测定中的脱靶效应。
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5.发明申请SiRNA Sequence-Independent Modification Formats for Reducing Off-Target Phenotypic Effects in RNAi, and Stabilized Forms Thereof 有权用于减少RNAi中的非目标表型效应的siRNA序列非依赖性修饰形式及其稳定形式公开(公告)号：US20100222414A1
公开(公告)日：2010-09-02
申请号：US12727336
申请日：2010-03-19
IPC分类号： A61K31/7105 , C07H21/00 , C07H21/02 , C12N5/071 , A61P43/00
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2310/319 , C12N2310/321 , C12N2310/3231 , C12N2310/343 , C12N2320/53 , C12N2310/3521
摘要： Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided herein reduce off-target effects in RNA interference of endogenous genes. Further modification formatted siRNAs are demonstrated to be stabilized to nuclease-rich environments. Unexpectedly, increasing or maintaining strand bias, while necessary to maintain potency for endogenous RNA interference, is not sufficient for reducing off-target effects in cell biology assays.
摘要翻译： 提供了具有修饰的核苷酸的修饰形式用于siRNA。 具有修饰形式的短干扰RNA和本文提供的经修饰的核苷酸减少RNA干扰内源基因的脱靶效应。 证明进一步修饰格式化的siRNA被稳定到富含核酸酶的环境中。 意外的是，增加或维持链偏倚，同时必需保持内源性RNA干扰的效力，不足以减少细胞生物学测定中的脱靶效应。
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