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公开(公告)号：US20100144837A1
公开(公告)日：2010-06-10
申请号：US12625871
申请日：2009-11-25
IPC分类号： A61K31/7088 , C07H21/04 , A61P35/00
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/4412 , A61K2039/505 , C07K14/47 , C07K16/40 , C12N9/0071 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
摘要： The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
摘要翻译： 本发明的特征在于通过使来自哺乳动物的体液与结合人天冬氨酰基（天冬酰胺酰基）β-羟化酶（HAAH））多肽的抗体和通过抑制HAAH来治疗恶性肿瘤的方法接触来诊断哺乳动物的恶性肿瘤的方法。
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公开(公告)号：US20100136581A1
公开(公告)日：2010-06-03
申请号：US12625729
申请日：2009-11-25
IPC分类号： G01N33/53
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/4412 , A61K2039/505 , C07K14/47 , C07K16/40 , C12N9/0071 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
摘要： The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
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公开(公告)号：US20100093002A1
公开(公告)日：2010-04-15
申请号：US11974076
申请日：2007-10-10
IPC分类号： G01N33/574 , G01N33/53
CPC分类号： A61K31/00 , A61K31/4412 , A61K2039/505 , C07K14/47 , C07K16/40 , C12N9/0071 , C12N15/1137 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
摘要： The invention features a method of inhibiting tumor growth and/or tumor invasiveness in a mammal by administering to a mammal a compound (e.g., an antagonistic antibody) which inhibits expression or enzymatic activity of human aspartyl (asparaginyl) beta-hydroxylase (HAAH). The invention also features a method for diagnosing the growth of a malignant neoplasm (e.g., pancreatic cancer) in a mammal by contacting a tissue or bodily fluid from the mammal with an antibody which binds to a HAAH polypeptide under conditions sufficient to form an antigen-antibody complex and/or detecting the antigen-antibody complex.
摘要翻译： 本发明的特征在于通过向哺乳动物施用抑制人天冬氨酰（天冬酰胺酰基）β-羟化酶（HAAH）的表达或酶活性的化合物（例如拮抗性抗体）来抑制哺乳动物的肿瘤生长和/或肿瘤侵袭的方法。 本发明还具有通过使哺乳动物的组织或体液与足以形成抗原决定簇的条件与HAAH多肽结合的抗体接触来诊断哺乳动物的恶性肿瘤（例如胰腺癌）的生长的方法， 抗体复合物和/或检测抗原 - 抗体复合物。
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公开(公告)号：US06835370B2
公开(公告)日：2004-12-28
申请号：US09859604
申请日：2001-05-17
IPC分类号： A61K5110
CPC分类号： C07K16/40 , A61K31/00 , A61K31/4412 , A61K47/6865 , A61K49/16 , A61K51/1093 , A61K2039/505 , C07K14/47 , C12N9/0071 , C12N15/1137 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
摘要： The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide. Methods of immunization to generate an HAAH-specific immune response are also within the invention.
摘要翻译： 本发明的特征在于通过使哺乳动物的细胞或体液与结合人天冬氨酰（天冬酰胺酰基）β-羟化酶（HAAH）多肽的抗体接触来诊断和抑制哺乳动物恶性肿瘤生长的方法。 免疫产生HAAH特异性免疫应答的方法也在本发明的范围内。
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5.发明授权Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid 有权使用AD7c-NTP核酸的阿尔茨海默病非转基因非人模型公开(公告)号：US06770797B2
公开(公告)日：2004-08-03
申请号：US09872968
申请日：2001-06-01
IPC分类号： G01N3300
CPC分类号： C07K14/4711 , A01K67/0275 , A01K2267/0312 , A61K48/00 , C12N15/67
摘要： The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death.
摘要翻译： 本发明的特征在于阿尔茨海默病的非转基因模型，用于在哺乳动物中诱导延长的体内基因表达的方法，以及抑制阿尔茨海默病相关神经元细胞死亡的方法。
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公开(公告)号：US06797696B2
公开(公告)日：2004-09-28
申请号：US09903199
申请日：2001-07-11
IPC分类号： A61K3800
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/4412 , A61K2039/505 , C07K14/47 , C07K16/40 , C12N9/0071 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
摘要： The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
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公开(公告)号：US20110124016A1
公开(公告)日：2011-05-26
申请号：US12955435
申请日：2010-11-29
IPC分类号： G01N33/574
CPC分类号： A61K31/00 , A61K31/4412 , A61K2039/505 , C07K14/47 , C07K16/40 , C12N9/0071 , C12N15/1137 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
摘要： The invention features a method of inhibiting tumor growth and/or tumor invasiveness in a mammal by administering to a mammal a compound (e.g., an antagonistic antibody) which inhibits expression or enzymatic activity of human aspartyl (asparaginyl) beta-hydroxylase (HAAH). The invention also features a method for diagnosing the growth of a malignant neoplasm (e.g., pancreatic cancer) in a mammal by contacting a tissue or bodily fluid from the mammal with an antibody which binds to a HAAH polypeptide under conditions sufficient to form an antigen-antibody complex and/or detecting the antigen-antibody complex.
摘要翻译： 本发明的特征在于通过向哺乳动物施用抑制人天冬氨酰（天冬酰胺酰基）β-羟化酶（HAAH）的表达或酶活性的化合物（例如拮抗性抗体）来抑制哺乳动物的肿瘤生长和/或肿瘤侵袭的方法。 本发明还具有通过使哺乳动物的组织或体液与足以形成抗原决定簇的条件与HAAH多肽结合的抗体接触来诊断哺乳动物的恶性肿瘤（例如胰腺癌）的生长的方法， 抗体复合物和/或检测抗原 - 抗体复合物。
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8.发明授权Increased and sustained in vivo gene expression using a nucleic acid, histone and amphipathic compound composition 有权使用核酸，组蛋白和两亲化合物组合物增加和持续的体内基因表达公开(公告)号：US07319094B2
公开(公告)日：2008-01-15
申请号：US10910173
申请日：2004-08-02
CPC分类号： C07K14/4711 , A01K67/0275 , A01K2267/0312 , A61K48/00 , C12N15/67
摘要： The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death.
摘要翻译： 本发明的特征在于阿尔茨海默病的非转基因模型，用于在哺乳动物中诱导延长的体内基因表达的方法，以及抑制阿尔茨海默病相关神经元细胞死亡的方法。
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公开(公告)号：US07094556B2
公开(公告)日：2006-08-22
申请号：US09903023
申请日：2001-07-11
IPC分类号： G01N33/53
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/4412 , A61K2039/505 , C07K14/47 , C07K16/40 , C12N9/0071 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
摘要： The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
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公开(公告)号：US06815415B2
公开(公告)日：2004-11-09
申请号：US09903063
申请日：2001-07-11
IPC分类号： A61K3800
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/4412 , A61K2039/505 , C07K14/47 , C07K16/40 , C12N9/0071 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
摘要： The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
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