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    COMPOSITION FOR THE PREVENTION AND TREATMENT OF POSTMENOPAUSAL SYNDROME CONTAINING EXTRACTS OR FRACTIONS OF ACERIPHYLLUM ROSSII AS AN EFFECTIVE INGREDIENT
    1.
    发明申请
    COMPOSITION FOR THE PREVENTION AND TREATMENT OF POSTMENOPAUSAL SYNDROME CONTAINING EXTRACTS OR FRACTIONS OF ACERIPHYLLUM ROSSII AS AN EFFECTIVE INGREDIENT 有权
    用于预防和治疗含有ACERIPHLLUM ROSSII作为有效成分的提取物或分泌物的口服综合征的组合物

    公开(公告)号：US20110206784A1

    公开(公告)日：2011-08-25

    申请号：US12829962

    申请日：2010-07-02

    Applicant: Chu Won NHO ,  Na Ra JEON ,  Kyung Su KANG ,  Saet Byoul LEE ,  Ji Hye YOO ,  Suk Woo KANG ,  Byung Hun UM ,  Cheol-Ho PAN

    Inventor： Chu Won NHO ,  Na Ra JEON ,  Kyung Su KANG ,  Saet Byoul LEE ,  Ji Hye YOO ,  Suk Woo KANG ,  Byung Hun UM ,  Cheol-Ho PAN

    IPC: A61K36/185 ,  A61P7/02 ,  A61P19/10 ,  C12N5/07 ,  C12N5/073

    CPC classification number: A61K36/185

    Abstract: The present invention relates to a method for the prevention and treatment of postmenopausal syndrome containing the step of administering a pharmaceutically effective dose of the Aceriphyllum rossii or its fractions to a subject. The present inventors confirmed that the Aceriphyllum rossii extract or its fractions of the invention prepared by using water, alcohol or a mixed solvent thereof could promote the expression of the promoter containing estrogen responsive element (ERE) and accelerated the growth of MCF-7, the human breast tissue originated cell line, suggesting that they had estrogen activity. The inventors further confirmed that the extract or its fractions of the invention had the effect of promoting osteocyte differentiation, so that they could be effectively used for the prevention and treatment of postmenopausal syndrome such as hot flush, osteoporosis and phlebothrombosis caused by estrogen deficiency.

    Abstract translation: 本发明涉及一种预防和治疗绝经后综合征的方法，其包括向受试者施用药学有效剂量的Aceriphyllum rossii或其级分的步骤。 本发明人证实，通过使用水，醇或其混合溶剂制备的本发明的Aceriphyllum rossii提取物或其级分可以促进含有雌激素反应元件（ERE）的启动子的表达并加速MCF-7的生长， 人乳腺组织起源于细胞系，表明它们具有雌激素活性。 本发明人进一步确认本发明的提取物或其成分具有促进骨细胞分化的作用，从而可有效地用于预防和治疗由雌激素缺乏引起的热冲洗，骨质疏松症和血栓形成等绝经后综合征。

    Composition for the prevention and treatment of postmenopausal syndrome containing extracts or fractions of Aceriphyllum rossii as an effective ingredient
    4.
    发明授权
    Composition for the prevention and treatment of postmenopausal syndrome containing extracts or fractions of Aceriphyllum rossii as an effective ingredient 有权
    用于预防和治疗含有Aceriphyllum rossii的提取物或部分的绝经后综合征作为有效成分的组合物

    公开(公告)号：US08524287B2

    公开(公告)日：2013-09-03

    申请号：US12829962

    申请日：2010-07-02

    Applicant: Chu Won Nho ,  Na Ra Jeon ,  Kyung Su Kang ,  Saet Byoul Lee ,  Ji Hye Yoo ,  Suk Woo Kang ,  Byung Hun Um ,  Cheol-Ho Pan

    Inventor： Chu Won Nho ,  Na Ra Jeon ,  Kyung Su Kang ,  Saet Byoul Lee ,  Ji Hye Yoo ,  Suk Woo Kang ,  Byung Hun Um ,  Cheol-Ho Pan

    IPC: A61K36/00

    CPC classification number: A61K36/185

    Abstract: The present invention relates to a method for the prevention and treatment of postmenopausal syndrome containing the step of administering a pharmaceutically effective dose of the Aceriphyllum rossii or its fractions to a subject. The present inventors confirmed that the Aceriphyllum rossii extract or its fractions of the invention prepared by using water, alcohol or a mixed solvent thereof could promote the expression of the promoter containing estrogen responsive element (ERE) and accelerated the growth of MCF-7, the human breast tissue originated cell line, suggesting that they had estrogen activity. The inventors further confirmed that the extract or its fractions of the invention had the effect of promoting osteocyte differentiation, so that they could be effectively used for the prevention and treatment of postmenopausal syndrome such as hot flush, osteoporosis and phlebothrombosis caused by estrogen deficiency.

    Abstract translation: 本发明涉及一种预防和治疗绝经后综合征的方法，其包括向受试者施用药学有效剂量的Aceriphyllum rossii或其级分的步骤。 本发明人证实，通过使用水，醇或其混合溶剂制备的本发明的Aceriphyllum rossii提取物或其级分可以促进含有雌激素反应元件（ERE）的启动子的表达并加速MCF-7的生长， 人乳腺组织起源于细胞系，表明它们具有雌激素活性。 本发明人进一步确认本发明的提取物或其成分具有促进骨细胞分化的作用，从而可有效地用于预防和治疗由雌激素缺乏引起的热冲洗，骨质疏松症和血栓形成等绝经后综合征。

    Pharmaceutical composition containing daurinol for the prevention and treatment of cancers
    5.
    发明授权
    Pharmaceutical composition containing daurinol for the prevention and treatment of cancers 有权
    含有劳伦林用于预防和治疗癌症的药物组合物

    公开(公告)号：US08227512B2

    公开(公告)日：2012-07-24

    申请号：US12529828

    申请日：2007-10-10

    Applicant: Chu Won Nho ,  Kyung Su Kang ,  Saet Byoul Lee ,  Batsuren Dulamjav ,  Tunsag Jigjidsuren

    Inventor： Chu Won Nho ,  Kyung Su Kang ,  Saet Byoul Lee ,  Batsuren Dulamjav ,  Tunsag Jigjidsuren

    IPC: A61K31/35 ,  A61P35/00

    CPC classification number: A61K36/75 ,  A61K31/343

    Abstract: The present invention relates to a pharmaceutical composition for the prevention and treatment of cancer comprising daurinol as an active ingredient, more precisely a pharmaceutical composition for the prevention and treatment of cancer comprising daurinol isolated from the medicinal plant of Mongolia, Haplophyllum dauricum or Haplophyllum cappadocicum, as an active ingredient. Daurinol can selectively block the S phase of cancer cell cycle to disturb the cycle and induce apoptosis stepwise, resulting in anticancer effect. Therefore, daurinol of the present invention can be used as a positive control chemical in the research and development field of cancer biology especially for cancer therapy and prevention. Daurinol also can be a promising candidate for a novel cell cycle blocker and a novel apoptosis inducer which could be effectively used for the prevention and treatment of cancer in the end.

    Abstract translation: 本发明涉及一种用于预防和治疗癌症的药物组合物，其包含戴尼醇作为活性成分，更确切地说，涉及一种用于预防和治疗癌症的药物组合物，其包含从蒙古药用植物，Haplophyllum dauricum或Haplophyllum cappadocicum分离的多萝醇， 作为活性成分。 Daurinol可以选择性阻断癌细胞周期的S期，从而扰乱周期并逐步诱导凋亡，从而产生抗癌作用。 因此，本发明的daurinol可以用作癌症生物学研究和开发领域的阳性对照化学品，特别是用于癌症治疗和预防。 Daurinol也可能是新型细胞周期阻滞剂和新型细胞凋亡诱导因子的有希望的候选者，可以有效地用于预防和治疗癌症。

    PHARMACEUTICAL COMPOSITION CONTAINING DAURINOL FOR THE PREVENTION AND TREATMENT OF CANCERS
    6.
    发明申请
    PHARMACEUTICAL COMPOSITION CONTAINING DAURINOL FOR THE PREVENTION AND TREATMENT OF CANCERS 有权
    含有DAURINOL的药物组合物用于预防和治疗癌症

    公开(公告)号：US20100105769A1

    公开(公告)日：2010-04-29

    申请号：US12529828

    申请日：2007-10-10

    Applicant: Chu Won Nho ,  Kyung Su Kang ,  Saet Byoul Lee ,  Batsuren Dulamjav ,  Tunsag Jigjidsuren

    Inventor： Chu Won Nho ,  Kyung Su Kang ,  Saet Byoul Lee ,  Batsuren Dulamjav ,  Tunsag Jigjidsuren

    IPC: A61K31/365 ,  A61P35/00 ,  C12N5/00

    CPC classification number: A61K36/75 ,  A61K31/343

    Abstract: The present invention relates to a pharmaceutical composition for the prevention and treatment of cancer comprising daurinol as an active ingredient, more precisely a pharmaceutical composition for the prevention and treatment of cancer comprising daurinol isolated from the medicinal plant of Mongolia, Haplophyllum dauricum or Haplophyllum cappadocicum, as an active ingredient. Daurinol can selectively block the S phase of cancer cell cycle to disturb the cycle and induce apoptosis stepwise, resulting in anticancer effect. Therefore, daurinol of the present invention can be used as a positive control chemical in the research and development field of cancer biology especially for cancer therapy and prevention. Daurinol also can be a promising candidate for a novel cell cycle blocker and a novel apoptosis inducer which could be effectively used for the prevention and treatment of cancer in the end.

    Abstract translation: 本发明涉及一种用于预防和治疗癌症的药物组合物，其包含戴尼醇作为活性成分，更确切地说，涉及一种用于预防和治疗癌症的药物组合物，其包含从蒙古药用植物，Haplophyllum dauricum或Haplophyllum cappadocicum分离的多萝醇， 作为活性成分。 Daurinol可以选择性阻断癌细胞周期的S期，从而扰乱周期并逐步诱导凋亡，从而产生抗癌作用。 因此，本发明的daurinol可以用作癌症生物学研究和开发领域的阳性对照化学品，特别是用于癌症治疗和预防。 Daurinol也可能是新型细胞周期阻滞剂和新型细胞凋亡诱导因子的有希望的候选者，可以有效地用于预防和治疗癌症。

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