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1.发明申请BISPECIFIC, BIVALENT ANTI-VEGF/ANTI-ANG-2 ANTIBODIES 有权BISPECIFIC，BIVALENT ANTI-VEGF / ANTI-ANG-2 ANTIBODIES公开(公告)号：US20110236388A1
公开(公告)日：2011-09-29
申请号：US13071127
申请日：2011-03-24
申请人： Monika Baehner , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Kay-Gunnar Stubenrauch , Markus Thomas
发明人： Monika Baehner , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Kay-Gunnar Stubenrauch , Markus Thomas
IPC分类号： A61K39/395 , C07K16/22 , C07H21/00 , A61P9/00 , A61P35/00 , C12N15/63 , C12P21/02 , C12N5/10 , C12N1/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/3015 , C07K16/3046 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/56 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to bispecific, bivalent antibodies against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人血管内皮生长因子（VEGF / VEGF-A）和针对人血管生成素-2（ANG-2）的双特异性二价抗体，其生产方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20100322934A1
公开(公告)日：2010-12-23
申请号：US12786477
申请日：2010-05-25
申请人： Sabine Imhof-Jung , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer
发明人： Sabine Imhof-Jung , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer
IPC分类号： A61K39/395 , C07K16/18 , C12P21/00 , A61P35/00 , C12N5/10
CPC分类号： C07K16/468 , C07K16/22 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to bispecific, tetravalent antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及双特异性，四价抗原结合蛋白，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US08703130B2
公开(公告)日：2014-04-22
申请号：US13570333
申请日：2012-08-09
申请人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20100316645A1
公开(公告)日：2010-12-16
申请号：US12780971
申请日：2010-05-17
申请人： Sabine Imhof-Jung , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer
发明人： Sabine Imhof-Jung , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00 , C12P21/00 , C12N5/07
CPC分类号： C07K16/22 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to bispecific antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及双特异性抗原结合蛋白，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US09676845B2
公开(公告)日：2017-06-13
申请号：US12780971
申请日：2010-05-17
申请人： Sabine Imhof-Jung , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer
发明人： Sabine Imhof-Jung , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer
IPC分类号： A61K39/395 , C07K16/22 , C07K16/46
CPC分类号： C07K16/22 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to bispecific antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US08703132B2
公开(公告)日：2014-04-22
申请号：US12786477
申请日：2010-05-25
申请人： Sabine Imhof-Jung , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer
发明人： Sabine Imhof-Jung , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer
IPC分类号： A61K39/395
CPC分类号： C07K16/468 , C07K16/22 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to bispecific, tetravalent antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及双特异性，四价抗原结合蛋白，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20120321627A1
公开(公告)日：2012-12-20
申请号：US13570333
申请日：2012-08-09
申请人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： A61K39/395 , A61P9/00 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20120309940A1
公开(公告)日：2012-12-06
申请号：US13464878
申请日：2012-05-04
CPC分类号： C07K16/18 , C07K16/00 , C07K16/32 , C07K16/468 , C07K2317/41 , C07K2317/52 , C07K2318/20 , C07K2319/00 , C07K2319/21 , C07K2319/30
摘要： Herein are reported glycosylated repeat-motif-molecule conjugate of the following formula: (repeat-motif-molecule−linkern)m−conjugation partner−(linkero−repeat-motif-molecule)p, wherein n and o are independently of each other and independently for each value of m and p integer values of 0 or 1, and m and p are independently of each other integer values of 0 or 1 or 2 or 3 or 4 or 5 or 6 or 7, and wherein the repeat-motif-molecule conjugate comprises at least one oligosaccharide attached to a glycosylation site. Also reported are encoding nucleic acids and method for producing these repeat-motif-conjugates in mammalian cells.
摘要翻译： 本文报导了下式的糖基化重复 - 基序 - 分子结合物：（重复 - 基序 - 分子连接）m-缀合配偶体（连接重复 - 基序 - 分子）p，其中n和o彼此独立地为 对于m和p整数值为0或1的每个值独立地为m和p彼此独立地为0或1或2或3或4或5或6或7的整数，并且其中重复 - 分子结合物包含至少一个连接于糖基化位点的寡糖。 还报道了编码核酸和在哺乳动物细胞中产生这些重复基序缀合物的方法。
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公开(公告)号：US20100111967A1
公开(公告)日：2010-05-06
申请号：US12572289
申请日：2009-10-02
申请人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： C07K16/22 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20190135901A9
公开(公告)日：2019-05-09
申请号：US13464878
申请日：2012-05-04
摘要： Herein are reported glycosylated repeat-motif-molecule conjugate of the following formula: (repeat-motif-molecule−linkern)m−conjugation partner−(linkero−repeat-motif-molecule)p, wherein n and o are independently of each other and independently for each value of m and p integer values of 0 or 1, and m and p are independently of each other integer values of 0 or 1 or 2 or 3 or 4 or 5 or 6 or 7, and wherein the repeat-motif-molecule conjugate comprises at least one oligosaccharide attached to a glycosylation site. Also reported are encoding nucleic acids and method for producing these repeat-motif-conjugates in mammalian cells.
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