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公开(公告)号：US08877194B2
公开(公告)日：2014-11-04
申请号：US13314878
申请日：2011-12-08
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/241 , A61K39/3955 , A61K45/06 , A61K47/48546 , A61K47/6845 , A61K49/0058 , A61K51/1021 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/14 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6863
摘要： TNF-α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind TNF-α are provided. Binding proteins have high affinity for TNF-α and neutralize TNF-α activity. A binding protein can be a full-length antibody or a TNF-α-binding portion thereof. Methods of making and methods of using the binding proteins are also described. The TNF-α binding proteins are useful for detecting TNF-α and for inhibiting TNF-α activity, including in a human subject suffering from a disease or disorder in which TNF-α activity is detrimental.
摘要翻译： 提供TNF-α结合蛋白，包括结合TNF-α的嵌合，CDR移植和人源化抗体。 结合蛋白对TNF-α具有高亲和力，并中和TNF-α活性。 结合蛋白可以是全长抗体或其TNF-α结合部分。 还描述了制备方法和使用结合蛋白的方法。 TNF-α结合蛋白可用于检测TNF-α和抑制TNF-α活性，包括在患有TNF-α活性有害的疾病或病症的人类受试者中。
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公开(公告)号：US08999331B2
公开(公告)日：2015-04-07
申请号：US13659647
申请日：2012-10-24
申请人： Chung-Ming Hsieh , Alexander Ivanov , Wendy Waegell , Yuliya Kutskova , John Memmott , Lorenzo Benatuil , Jacqueline Bixby , Emma Fung , Sahana Bose , Alyssa Brito
发明人： Chung-Ming Hsieh , Alexander Ivanov , Wendy Waegell , Yuliya Kutskova , John Memmott , Lorenzo Benatuil , Jacqueline Bixby , Emma Fung , Sahana Bose , Alyssa Brito
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/24 , A61K31/353 , A61K31/439 , A61K31/44 , A61K31/4439 , A61K31/519 , A61K31/56 , A61K38/13 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/21
CPC分类号： C07K16/468 , A61K31/353 , A61K31/439 , A61K31/44 , A61K31/4439 , A61K31/519 , A61K31/56 , A61K38/13 , A61K38/1793 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/19 , A61K38/191 , A61K38/2026 , A61K38/2066 , A61K38/2073 , A61K38/217 , A61K39/3955 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K16/241 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/60 , C07K2317/64 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： Proteins that bind sclerostin or sclerostin and TNF are described along with there use in composition and methods for treating, preventing, and diagnosing sclerostin related diseases and for detecting sclerostin or sclerostin and TNF in cells, tissues, samples, and compositions.
摘要翻译： 与用于治疗，预防和诊断硬化性相关疾病的组合物和方法一起描述了结合硬化蛋白或硬化性骨肉瘤和TNF的蛋白质，并用于检测细胞，组织，样品和组合物中的硬化蛋白或硬化性骨肉瘤和TNF。
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公开(公告)号：US20120230911A1
公开(公告)日：2012-09-13
申请号：US13314878
申请日：2011-12-08
IPC分类号： A61K51/10 , C12P21/00 , C12N9/96 , C12N5/10 , C12N1/15 , C12N1/11 , C12N15/63 , G01N33/566 , C07K16/24 , C07H21/04 , A61P21/02 , A61P29/00 , A61P25/20 , A61P31/00 , A61P37/02 , A61P37/06 , A61P5/00 , A61P25/24 , A61P25/18 , A61P11/06 , A61P1/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P3/10 , A61P37/08 , A61P11/00 , A61P17/00 , A61P1/16 , A61P35/00 , A61P31/12 , A61P31/04 , A61P33/00 , A61K39/395
CPC分类号： C07K16/241 , A61K39/3955 , A61K45/06 , A61K47/48546 , A61K47/6845 , A61K49/0058 , A61K51/1021 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/14 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6863
摘要： TNF-α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind TNF-α are provided. Binding proteins have high affinity for TNF-α and neutralize TNF-α activity. A binding protein can be a full-length antibody or a TNF-α-binding portion thereof. Methods of making and methods of using the binding proteins are also described. The TNF-α binding proteins are useful for detecting TNF-α and for inhibiting TNF-α activity, including in a human subject suffering from a disease or disorder in which TNF-α activity is detrimental.
摘要翻译： 提供TNF-α结合蛋白，包括结合TNF-α的嵌合，CDR移植和人源化抗体。 结合蛋白对TNF-α具有高亲和力，并中和TNF-α活性。 结合蛋白可以是全长抗体或其TNF-α结合部分。 还描述了制备方法和使用结合蛋白的方法。 TNF-α结合蛋白可用于检测TNF-α和抑制TNF-α活性，包括在患有TNF-α活性有害的疾病或病症的人类受试者中。
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